PMID- 35212852
OWN - NLM
STAT- MEDLINE
DCOM- 20230921
LR  - 20230921
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 38
IP  - 8
DP  - 2022 Aug
TI  - Left atrial remodeling in heart failure: the role of sphericity index (the 
      SPHERICAT-HF study).
PG  - 1723-1732
LID - 10.1007/s10554-022-02562-7 [doi]
AB  - Left atrial sphericity index (LASI) is an echocardiographic index easily 
      obtained; its use in patients with heart failure (HF) has never been investigated 
      so far. This single-centre study aimed to investigate the usefulness of LASI in 
      an unselected cohort of patients hospitalized for acute HF, and its potential 
      correlation with the amino-terminal portion of pro-B-type natriuretic peptide 
      (NT-proBNP) levels and with New York Heart Association (NYHA) functional class. 
      Ninety-four consecutive HF patients underwent a transthoracic echocardiogram with 
      a detailed study of the left atrium (LA) including LASI (calculated from the 
      apical four-chamber view as the ratio between the transverse and longitudinal 
      diameters), and blood tests (including NT-proBNP) on the same day. Median age was 
      75.5 (interquartile range-IQR 62-82) years and 55% were males, 58.5% had a NYHA 
      class III-IV, and median NT-proBNP was 3284 (IQR 1215-7055) pg/ml. The LA was 
      dilated in 94%, and median biplane LA volume index was 62 ml/m(2). Patients with 
      advanced NYHA class showed more advanced LA remodeling. Mean LASI was 0.78 +/- 0.09 
      and did not correlate with NT-proBNP levels (r 0.03; p 0.75) or with patient NYHA 
      class (R(2) 0.011; p 0.287). None of the echocardiographic indices of LA 
      structural and functional remodeling proved to be independently associated with a 
      high NYHA class on multivariate regression analysis. In conclusion, LA remodeling 
      is almost invariably present in patients with HF. LASI does not correlate with 
      NT-proBNP levels or with NYHA functional class. Further studies are needed to 
      describe the complex patterns of atrial remodeling in HF.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Sanna, Giuseppe D
AU  - Sanna GD
AUID- ORCID: 0000-0002-3357-0961
AD  - Clinical and Interventional Cardiology, Sassari University Hospital, Via Enrico 
      De Nicola, 07100, Sassari, Italy. giuseppe.sanna@aousassari.it.
FAU - Moccia, Eleonora
AU  - Moccia E
AD  - The Department of Medical, Surgical and Experimental Sciences, University of 
      Sassari, Sassari, Italy.
FAU - Canonico, Mario Enrico
AU  - Canonico ME
AD  - The Department of Medical, Surgical and Experimental Sciences, University of 
      Sassari, Sassari, Italy.
AD  - Department of Advanced Biomedical Sciences, Federico II University Hospital, 
      Naples, Italy.
FAU - Sanna, Silvia
AU  - Sanna S
AD  - The Department of Medical, Surgical and Experimental Sciences, University of 
      Sassari, Sassari, Italy.
FAU - De Toni, Chiara
AU  - De Toni C
AD  - The Department of Medical, Surgical and Experimental Sciences, University of 
      Sassari, Sassari, Italy.
FAU - Santoro, Ciro
AU  - Santoro C
AD  - Department of Advanced Biomedical Sciences, Federico II University Hospital, 
      Naples, Italy.
FAU - Masia, Stefano L
AU  - Masia SL
AD  - Clinical and Interventional Cardiology, Sassari University Hospital, Via Enrico 
      De Nicola, 07100, Sassari, Italy.
FAU - Saderi, Laura
AU  - Saderi L
AD  - Clinical Epidemiology and Medical Statistics Unit, Department of Medical, 
      Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
FAU - Sotgiu, Giovanni
AU  - Sotgiu G
AD  - Clinical Epidemiology and Medical Statistics Unit, Department of Medical, 
      Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
FAU - Parodi, Guido
AU  - Parodi G
AD  - The Department of Medical, Surgical and Experimental Sciences, University of 
      Sassari, Sassari, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220225
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 0 (Peptide Fragments)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Male
MH  - Humans
MH  - Aged
MH  - Female
MH  - *Atrial Remodeling
MH  - Predictive Value of Tests
MH  - *Heart Failure
MH  - Heart Atria/diagnostic imaging
MH  - Echocardiography
MH  - Natriuretic Peptide, Brain
MH  - Peptide Fragments
MH  - Biomarkers
OTO - NOTNLM
OT  - Heart failure
OT  - Left atrial sphericity index
OT  - NT-proBNP
OT  - NYHA functional class
EDAT- 2022/02/26 06:00
MHDA- 2023/09/21 06:42
CRDT- 2022/02/25 12:23
PHST- 2021/12/16 00:00 [received]
PHST- 2022/02/07 00:00 [accepted]
PHST- 2023/09/21 06:42 [medline]
PHST- 2022/02/26 06:00 [pubmed]
PHST- 2022/02/25 12:23 [entrez]
AID - 10.1007/s10554-022-02562-7 [pii]
AID - 10.1007/s10554-022-02562-7 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2022 Aug;38(8):1723-1732. doi: 
      10.1007/s10554-022-02562-7. Epub 2022 Feb 25.