PMID- 35218208
OWN - NLM
STAT- MEDLINE
DCOM- 20220606
LR  - 20220731
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 63
IP  - 6
DP  - 2022 Jun
TI  - Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during 
      aging.
PG  - 1297-1313
LID - 10.1111/epi.17210 [doi]
AB  - The term neurovascular unit (NVU) describes the structural and functional liaison 
      between specialized brain endothelium, glial and mural cells, and neurons. Within 
      the NVU, the blood-brain barrier (BBB) is the microvascular structure regulating 
      neuronal physiology and immune cross-talk, and its properties adapt to brain 
      aging. Here, we analyze a research framework where NVU dysfunction, caused by 
      acute insults or disease progression in the aging brain, represents a converging 
      mechanism underlying late-onset seizures or epilepsy and neurological or 
      neurodegenerative sequelae. Furthermore, seizure activity may accelerate brain 
      aging by sustaining regional NVU dysfunction, and a cerebrovascular pathology may 
      link seizures to comorbidities. Next, we focus on NVU diagnostic approaches that 
      could be tailored to seizure conditions in the elderly. We also examine the 
      impending disease-modifying strategies based on the restoration of the NVU and, 
      more in general, the homeostatic control of anti- and pro-inflammatory players. 
      We conclude with an outlook on current pre-clinical knowledge gaps and clinical 
      challenges pertinent to seizure onset and conditions in an aging population.
CI  - (c) 2022 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of 
      International League Against Epilepsy.
FAU - van Vliet, Erwin A
AU  - van Vliet EA
AUID- ORCID: 0000-0001-5747-3202
AD  - Dept. of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, the 
      Netherlands.
AD  - Swammerdam Institute for Life Sciences, Center for Neuroscience, University of 
      Amsterdam, Amsterdam, the Netherlands.
FAU - Marchi, Nicola
AU  - Marchi N
AUID- ORCID: 0000-0001-9124-0226
AD  - Cerebrovascular and Glia Research, Department of Neuroscience, Institute of 
      Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, 
      France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220421
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
MH  - Aged
MH  - Aging
MH  - *Blood-Brain Barrier
MH  - Brain
MH  - *Epilepsy
MH  - Humans
MH  - Seizures
PMC - PMC9321014
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - aging
OT  - blood-brain barrier
OT  - cognitive decline
OT  - inflammation
OT  - late-onset epilepsy
OT  - neurodegeneration
OT  - seizures
OT  - stroke
OT  - traumatic brain injury
EDAT- 2022/02/27 06:00
MHDA- 2022/06/07 06:00
PMCR- 2022/07/26
CRDT- 2022/02/26 08:35
PHST- 2022/02/23 00:00 [revised]
PHST- 2022/01/05 00:00 [received]
PHST- 2022/02/23 00:00 [accepted]
PHST- 2022/02/27 06:00 [pubmed]
PHST- 2022/06/07 06:00 [medline]
PHST- 2022/02/26 08:35 [entrez]
PHST- 2022/07/26 00:00 [pmc-release]
AID - EPI17210 [pii]
AID - 10.1111/epi.17210 [doi]
PST - ppublish
SO  - Epilepsia. 2022 Jun;63(6):1297-1313. doi: 10.1111/epi.17210. Epub 2022 Apr 21.