PMID- 35218971
OWN - NLM
STAT- MEDLINE
DCOM- 20220414
LR  - 20220414
IS  - 1095-9947 (Electronic)
IS  - 1050-4648 (Linking)
VI  - 123
DP  - 2022 Apr
TI  - Dietary red macroalgae (Halopithys incurva) improved systemic an mucosal immune 
      and antioxidant parameters and modulated related gene expression in zebrafish 
      (Danio rerio).
PG  - 164-171
LID - S1050-4648(22)00109-7 [pii]
LID - 10.1016/j.fsi.2022.02.047 [doi]
AB  - In the present study, the effects of dietary Halopithys incurva, a red macroalgae 
      species, (0.25, 0.50, 1%) on whole-body serum and skin mucus immune system, 
      antioxidant system and expression of various genes in zebrafish were 
      investigated. At the end of the 8-week study, total protein, total immunoglobulin 
      and lysozyme activities in whole-body serum and skin mucus increased in fish fed 
      H. incurva (P < 0.05). While an increase was observed in superoxide dismutase 
      (SOD), Catalase (CAT) and glutathione peroxidase (GPx) which are antioxidant 
      enzyme activities in whole-body serum and skin mucus, a decrease in 
      malondialdehyde (MDA) levels was detected (P < 0.05). All of the immune-related 
      genes examined, such as Interleukin-1 beta (IL-1beta), Tumor necrosis factor-alpha 
      (TNF-alpha), Interferon-gamma (INF- gamma), were upregulated by the addition of 0.5% H. 
      incurva (P < 0.05). While SOD and GPx, which are antioxidant enzyme-related 
      genes, were remarkably upregulated in macroalgae fed fish (P < 0.05), no change 
      was observed in CAT gene expression (P > 0.05). Based on the results of this 
      study, it is considered that the addition of 0.5% H. incurva to the diets of 
      commercially farmed fish will increase their immune and antioxidant defences and 
      may contribute to the aquaculture sector for more sustainability.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Hoseinifar, Seyed Hossein
AU  - Hoseinifar SH
AD  - Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan 
      University of Agricultural Sciences and Natural Resources, Gorgan, Iran. 
      Electronic address: hoseinifar@gau.ac.ir.
FAU - Fazelan, Zohreh
AU  - Fazelan Z
AD  - Department of Animal Science and Aquaculture, Faculty of Agriculture, Dalhousie 
      University, Truro, Nova Scotia B2N 5E3, Canada.
FAU - Bayani, Mahsan
AU  - Bayani M
AD  - Radin Makian Azma Mehr Ltd, Radinmehr Veterinary Laboratory, Gorgan, Iran.
FAU - Yousefi, Morteza
AU  - Yousefi M
AD  - Department of Veterinary Medicine, Peoples' Friendship University of Russia (RUDN 
      University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation.
FAU - Van Doan, Hien
AU  - Van Doan H
AD  - Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai 
      University, Chiang Mai 50200, Thailand.
FAU - Yazici, Metin
AU  - Yazici M
AD  - Iskenderun Technical University, Faculty of Marine Sciences and Technology, 
      Iskenderun, Hatay, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220223
PL  - England
TA  - Fish Shellfish Immunol
JT  - Fish & shellfish immunology
JID - 9505220
RN  - 0 (Antioxidants)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animal Feed/analysis
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Diet/veterinary
MH  - Dietary Supplements
MH  - Gene Expression
MH  - *Rhodophyta
MH  - *Seaweed
MH  - Superoxide Dismutase/genetics
MH  - Zebrafish
OTO - NOTNLM
OT  - Antioxidant defence
OT  - Danio rerio
OT  - Humoral immunity
OT  - Mucosal immunity
OT  - Seaweeds
EDAT- 2022/02/27 06:00
MHDA- 2022/04/15 06:00
CRDT- 2022/02/26 20:11
PHST- 2021/12/13 00:00 [received]
PHST- 2022/02/16 00:00 [revised]
PHST- 2022/02/21 00:00 [accepted]
PHST- 2022/02/27 06:00 [pubmed]
PHST- 2022/04/15 06:00 [medline]
PHST- 2022/02/26 20:11 [entrez]
AID - S1050-4648(22)00109-7 [pii]
AID - 10.1016/j.fsi.2022.02.047 [doi]
PST - ppublish
SO  - Fish Shellfish Immunol. 2022 Apr;123:164-171. doi: 10.1016/j.fsi.2022.02.047. 
      Epub 2022 Feb 23.