PMID- 35217036 OWN - NLM STAT- MEDLINE DCOM- 20220504 LR - 20220504 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 826 DP - 2022 Jun 20 TI - Effects of co-exposure to multiple metals on children's behavior problems in China. PG - 154062 LID - S0048-9697(22)01154-8 [pii] LID - 10.1016/j.scitotenv.2022.154062 [doi] AB - Exposure to single metals have been linked to childhood behavior problems, But little is known about the effects of metals mixtures on children. We aimed to evaluate associations of multiple metals exposures in urine with childhood behavior in China. For this population-based study, the children eligible for inclusion provided urine samples and their parents agreed to take in-person interview. A total of 831 children were remained from three cities for the final analysis. Urinary metals concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS). The childhood behavior scores was calculated by the Conners' Parent Rating Scale (CPRS). Variable selection was achieved by the least absolute shrinkage and selection operator (LASSO) regularization and stepwise regression to for all metals in the study. Linear regression models and Bayesian kernel machine regression (BKMR) were applied to estimate the associations of urinary metals concentrations with children's behavior. In BKMR models, the overall effect of mixture was significantly associated with conduct problems, learning problems and hyperactive index when urinary metals concentrations were all above the 50th percentile compared to all of them at their medians. The models also suggested marginally significant interaction effects of Se and Fe as well as Se and Sb (P(Se)( *)(Fe) = 0.063; P(Se)( *)(Sb) = 0.061), with a decline in estimate of Se on learning problems when Sb/Fe levels were relatively high. The concentrations of 22 metals in boys were higher than girls. In summary, multiple metals are associated with an increased risk of childhood behavioral problems in China. Potential interaction effects of Se and Fe as well as Se and Sb on childhood behavior should be taken into consideration. CI - Copyright (c) 2022. Published by Elsevier B.V. FAU - Zhang, Chengcheng AU - Zhang C AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Jing, Danrong AU - Jing D AD - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. FAU - Huang, Xiaoyan AU - Huang X AD - Department of Pathology, Xiangya Hospital, Central South University, Changsha, China; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. FAU - Xiao, Yi AU - Xiao Y AD - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. Electronic address: xiaoyixy@csu.edu.cn. FAU - Shu, Zhihao AU - Shu Z AD - Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China. FAU - Luo, Dan AU - Luo D AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Duan, Yanying AU - Duan Y AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, China. FAU - He, Meian AU - He M AD - Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Xiao, Shuiyuan AU - Xiao S AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Chen, Xiang AU - Chen X AD - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. Electronic address: chenxiangck@csu.edu.cn. FAU - Huang, Zhijun AU - Huang Z AD - Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China. Electronic address: huangzj@csu.edu.cn. FAU - Shen, Minxue AU - Shen M AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. Electronic address: shenmx1988@csu.edu.cn. LA - eng PT - Journal Article DEP - 20220222 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Metals) SB - IM MH - Bayes Theorem MH - Child MH - China/epidemiology MH - Female MH - Humans MH - Linear Models MH - Male MH - Metals MH - *Problem Behavior OTO - NOTNLM OT - Bayesian kernel machine regression OT - Behavior OT - Children OT - Heavy metals COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/02/27 06:00 MHDA- 2022/05/06 06:00 CRDT- 2022/02/26 05:33 PHST- 2021/11/12 00:00 [received] PHST- 2022/02/17 00:00 [revised] PHST- 2022/02/17 00:00 [accepted] PHST- 2022/02/27 06:00 [pubmed] PHST- 2022/05/06 06:00 [medline] PHST- 2022/02/26 05:33 [entrez] AID - S0048-9697(22)01154-8 [pii] AID - 10.1016/j.scitotenv.2022.154062 [doi] PST - ppublish SO - Sci Total Environ. 2022 Jun 20;826:154062. doi: 10.1016/j.scitotenv.2022.154062. Epub 2022 Feb 22.