PMID- 35214714
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220301
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 10
IP  - 2
DP  - 2022 Feb 8
TI  - A Systematic Review of T Cell Epitopes Defined from the Proteome of Hepatitis B 
      Virus.
LID - 10.3390/vaccines10020257 [doi]
LID - 257
AB  - Hepatitis B virus (HBV) infection remains a worldwide health problem and no 
      eradicative therapy is currently available. Host T cell immune responses have 
      crucial influences on the outcome of HBV infection, however the development of 
      therapeutic vaccines, T cell therapies and the clinical evaluation of 
      HBV-specific T cell responses are hampered markedly by the lack of validated T 
      cell epitopes. This review presented a map of T cell epitopes functionally 
      validated from HBV antigens during the past 33 years; the human leukocyte antigen 
      (HLA) supertypes to present these epitopes, and the methods to screen and 
      identify T cell epitopes. To the best of our knowledge, a total of 205 CD8(+) T 
      cell epitopes and 79 CD4(+) T cell epitopes have been defined from HBV antigens 
      by cellular functional experiments thus far, but most are restricted to several 
      common HLA supertypes, such as HLA-A0201, A2402, B0702, DR04, and DR12 molecules. 
      Therefore, the currently defined T cell epitope repertoire cannot cover the major 
      populations with HLA diversity in an indicated geographic region. More researches 
      are needed to dissect a more comprehensive map of T cell epitopes, which covers 
      overall HBV proteome and global patients.
FAU - Wu, Yandan
AU  - Wu Y
AUID- ORCID: 0000-0003-4514-6823
AD  - Department of Microbiology and Immunology, Medical School of Southeast 
      University, Nanjing 210009, China.
FAU - Ding, Yan
AU  - Ding Y
AD  - Department of Microbiology and Immunology, Medical School of Southeast 
      University, Nanjing 210009, China.
FAU - Shen, Chuanlai
AU  - Shen C
AUID- ORCID: 0000-0002-3748-3742
AD  - Department of Microbiology and Immunology, Medical School of Southeast 
      University, Nanjing 210009, China.
LA  - eng
GR  - BE2017714/Jiangsu Province Science and Technology Department/
PT  - Journal Article
PT  - Review
DEP - 20220208
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC8878595
OTO - NOTNLM
OT  - HLA restriction
OT  - T cell epitope
OT  - hepatitis B virus
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/27 06:00
MHDA- 2022/02/27 06:01
PMCR- 2022/02/08
CRDT- 2022/02/26 01:03
PHST- 2022/01/05 00:00 [received]
PHST- 2022/02/04 00:00 [revised]
PHST- 2022/02/05 00:00 [accepted]
PHST- 2022/02/26 01:03 [entrez]
PHST- 2022/02/27 06:00 [pubmed]
PHST- 2022/02/27 06:01 [medline]
PHST- 2022/02/08 00:00 [pmc-release]
AID - vaccines10020257 [pii]
AID - vaccines-10-00257 [pii]
AID - 10.3390/vaccines10020257 [doi]
PST - epublish
SO  - Vaccines (Basel). 2022 Feb 8;10(2):257. doi: 10.3390/vaccines10020257.