PMID- 35214138
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220301
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 14
IP  - 2
DP  - 2022 Feb 13
TI  - Physiologically Based Pharmacokinetic (PBPK) Model of Gold Nanoparticle-Based 
      Drug Delivery System for Stavudine Biodistribution.
LID - 10.3390/pharmaceutics14020406 [doi]
LID - 406
AB  - Computational modelling has gained attention for evaluating nanoparticle-based 
      drug delivery systems. Physiologically based pharmacokinetic (PBPK) modelling 
      provides a mechanistic approach for evaluating drug biodistribution. The aim of 
      this work is to develop a specific PBPK model to simulate stavudine 
      biodistribution after the administration of a 40 nm gold nanoparticle-based drug 
      delivery system in rats. The model parameters used have been obtained from 
      literature, in vitro and in vivo studies, and computer optimization. Based on 
      these, the PBPK model was built, and the compartments included were considered as 
      permeability rate-limited tissues. In comparison with stavudine solution, a 
      higher biodistribution of stavudine into HIV reservoirs and the modification of 
      pharmacokinetic parameters such as the mean residence time (MRT) have been 
      observed. These changes are particularly noteworthy in the liver, which presents 
      a higher partition coefficient (from 0.27 to 0.55) and higher MRT (from 1.28 to 
      5.67 h). Simulated stavudine concentrations successfully describe these changes 
      in the in vivo study results. The average fold error of predicted concentrations 
      after the administration of stavudine-gold nanoparticles was within the 
      0.5-2-fold error in all of the tissues. Thus, this PBPK model approach may help 
      with the pre-clinical extrapolation to other administration routes or the species 
      of stavudine gold nanoparticles.
FAU - Zazo, Hinojal
AU  - Zazo H
AUID- ORCID: 0000-0001-6753-4558
AD  - Area of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Avda Lcdo 
      Mendez Nieto, 37007 Salamanca, Spain.
AD  - Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
FAU - Colino, Clara I
AU  - Colino CI
AUID- ORCID: 0000-0003-3642-4203
AD  - Area of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Avda Lcdo 
      Mendez Nieto, 37007 Salamanca, Spain.
AD  - Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
FAU - Gutierrez-Millan, Carmen
AU  - Gutierrez-Millan C
AUID- ORCID: 0000-0003-0760-8636
AD  - Area of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Avda Lcdo 
      Mendez Nieto, 37007 Salamanca, Spain.
AD  - Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
FAU - Cordero, Andres A
AU  - Cordero AA
AD  - Area of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Avda Lcdo 
      Mendez Nieto, 37007 Salamanca, Spain.
FAU - Bartneck, Matthias
AU  - Bartneck M
AUID- ORCID: 0000-0003-1516-9610
AD  - Department of Medicine III, Medical Faculty, RWTH Aachen, Pauwelsstr. 30, 52074 
      Aachen, Germany.
FAU - Lanao, Jose M
AU  - Lanao JM
AD  - Area of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Avda Lcdo 
      Mendez Nieto, 37007 Salamanca, Spain.
AD  - Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
LA  - eng
PT  - Journal Article
DEP - 20220213
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC8875329
OTO - NOTNLM
OT  - PBPK model
OT  - biodistribution
OT  - gold nanoparticles
OT  - pharmacokinetics
OT  - stavudine
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/27 06:00
MHDA- 2022/02/27 06:01
PMCR- 2022/02/13
CRDT- 2022/02/26 01:02
PHST- 2021/12/29 00:00 [received]
PHST- 2022/02/10 00:00 [revised]
PHST- 2022/02/11 00:00 [accepted]
PHST- 2022/02/26 01:02 [entrez]
PHST- 2022/02/27 06:00 [pubmed]
PHST- 2022/02/27 06:01 [medline]
PHST- 2022/02/13 00:00 [pmc-release]
AID - pharmaceutics14020406 [pii]
AID - pharmaceutics-14-00406 [pii]
AID - 10.3390/pharmaceutics14020406 [doi]
PST - epublish
SO  - Pharmaceutics. 2022 Feb 13;14(2):406. doi: 10.3390/pharmaceutics14020406.