PMID- 35217957
OWN - NLM
STAT- MEDLINE
DCOM- 20220708
LR  - 20220708
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 32
DP  - 2022 Jul
TI  - Gestational exposure to PCB-118 impairs placental angiogenesis and fetal growth.
PG  - 49126-49135
LID - 10.1007/s11356-022-19240-9 [doi]
AB  - Maternal exposure to polychlorinated biphenyls (PCBs) results in adverse effects 
      on fetal development. However, the underlying mechanism has not been sufficiently 
      explored in respect to particular PCBs. Placental angiogenesis plays a crucial 
      role in feto-maternal substances transportation and fetal development. The 
      present study was conducted to investigate the effects of prenatal PCB118 
      exposure on placental angiogenesis and fetal growth. The pregnant dam received 
      PCB118 at environmentally relevant doses (0, 20, or 100 mug/kg/day) 
      intragastrically from gestational day (GD) 7.5-18.5 to establish an in vivo 
      model. Compared with the control group, the fetal body and placental weights of 
      the PCB118 (100 mug/kg/day) group were significantly decreased and the 
      intrauterine growth retardation (IUGR) rates were increased both in the female 
      and male fetus. Furthermore, we found that placental histology was significantly 
      impaired and the number of blood vessels was decreased in the PCB118 group. 
      Additionally, gestational exposure to PCB118 caused anomalous mRNA expression of 
      the genes in the placenta regarding angiogenesis. These findings indicate that 
      PCB118 may contribute to the occurrence of IUGR by provoking placental 
      angiogenesis dysfunction. This study clarified the adverse effects and potential 
      mechanism of prenatal PCBs exposure on fetal growth, providing a new theoretical 
      and experimental basis for future treatment and prevention.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Ge, Caiyun
AU  - Ge C
AD  - Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, 
      430071, Hubei, People's Republic of China.
AD  - Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, 
      430071, Hubei, People's Republic of China.
AD  - Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, 
      Wuhan, 430071, Hubei, People's Republic of China.
FAU - Geng, Ting
AU  - Geng T
AD  - Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, 
      430071, Hubei, People's Republic of China.
AD  - Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, 
      430071, Hubei, People's Republic of China.
AD  - Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, 
      Wuhan, 430071, Hubei, People's Republic of China.
FAU - Cheng, Lin
AU  - Cheng L
AD  - Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, 
      430071, Hubei, People's Republic of China.
AD  - Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, 
      430071, Hubei, People's Republic of China.
AD  - Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, 
      Wuhan, 430071, Hubei, People's Republic of China.
FAU - Zhang, Yuanzhen
AU  - Zhang Y
AD  - Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, 
      430071, Hubei, People's Republic of China. zhangyuanzhen@whu.edu.cn.
AD  - Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, 
      430071, Hubei, People's Republic of China. zhangyuanzhen@whu.edu.cn.
AD  - Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, 
      Wuhan, 430071, Hubei, People's Republic of China. zhangyuanzhen@whu.edu.cn.
LA  - eng
GR  - 2020YFA0803900/National Key Research and Development Program of China/
GR  - 81771543/National Natural Science Foundation/
PT  - Journal Article
DEP - 20220225
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 2B2AQE8U50 (2,3',4,4',5-pentachlorobiphenyl)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Female
MH  - Fetal Development
MH  - Fetal Growth Retardation/chemically induced/metabolism/pathology
MH  - Humans
MH  - Male
MH  - *Placenta
MH  - *Polychlorinated Biphenyls/metabolism
MH  - Pregnancy
OTO - NOTNLM
OT  - 2,3',4,4',5-Pentachlorobiphenyl
OT  - Angiogenesis
OT  - Fetal growth restriction
OT  - PCB118
OT  - Placenta
OT  - Prenatal exposure
EDAT- 2022/02/27 06:00
MHDA- 2022/07/09 06:00
CRDT- 2022/02/26 05:45
PHST- 2021/10/25 00:00 [received]
PHST- 2022/02/11 00:00 [accepted]
PHST- 2022/02/27 06:00 [pubmed]
PHST- 2022/07/09 06:00 [medline]
PHST- 2022/02/26 05:45 [entrez]
AID - 10.1007/s11356-022-19240-9 [pii]
AID - 10.1007/s11356-022-19240-9 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Jul;29(32):49126-49135. doi: 
      10.1007/s11356-022-19240-9. Epub 2022 Feb 25.