PMID- 35218850
OWN - NLM
STAT- MEDLINE
DCOM- 20220504
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 186
DP  - 2022 Apr
TI  - Amino acid profile of skeletal muscle loss in type 2 diabetes: Results from a 
      7-year longitudinal study in asians.
PG  - 109803
LID - S0168-8227(22)00615-5 [pii]
LID - 10.1016/j.diabres.2022.109803 [doi]
AB  - AIMS: Little is known about pathophysiology of sarcopenia in diabetes. We aimed 
      to study amino acid profile associated with skeletal muscle mass loss 
      longitudinally in Type 2 Diabetes Mellitus (T2DM). METHODS: This is a prospective 
      study of 1140 patients aged 56.6 +/- 10.6 years from the SMART2D cohort. Skeletal 
      muscle mass was measured using bio-impedance analysis at baseline and follow-up. 
      Amino acids were measured by mass spectrometry. RESULTS: Over a period of up to 
      7.9 years, 43.9% experienced skeletal muscle mass loss. Lower baseline valine, 
      leucine and isoleucine levels were associated with decreased skeletal muscle mass 
      index (SMI) with corresponding coefficient 0.251(95 %CI 0.009 to 0.493), 
      0.298(95 %CI 0.051 to 0.544)) and 0.366(95 %CI 0.131 to 0.600). Higher baseline 
      valine, leucine, isoleucine, alanine and tryptophan levels were associated with 
      reduced odds of muscle mass loss with corresponding odds ratio (OR)0.797 (95 %CI 
      0.690 to 0.921), 0.825 (95 %CI 0.713 to 0.955), 0.826 (95 %CI 0.718-0.950), 0.847 
      (95 %CI 0.739-0.969) and 0.835 (95 %CI 0.720-0.979). CONCLUSION: The 
      branched-chain amino acids valine, leucine and isoleucine were positively 
      associated with change in SMI and reduced odds of muscle mass loss 
      longitudinally. Further studies should be conducted to elucidate the 
      pathophysiological mechanisms underlying the relationship between these amino 
      acids and muscle mass loss in T2DM.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Low, Serena
AU  - Low S
AD  - Diabetes Centre, Admiralty Medical Centre, Singapore; Clinical Research Unit, 
      Khoo Teck Puat Hospital, Singapore; Lee Kong Chian School of Medicine, Singapore.
FAU - Wang, Jiexun
AU  - Wang J
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
FAU - Moh, Angela
AU  - Moh A
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
FAU - Ang, Su Fen
AU  - Ang SF
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
FAU - Ang, Keven
AU  - Ang K
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
FAU - Shao, Yi-Ming
AU  - Shao YM
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
FAU - Ching, Jianhong
AU  - Ching J
AD  - Duke-NUS Medical School, Singapore; KK Research Centre, KK Women's and Children's 
      Hospital, Singapore.
FAU - Wee, Hai Ning
AU  - Wee HN
AD  - Duke-NUS Medical School, Singapore.
FAU - Lee, Lye Siang
AU  - Lee LS
AD  - Duke-NUS Medical School, Singapore.
FAU - Kovalik, Jean-Paul
AU  - Kovalik JP
AD  - Duke-NUS Medical School, Singapore.
FAU - Tang, Wern Ee
AU  - Tang WE
AD  - National Healthcare Group Polyclinics, Singapore.
FAU - Lim, Ziliang
AU  - Lim Z
AD  - National Healthcare Group Polyclinics, Singapore.
FAU - Subramaniam, Tavintharan
AU  - Subramaniam T
AD  - Diabetes Centre, Admiralty Medical Centre, Singapore.
FAU - Sum, Chee Fang
AU  - Sum CF
AD  - Diabetes Centre, Admiralty Medical Centre, Singapore.
FAU - Lim, Su Chi
AU  - Lim SC
AD  - Diabetes Centre, Admiralty Medical Centre, Singapore; Clinical Research Unit, 
      Khoo Teck Puat Hospital, Singapore; Lee Kong Chian School of Medicine, Singapore; 
      Saw Swee Hock School of Public Health, National University of Singapore, 
      Singapore. Electronic address: lim.su.chi@ktph.com.sg.
LA  - eng
PT  - Journal Article
DEP - 20220223
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Amino Acids)
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 04Y7590D77 (Isoleucine)
RN  - GMW67QNF9C (Leucine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Amino Acids
MH  - Amino Acids, Branched-Chain/metabolism
MH  - Asian People
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - Isoleucine
MH  - Leucine
MH  - Longitudinal Studies
MH  - Muscle, Skeletal
MH  - Prospective Studies
MH  - Valine
OTO - NOTNLM
OT  - Amino acid
OT  - Sarcopenia
OT  - Type 2 diabetes
EDAT- 2022/02/27 06:00
MHDA- 2022/05/06 06:00
CRDT- 2022/02/26 20:10
PHST- 2021/10/19 00:00 [received]
PHST- 2022/01/19 00:00 [revised]
PHST- 2022/02/19 00:00 [accepted]
PHST- 2022/02/27 06:00 [pubmed]
PHST- 2022/05/06 06:00 [medline]
PHST- 2022/02/26 20:10 [entrez]
AID - S0168-8227(22)00615-5 [pii]
AID - 10.1016/j.diabres.2022.109803 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2022 Apr;186:109803. doi: 10.1016/j.diabres.2022.109803. 
      Epub 2022 Feb 23.