PMID- 35216958 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230823 IS - 2531-1387 (Electronic) IS - 2531-1379 (Print) IS - 2531-1379 (Linking) VI - 45 Suppl 2 IP - Suppl 2 DP - 2023 Jul TI - Iron profile of pregnant sickle cell anemia patients in Odisha, India. PG - S11-S17 LID - S2531-1379(21)00123-1 [pii] LID - 10.1016/j.htct.2021.06.012 [doi] AB - INTRODUCTION: During pregnancy, the iron requirement increases to meet the optimal growth of the fetus and prevent iron deficiency anemia-related complications in the mother. However, in sickle cell disease (SCD) primarily due to repeated blood transfusions and hemolysis-induced recycling of iron, its supplementation during pregnancy remains questionable and may be harmful. METHODS: Twenty-five pregnant women with homozygous SCD and 25 pregnant women with normal hemoglobin variants were included as cases and control, respectively. Pregnancy and sickle cell anemia (SCA) were diagnosed using standard protocols. The serum iron, serum ferritin, total iron-binding capacity (TIBC), percentage transferrin saturation and C-reactive protein were estimated, as per the manufacturer's protocol. The complete blood count was performed. The unpaired 't-test' was performed using the SPSS v23.0 and the principal component analysis (PCA) was performed using the online software MetaboAnalyst for statistical analysis. MAIN RESULTS: The studied cases had significantly lower mean hemoglobin and higher mean corpuscular volume (MCV), compared to controls. The mean serum-iron, serum-ferritin and percentage transferrin-saturation in the cases were significantly higher than that of the controls, while the TIBC was lower in the cases (p < 0.0001). The mean level of serum iron, ferritin, percentage transferrin saturation and TIBC were 309.44 +/- 122.40mcg/dl, 860.36 +/- 624.64ng/ml, 42.6 +/- 17.30% and 241.32 +/- 96.30 mcg/dl, respectively, in the cases and 95.36 +/- 41.90mcg/dl, 122.28 +/- 49.70ng/ml, 15.83 +/- 3.10% and 492.6 +/- 149.40mcg/dl in the controls, respectively. Higher MCV, mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) with lower hemoglobin (Hb) were noted in the cases. The PCA revealed that the cases were more heterogeneous in terms of the variability of the iron status and hematological indices than the controls. CONCLUSION: The current study shows iron sufficiency in most cases of pregnancy with SCA and suggests that evaluation of iron status must be made before initiating iron prophylaxis in pregnant women with SCA, especially in regions having a high prevalence of sickle cell hemoglobinopathy. CI - Copyright (c) 2021 Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Sukla, Sunil Kumar AU - Sukla SK AD - Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla, Sambalpur, Odisha, India. FAU - Mohanty, Pradeep Kumar AU - Mohanty PK AD - Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla, Sambalpur, Odisha, India; Odisha Sickle Cell Project (NHM), Sickle Cell Institute, VIMSAR, Burla, Sambalpur, Odisha, India. FAU - Patel, Siris AU - Patel S AD - Odisha Sickle Cell Project (NHM), Sickle Cell Institute, VIMSAR, Burla, Sambalpur, Odisha, India. FAU - Das, Kishalaya AU - Das K AD - Odisha Sickle Cell Project (NHM), Sickle Cell Institute, VIMSAR, Burla, Sambalpur, Odisha, India. FAU - Hiregoudar, Mrutyunjay AU - Hiregoudar M AD - Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla, Sambalpur, Odisha, India. FAU - Soren, Uttam Kumar AU - Soren UK AD - Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla, Sambalpur, Odisha, India. FAU - Meher, Satyabrata AU - Meher S AD - Odisha Sickle Cell Project (NHM), Sickle Cell Institute, VIMSAR, Burla, Sambalpur, Odisha, India. Electronic address: satya.meher@gmail.com. LA - eng PT - Journal Article DEP - 20210911 PL - Brazil TA - Hematol Transfus Cell Ther JT - Hematology, transfusion and cell therapy JID - 101725732 PMC - PMC10433298 OTO - NOTNLM OT - Hematological Indices OT - Iron Overload OT - Iron Profile OT - Pregnancy OT - Sickle Cell Disease COIS- Conflicts of interest The authors have no conflicts of interest. EDAT- 2022/02/27 06:00 MHDA- 2022/02/27 06:01 PMCR- 2021/09/11 CRDT- 2022/02/26 05:33 PHST- 2020/12/03 00:00 [received] PHST- 2021/04/09 00:00 [revised] PHST- 2021/06/24 00:00 [accepted] PHST- 2022/02/27 06:01 [medline] PHST- 2022/02/27 06:00 [pubmed] PHST- 2022/02/26 05:33 [entrez] PHST- 2021/09/11 00:00 [pmc-release] AID - S2531-1379(21)00123-1 [pii] AID - 10.1016/j.htct.2021.06.012 [doi] PST - ppublish SO - Hematol Transfus Cell Ther. 2023 Jul;45 Suppl 2(Suppl 2):S11-S17. doi: 10.1016/j.htct.2021.06.012. Epub 2021 Sep 11.