PMID- 35212942
OWN - NLM
STAT- MEDLINE
DCOM- 20220510
LR  - 20220619
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 28
IP  - 1
DP  - 2022 Feb
TI  - MicroRNA expression profiling of cerebrospinal fluid/serum exosomes in children 
      with human herpesvirus 6-associated encephalitis/encephalopathy by 
      high-throughput sequencing.
PG  - 151-157
LID - 10.1007/s13365-022-01058-3 [doi]
AB  - Primary human herpesvirus 6 (HHV-6) infection is sometimes accompanied by acute 
      encephalopathy with reduced subcortical diffusion (AED) in immunocompetent 
      children. We investigated exosomal microRNA (miRNA) expression profiles in 
      cerebrospinal fluid (CSF) and sera of patients with HHV-6-associated AED (n = 5) 
      and febrile seizure (FS) (n = 5) using high-throughput sequencing. A total of 176 
      and 663 miRNAs were identified in CSF and serum exosomes, respectively. 
      Comparative analysis determined that some miRNAs (miR-381-3p, miR-155) were 
      exclusively expressed in the CSF exosomes of AED but not of FS patients, 
      suggesting their potential application as novel diagnostic biomarkers for AED.
CI  - (c) 2022. Journal of NeuroVirology, Inc.
FAU - Torii, Yuka
AU  - Torii Y
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Kawada, Jun-Ichi
AU  - Kawada JI
AUID- ORCID: 0000-0003-1553-2539
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. kawadaj@med.nagoya-u.ac.jp.
FAU - Horiba, Kazuhiro
AU  - Horiba K
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Okumura, Toshihiko
AU  - Okumura T
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Suzuki, Takako
AU  - Suzuki T
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
FAU - Ito, Yoshinori
AU  - Ito Y
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220225
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (MIRN381 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Child
MH  - *Encephalitis, Viral/genetics/metabolism
MH  - *Exosomes/genetics/metabolism
MH  - *Herpesvirus 6, Human/genetics
MH  - High-Throughput Nucleotide Sequencing
MH  - Humans
MH  - *MicroRNAs/genetics
MH  - *Roseolovirus Infections/genetics
OTO - NOTNLM
OT  - Acute encephalopathy with reduced subcortical diffusion
OT  - Encephalopathy
OT  - High-throughput sequencing
OT  - Human herpesvirus 6
OT  - MicroRNA
EDAT- 2022/02/26 06:00
MHDA- 2022/05/11 06:00
CRDT- 2022/02/25 12:24
PHST- 2020/11/17 00:00 [received]
PHST- 2022/02/01 00:00 [accepted]
PHST- 2021/05/13 00:00 [revised]
PHST- 2022/02/26 06:00 [pubmed]
PHST- 2022/05/11 06:00 [medline]
PHST- 2022/02/25 12:24 [entrez]
AID - 10.1007/s13365-022-01058-3 [pii]
AID - 10.1007/s13365-022-01058-3 [doi]
PST - ppublish
SO  - J Neurovirol. 2022 Feb;28(1):151-157. doi: 10.1007/s13365-022-01058-3. Epub 2022 
      Feb 25.