PMID- 35218021
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20221208
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 132
IP  - 11
DP  - 2022 Nov
TI  - Association Between Alcohol Dehydrogenase Polymorphisms and the Recurrence of 
      Laryngeal Carcinoma.
PG  - 2169-2176
LID - 10.1002/lary.30083 [doi]
AB  - OBJECTIVES: Alcohol consumption is closely associated with prognosis for 
      laryngeal squamous cell carcinoma (LSCC) patients. As key enzymes in ethanol 
      metabolism, proteins in the alcohol dehydrogenase (ADH) family make for valuable 
      targets to establish a novel predictive nomogram model. This study attempts to do 
      so by focusing on the single nucleotide polymorphisms (SNPs) of ADH1B and ADH1C 
      in LSCC. METHODS: Sixty eight LSCC patients that were followed up for more than 
      10 years were retrospectively analyzed. Endpoints of the current study included 
      disease-free survival and overall survival. Survival analyses were performed 
      using the Kaplan-Meier method and evaluated by log-rank test. The prognostic 
      value of eight ADH1B SNPs and three ADH1C SNPs were evaluated using univariate 
      and multivariate Cox regression analyses. A nomogram model for disease-free 
      survival was established and evaluated using the receiver operating 
      characteristic curve, the C-index, and a calibration plot. RESULTS: Significant 
      association was exhibited between rs17033 (p < 0.001) and rs1229984 (p = 0.002) 
      with an increase in LSCC recurrence rate on Kaplan-Meier curves. Multivariate 
      logistic regression analysis revealed that the rs17033 polymorphism of ADH1B was 
      independently associated with an increased risk of LSCC recurrence (HR = 3.325, 
      95% CI = 1.684-6.566, p = 0.001). Based on these findings, a prognostic nomogram 
      of LSCC patients involving ADH1B rs17033 was constructed. CONCLUSION: This study 
      has demonstrated an independent association between ADH1B gene variants and the 
      recurrence of LSCC. A nomogram model based on rs17033 of ADH1B, age, T, and N 
      stages were successfully developed for the first time to predict the probability 
      of recurrence in LSCC patients. LEVEL OF EVIDENCE: 3 Retrospective cohort study 
      Laryngoscope, 132:2169-2176, 2022.
CI  - (c) 2022 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Huang, Hui-Ying
AU  - Huang HY
AUID- ORCID: 0000-0002-5587-3576
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 
      Shanghai, People's Republic of China.
FAU - Lau, Hui-Ching
AU  - Lau HC
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 
      Shanghai, People's Republic of China.
FAU - Ji, Meng-You
AU  - Ji MY
AUID- ORCID: 0000-0002-1006-1670
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 
      Shanghai, People's Republic of China.
FAU - Hsueh, Chi-Yao
AU  - Hsueh CY
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 
      Shanghai, People's Republic of China.
FAU - Zhang, Ming
AU  - Zhang M
AUID- ORCID: 0000-0003-2909-8446
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 
      Shanghai, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220225
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 3K9958V90M (Ethanol)
RN  - EC 1.1.1.1 (Alcohol Dehydrogenase)
SB  - IM
MH  - Alcohol Dehydrogenase/genetics
MH  - Ethanol
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Laryngeal Neoplasms/pathology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
OTO - NOTNLM
OT  - ADH1B
OT  - SNP
OT  - laryngeal carcinoma
OT  - nomogram
OT  - polymorphism
OT  - prognosis
EDAT- 2022/02/27 06:00
MHDA- 2022/10/19 06:00
CRDT- 2022/02/26 05:45
PHST- 2022/01/23 00:00 [revised]
PHST- 2021/10/19 00:00 [received]
PHST- 2022/02/14 00:00 [accepted]
PHST- 2022/02/27 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/02/26 05:45 [entrez]
AID - 10.1002/lary.30083 [doi]
PST - ppublish
SO  - Laryngoscope. 2022 Nov;132(11):2169-2176. doi: 10.1002/lary.30083. Epub 2022 Feb 
      25.