PMID- 35212052
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220407
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 33
IP  - 2
DP  - 2022 Feb
TI  - Cytokine profiles in cord blood in relation to prenatal traffic-related air 
      pollution: The NELA cohort.
PG  - e13732
LID - 10.1111/pai.13732 [doi]
AB  - BACKGROUND: Outdoor air pollution may disturb immune system development. We 
      investigated whether gestational exposure to traffic-related air pollutants 
      (TRAP) is associated with unstimulated cytokine profiles in newborns. METHODS: 
      Data come from 235 newborns of the NELA cohort. Innate response-related cytokines 
      (IL-6, IFN-alpha, IL1-beta, and TNF-alpha), Th1-related (IFN-gamma and IL-2), Th2-related (IL-4, 
      IL-5, and IL-13), Th17-related (IL-17 and IL-23), and immunomodulatory cytokine 
      IL-10 were quantified in the supernatant of unstimulated whole umbilical cord 
      blood cells after 7 days of culture using the Luminex technology. 
      Dispersion/chemical transport modeling was used to estimate long-term (whole 
      pregnancy and trimesters) and short-term (15 days before delivery) residential 
      exposures to traffic-related nitrogen dioxide (NO(2) ), particulate matter 
      (PM(2.5) and PM(10) ), and ozone (O(3) ). We fitted multivariable logistic 
      regression, Bayesian kernel machine regression (BKMR), and weighted quantile sum 
      (WQS) regression models. RESULTS: NO(2) during the whole pregnancy increased the 
      odds of detection of IL-1beta (OR per 10 microg/m(3) increase = 1.37; 95% CI, 1.02, 
      1.85) and IL-6 (OR per 10 microg/m(3) increase = 1.32; 95% CI 1.00, 1.75). Increased 
      odds of detected concentrations of IL-10 was found in newborns exposed during 
      whole pregnancy to higher levels of NO(2) (OR per 10 microg/m(3) increase = 1.30; 95% 
      CI 0.99, 1.69), PM(10) (OR per 10 microg/m(3) increase = 1.49; 95% CI 0.95, 2.33), 
      and PM(2.5) (OR per 5 microg/m(3) increase = 1.56; 95% CI 0.97, 2.51). Exposure to 
      O(3) during the whole pregnancy increased the odds of detected IL-13 (OR per 
      10 microg/m(3) increase = 1.22; 95% CI 1.01, 1.49). WQS model revealed first and 
      third trimesters of gestation as windows of higher susceptibility. CONCLUSIONS: 
      Gestational exposure to TRAP may increase detection of pro-inflammatory, 
      Th2-related, and T regulatory cytokines in newborns. These changes might 
      influence immune system responses later in life.
CI  - (c) 2022 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
FAU - Garcia-Serna, Azahara M
AU  - Garcia-Serna AM
AUID- ORCID: 0000-0001-7828-3213
AD  - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
AD  - Department of Biochemistry and Molecular Biology B and Immunology, Faculty of 
      Medicine, University of Murcia, Murcia, Spain.
FAU - Martin-Orozco, Elena
AU  - Martin-Orozco E
AUID- ORCID: 0000-0002-6303-481X
AD  - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
AD  - Department of Biochemistry and Molecular Biology B and Immunology, Faculty of 
      Medicine, University of Murcia, Murcia, Spain.
AD  - Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Madrid, Spain.
FAU - Jimenez-Guerrero, Pedro
AU  - Jimenez-Guerrero P
AUID- ORCID: 0000-0002-3156-0671
AD  - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
AD  - Regional Atmospheric Modelling Group, Department of Physics, University of 
      Murcia, Murcia, Spain.
FAU - Hernandez-Caselles, Trinidad
AU  - Hernandez-Caselles T
AUID- ORCID: 0000-0001-6727-8320
AD  - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
AD  - Department of Biochemistry and Molecular Biology B and Immunology, Faculty of 
      Medicine, University of Murcia, Murcia, Spain.
AD  - Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Madrid, Spain.
FAU - Perez-Fernandez, Virginia
AU  - Perez-Fernandez V
AD  - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
AD  - Department of Public Health Sciences, Faculty of Medicine, University of Murcia, 
      Murcia, Spain.
FAU - Cantero-Cano, Esther
AU  - Cantero-Cano E
AD  - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
FAU - Munoz-Garcia, Maria
AU  - Munoz-Garcia M
AD  - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
FAU - Molina-Ruano, Maria Dolores
AU  - Molina-Ruano MD
AD  - Obstetrics & Gynecology Service, Virgen de la Arrixaca University Clinical 
      Hospital, University of Murcia, Murcia, Spain.
FAU - Rojo-Atenza, Encarna
AU  - Rojo-Atenza E
AD  - Obstetrics & Gynecology Service, Virgen de la Arrixaca University Clinical 
      Hospital, University of Murcia, Murcia, Spain.
FAU - Garcia-Marcos, Luis
AU  - Garcia-Marcos L
AD  - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
AD  - Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Madrid, Spain.
AD  - Pediatric Allergy and Pulmonology Units, Virgen de la Arrixaca University 
      Children's Hospital, University of Murcia, Murcia, Spain.
FAU - Morales, Eva
AU  - Morales E
AUID- ORCID: 0000-0003-3145-7022
AD  - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
AD  - Department of Public Health Sciences, Faculty of Medicine, University of Murcia, 
      Murcia, Spain.
CN  - NELA Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Air Pollutants)
RN  - 0 (Cytokines)
RN  - 0 (Particulate Matter)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - *Air Pollutants/adverse effects/analysis
MH  - *Air Pollution/adverse effects
MH  - Bayes Theorem
MH  - Cytokines
MH  - Environmental Exposure/adverse effects
MH  - Female
MH  - Fetal Blood
MH  - Humans
MH  - Infant, Newborn
MH  - Nitrogen Dioxide/adverse effects/analysis
MH  - Particulate Matter/adverse effects
MH  - Pregnancy
OTO - NOTNLM
OT  - air pollution
OT  - birth cohort
OT  - cord blood
OT  - cytokines
OT  - traffic
FIR - Candel-Torralba, M E
IR  - Candel-Torralba ME
FIR - Garcia-Marcos, L
IR  - Garcia-Marcos L
FIR - Gimenez-Banon, M J
IR  - Gimenez-Banon MJ
FIR - Martinez-Torres, A
IR  - Martinez-Torres A
FIR - Morales, E
IR  - Morales E
FIR - Perez-Fernandez, V
IR  - Perez-Fernandez V
FIR - Sanchez-Solis, M
IR  - Sanchez-Solis M
FIR - Nieto, A
IR  - Nieto A
FIR - Prieto-Sanchez, M T
IR  - Prieto-Sanchez MT
FIR - Sanchez-Ferrer, M
IR  - Sanchez-Ferrer M
FIR - Fernanez-Palacios, L
IR  - Fernanez-Palacios L
FIR - Gomez-Gomez, V P
IR  - Gomez-Gomez VP
FIR - Martinez-Gracia, C
IR  - Martinez-Gracia C
FIR - Peso-Echarri, P
IR  - Peso-Echarri P
FIR - Ros-Berruezo, G
IR  - Ros-Berruezo G
FIR - Santaella-Pacual, M
IR  - Santaella-Pacual M
FIR - Gazquez, A
IR  - Gazquez A
FIR - Larque, E
IR  - Larque E
FIR - Pastor-Fajardo, M T
IR  - Pastor-Fajardo MT
FIR - Sanchez-Campillo, M
IR  - Sanchez-Campillo M
FIR - Serrano-Munuera, A
IR  - Serrano-Munuera A
FIR - Zornoza-Moreno, M
IR  - Zornoza-Moreno M
FIR - Jimenez-Guerrero, P
IR  - Jimenez-Guerrero P
FIR - Adomnei, E
IR  - Adomnei E
FIR - Arense-Gonzalo, J J
IR  - Arense-Gonzalo JJ
FIR - Mendiola, J
IR  - Mendiola J
FIR - Navarro-Lafuente, F
IR  - Navarro-Lafuente F
FIR - Torres-Cantero, A M
IR  - Torres-Cantero AM
FIR - Salvador-Garcia, C
IR  - Salvador-Garcia C
FIR - Segovia-Hernandez, M
IR  - Segovia-Hernandez M
FIR - Yague-Guirao, G
IR  - Yague-Guirao G
FIR - Valero-Guillen, P L
IR  - Valero-Guillen PL
FIR - Aviles-Plaza, F V
IR  - Aviles-Plaza FV
FIR - Cabezas-Herrera, J
IR  - Cabezas-Herrera J
FIR - Martinez-Lopez, A
IR  - Martinez-Lopez A
FIR - Martinez-Villanueva, M
IR  - Martinez-Villanueva M
FIR - Noguera-Velasco, J A
IR  - Noguera-Velasco JA
FIR - Franco-Garcia, A
IR  - Franco-Garcia A
FIR - Garcia-Serna, A M
IR  - Garcia-Serna AM
FIR - Hernandez-Caselles, T
IR  - Hernandez-Caselles T
FIR - Martin-Orozco, E
IR  - Martin-Orozco E
FIR - Norte-Munoz, M
IR  - Norte-Munoz M
FIR - Canovas, M
IR  - Canovas M
FIR - Cantero-Cano, E
IR  - Cantero-Cano E
FIR - de Diego, T
IR  - de Diego T
FIR - Pastor, J M
IR  - Pastor JM
FIR - Sola-Martinez, R A
IR  - Sola-Martinez RA
FIR - Esteban-Gil, A
IR  - Esteban-Gil A
FIR - Fernandez-Breis, J T
IR  - Fernandez-Breis JT
FIR - Alcantara, M V
IR  - Alcantara MV
FIR - Hernandez, S
IR  - Hernandez S
FIR - Lopez-Soler, C
IR  - Lopez-Soler C
EDAT- 2022/02/26 06:00
MHDA- 2022/04/08 06:00
CRDT- 2022/02/25 05:42
PHST- 2022/01/12 00:00 [revised]
PHST- 2021/10/04 00:00 [received]
PHST- 2022/01/13 00:00 [accepted]
PHST- 2022/02/25 05:42 [entrez]
PHST- 2022/02/26 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
AID - 10.1111/pai.13732 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2022 Feb;33(2):e13732. doi: 10.1111/pai.13732.