PMID- 35215463
OWN - NLM
STAT- MEDLINE
DCOM- 20220301
LR  - 20220301
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 4
DP  - 2022 Feb 15
TI  - Exercise for the Diabetic Gut-Potential Health Effects and Underlying Mechanisms.
LID - 10.3390/nu14040813 [doi]
LID - 813
AB  - It can be assumed that changes in the gut microbiota play a crucial role in the 
      development of type 2 diabetes mellitus (T2DM). It is generally accepted that 
      regular physical activity is beneficial for the prevention and therapy of T2DM. 
      Therefore, this review analyzes the effects of exercise training on the gut 
      microbiota composition and the intestinal barrier function in T2DM. The current 
      literature shows that regular exercise can influence the gut microbiota 
      composition and the intestinal barrier function with ameliorative effects on 
      T2DM. In particular, increases in the number of short-chain fatty acid 
      (SCFA)-producing bacteria and improvements in the gut barrier integrity with 
      reduced endotoxemia seem to be key points for positive interactions between gut 
      health and T2DM, resulting in improvements in low-grade systemic inflammation 
      status and glycemic control. However, not all aspects are known in detail and 
      further studies are needed to further examine the efficacy of different training 
      programs, the role of myokines, SCFA-producing bacteria, and SCFAs in the 
      relevant metabolic pathways. As microbial signatures differ in individuals who 
      respond differently to exercise training programs, one scientific focus could be 
      the development of computer-based methods for the personalized analysis of the 
      gut microbiota in the context of a microbiota/microbiome-based training program.
FAU - Valder, Sarah
AU  - Valder S
AD  - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular 
      Research and Sport Medicine, German Sport University Cologne, 50933 Cologne, 
      Germany.
FAU - Brinkmann, Christian
AU  - Brinkmann C
AUID- ORCID: 0000-0001-8419-7565
AD  - Department of Preventive and Rehabilitative Sport Medicine, Institute of 
      Cardiovascular Research and Sport Medicine, German Sport University Cologne, 
      50933 Cologne, Germany.
AD  - Department of Fitness & Health, IST University of Applied Sciences, 40233 
      Dusseldorf, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220215
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Fatty Acids, Volatile)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/microbiology/therapy
MH  - Exercise
MH  - Fatty Acids, Volatile
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - *Microbiota
PMC - PMC8877907
OTO - NOTNLM
OT  - exercise
OT  - gut barrier function
OT  - gut microbiota
OT  - short-chain fatty acid
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/27 06:00
MHDA- 2022/03/03 06:00
PMCR- 2022/02/15
CRDT- 2022/02/26 01:05
PHST- 2022/01/14 00:00 [received]
PHST- 2022/02/10 00:00 [revised]
PHST- 2022/02/12 00:00 [accepted]
PHST- 2022/02/26 01:05 [entrez]
PHST- 2022/02/27 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2022/02/15 00:00 [pmc-release]
AID - nu14040813 [pii]
AID - nutrients-14-00813 [pii]
AID - 10.3390/nu14040813 [doi]
PST - epublish
SO  - Nutrients. 2022 Feb 15;14(4):813. doi: 10.3390/nu14040813.