PMID- 35217143
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20220531
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 109
DP  - 2022 Apr
TI  - Association of exposure to prenatal per fl uoroalkyl substances and estrogen 
      receptor 1 polymorphisms with the second to fourth digit ratio in school-aged 
      children: The Hokkaido study.
PG  - 10-18
LID - S0890-6238(22)00022-3 [pii]
LID - 10.1016/j.reprotox.2022.02.002 [doi]
AB  - Per- and Polyfluoroalkyl substances (PFAS) have endocrine-disrupting effects. The 
      ratio of the lengths of the second and fourth digits (2D:4D) is a noninvasive 
      retrospective index of prenatal exposure to sex hormones, and estrogen receptor 1 
      (ESR1) polymorphisms may contribute to 2D:4D determination. We investigated 
      whether ESR1 polymorphisms modify the effects of prenatal PFAS exposure on 2D:4D. 
      Participants (n = 1024) with complete data in a prospective birth cohort study 
      (the Hokkaido Study) were included, and maternal plasma in the third trimester 
      was used to examine PFAS concentrations. 2D:4D was determined from photocopies of 
      palms of children using Vernier calipers. ESR1 polymorphisms (rs2234693, 
      rs9340799, and rs2077647) were genotyped by TaqMan polymerase chain reaction. 
      PFAS and 2D:4D association with ESR1 polymorphisms was assessed by multiple 
      linear regression adjusted for potential confounding factors. A 10-fold increase 
      in maternal perfluorooctanoic acid (PFOA) concentration was associated with a 
      1.54% [95% confidence interval (CI): 0.40, 2.68] increase in mean 2D:4D in 
      children with an AA genotype at rs9340799 and a 2.24% (95% CI: 0.57, 3.92) 
      increase in children with an AA genotype at rs2077647. A 10-fold increase in 
      perfluorododecanoic acid (PFDoDA) was associated with a significant increase in 
      2D:4D in children with the AA genotype [rs9340799, 1.18% (95% CI: 0.02, 2.34); 
      and rs2077647, 1.67% (95% CI: 0.05, 3.28)]. These associations were apparent 
      among males. A significant gene-environment interaction between PFOA or PFDoDA 
      and ESR1 polymorphism was detected. These findings suggest that ESR1 
      polymorphisms modify the effects of prenatal exposure to PFAS on sex 
      differentiation.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Nishimura, Yoko
AU  - Nishimura Y
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Hokk aido, 
      Japan; Center for Environmental and Health Sciences, Hokkaido University, 
      North-12, West-7, Kita-ku, Sapporo 060-0812, Japan; Department of Urology, 
      Sapporo Hokushin Hospital, Chuo-2-6, Atsubetsu-ku, Sapporo 004-8618, Japan.
FAU - Moriya, Kimihiko
AU  - Moriya K
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Hokk aido, 
      Japan; Department of Urology, Sapporo City General Hospital, North-11, West-13, 
      Chuo-ku, Sapporo 060-8604, Japan. Electronic address: k-moriya@med.hokudai.ac.jp.
FAU - Kobayashi, Sumitaka
AU  - Kobayashi S
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Ikeda-Araki, Atsuko
AU  - Ikeda-Araki A
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan; Faculty of Health Sciences, Hokkaido 
      University, North-12, West-5 Kita-ku, Sapporo 060-0812, Japan.
FAU - Sata, Fumihiro
AU  - Sata F
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan; Health Center, Chuo University, 42-8, 
      Ichigaya-Hommura-cho, Shinjuku-ku, Tokyo 162-8473, Japan.
FAU - Mitsui, Takahiko
AU  - Mitsui T
AD  - Department of Urology, Graduate School of Medical Science, University of 
      Yamanashi, Simokato-1110, Chuo 409-3898, Japan.
FAU - Itoh, Sachiko
AU  - Itoh S
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Miyashita, Chihiro
AU  - Miyashita C
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Cho, Kazutoshi
AU  - Cho K
AD  - Maternity and Perinatal Care Center, Hokkaido University Hospital, North-14, 
      West-5 Kita-ku, Sapporo 060-8648, Japan.
FAU - Kon, Masafumi
AU  - Kon M
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Hokk aido, 
      Japan.
FAU - Nakamura, Michiko
AU  - Nakamura M
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Hokk aido, 
      Japan.
FAU - Kitta, Takeya
AU  - Kitta T
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Hokk aido, 
      Japan.
FAU - Murai, Sachiyo
AU  - Murai S
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Hokk aido, 
      Japan.
FAU - Kishi, Reiko
AU  - Kishi R
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Shinohara, Nobuo
AU  - Shinohara N
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Hokk aido, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20220222
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Child
MH  - *Digit Ratios
MH  - *Estrogen Receptor alpha/genetics
MH  - Female
MH  - *Fluorocarbons/toxicity
MH  - Humans
MH  - Japan
MH  - Male
MH  - Pregnancy
MH  - Prospective Studies
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Birth cohort
OT  - ESR1 polymorphism
OT  - Gene environment interaction
OT  - Hand digit ratio
OT  - Per- and polyfluoroalkyl substances
EDAT- 2022/02/27 06:00
MHDA- 2022/04/06 06:00
CRDT- 2022/02/26 05:34
PHST- 2021/11/27 00:00 [received]
PHST- 2022/02/11 00:00 [revised]
PHST- 2022/02/19 00:00 [accepted]
PHST- 2022/02/27 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
PHST- 2022/02/26 05:34 [entrez]
AID - S0890-6238(22)00022-3 [pii]
AID - 10.1016/j.reprotox.2022.02.002 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2022 Apr;109:10-18. doi: 10.1016/j.reprotox.2022.02.002. Epub 
      2022 Feb 22.