PMID- 35214065
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220301
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 14
IP  - 2
DP  - 2022 Jan 30
TI  - Deep Eutectic Solvents for Improving the Solubilization and Delivery of Dapsone.
LID - 10.3390/pharmaceutics14020333 [doi]
LID - 333
AB  - Owing to a growing awareness toward environmental impact, the use of safer and 
      eco-friendly solvents like deep eutectic solvents (DESs), has recently undergone 
      important growth in the pharmaceutical field, with regard to their application as 
      non-aqueous liquid administration vehicles, since they do not carry the same 
      risks of toxicity and handling as traditional organic solvents. Major attention 
      has been given to the development of advantageous transdermal drug delivery 
      systems, because of their ease of use and better acceptability. Here, we report 
      the use of two different DESs, based on choline chloride, used as hydrogen bond 
      acceptor (HBA), and ascorbic acid or propylene glycol, used as hydrogen bond 
      donors (HBDs), able to enhance the solubility and the topical delivery of 
      dapsone, representing a class IV drug. The interactions between the DESs' 
      components and the drug were studied by performing DSC, FT-IR, and NMR analysis 
      of the eutectic systems and the pure drug, confirming the establishment of 
      H-bonds between the drug and the DESs' components. Diffusion and permeability 
      studies, carried out in a Franz cell, showed an increase in permeability, 
      highlighting the great potential of DESs as dissolution and permeation enhancers 
      in the development of novel and more effective drug delivery systems in topical 
      administration.
FAU - Trombino, Sonia
AU  - Trombino S
AD  - Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 
      87036 Rende, Italy.
FAU - Siciliano, Carlo
AU  - Siciliano C
AUID- ORCID: 0000-0002-0584-219X
AD  - Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 
      87036 Rende, Italy.
FAU - Procopio, Debora
AU  - Procopio D
AUID- ORCID: 0000-0001-8071-0288
AD  - Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 
      87036 Rende, Italy.
FAU - Curcio, Federica
AU  - Curcio F
AD  - Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 
      87036 Rende, Italy.
FAU - Lagana, Annarita S
AU  - Lagana AS
AD  - Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 
      87036 Rende, Italy.
FAU - Di Gioia, Maria Luisa
AU  - Di Gioia ML
AUID- ORCID: 0000-0001-5469-5459
AD  - Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 
      87036 Rende, Italy.
FAU - Cassano, Roberta
AU  - Cassano R
AUID- ORCID: 0000-0001-6980-6799
AD  - Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 
      87036 Rende, Italy.
LA  - eng
GR  - PON Health "Development and Industrial-ization of innovative drugs for 
      personalized molecular therapy" of Department of Phar-macy and Health and 
      Nutrition Sciences-Unical./This work was supported by Department of Pharmacy and 
      Health and Nutrition Sciences Department of Excellence L. 232/2016/
PT  - Journal Article
DEP - 20220130
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC8875782
OTO - NOTNLM
OT  - API
OT  - dapsone
OT  - deep eutectic solvents
OT  - drug delivery
OT  - drug solubility
OT  - green solvents
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/27 06:00
MHDA- 2022/02/27 06:01
PMCR- 2022/01/30
CRDT- 2022/02/26 01:02
PHST- 2021/12/27 00:00 [received]
PHST- 2022/01/26 00:00 [revised]
PHST- 2022/01/27 00:00 [accepted]
PHST- 2022/02/26 01:02 [entrez]
PHST- 2022/02/27 06:00 [pubmed]
PHST- 2022/02/27 06:01 [medline]
PHST- 2022/01/30 00:00 [pmc-release]
AID - pharmaceutics14020333 [pii]
AID - pharmaceutics-14-00333 [pii]
AID - 10.3390/pharmaceutics14020333 [doi]
PST - epublish
SO  - Pharmaceutics. 2022 Jan 30;14(2):333. doi: 10.3390/pharmaceutics14020333.