PMID- 35219625
OWN - NLM
STAT- MEDLINE
DCOM- 20220509
LR  - 20220624
IS  - 2095-4964 (Print)
VI  - 20
IP  - 3
DP  - 2022 May
TI  - Functional connectivity changes during migraine treatment with electroacupuncture 
      at Shuaigu (GB8).
PG  - 237-243
LID - S2095-4964(22)00009-7 [pii]
LID - 10.1016/j.joim.2022.01.009 [doi]
AB  - OBJECTIVE: To investigate the changes in the functional connectivity (FC) in the 
      right insula between migraine without aura (MWoA) and healthy controls by using 
      resting-state functional magnetic resonance imaging (rs-fMRI), and to observe the 
      instant alteration of FC in MWoA during electroacupuncture (EA) stimulation at 
      Shuaigu (GB8). METHODS: A total of 30 patients with MWoA (PM group) and 30 
      healthy controls (HC group) underwent rs-fMRI scans. The PM group underwent a 
      second rs-fMRI scan while receiving EA at GB8. The right insula subregions, 
      including the ventral anterior insula (vAI), dorsal anterior insula (dAI) and 
      posterior insula (PI), were selected as the seed points for FC analysis. RESULTS: 
      Aberrant FC, including dAI with right postcentral gyrus, PI with left precuneus, 
      was found among PM before EA (PMa), PM during EA (PMb) and HC. Meanwhile, 
      decreased FC between dAI and the right postcentral gyrus was found in the PMa 
      compared to the HC and PMb. Increased FC between the PI and left precuneus was 
      found in the PMa compared to the HC and PMb. Correlation analysis showed that the 
      FC value of the right postcentral gyrus in PMa was negatively correlated with the 
      scores of Hamilton Rating Scale for Depression and Hamilton Rating Scale for 
      Anxiety. The FC value of the left precuneus in PMa was positively correlated with 
      the visual analogue scale score. CONCLUSION: The alteration of FC between the 
      right insula subregions and multiple brain regions may be an important index for 
      MWoA. EA at GB8 was able to adjust the FC between the right insula subregions and 
      parietal lobe, namely, the right dAI and right postcentral gyrus, and the right 
      PI and left precuneus, thereby rendering an instant effect in the management of 
      MWoA.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Wei, Xiang-Yu
AU  - Wei XY
AD  - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China.
FAU - Luo, Shi-Lei
AU  - Luo SL
AD  - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China.
FAU - Chen, Hui
AU  - Chen H
AD  - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China.
FAU - Liu, Shan-Shan
AU  - Liu SS
AD  - Department of Acupuncture & Moxibustion, Shuguang Hospital, Shanghai University 
      of Traditional Chinese Medicine, Shanghai 201203, China.
FAU - Gong, Zhi-Gang
AU  - Gong ZG
AD  - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China.
FAU - Zhan, Song-Hua
AU  - Zhan SH
AD  - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China. Electronic address: 
      zhansonghua@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220131
PL  - Netherlands
TA  - J Integr Med
JT  - Journal of integrative medicine
JID - 101603118
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Electroacupuncture
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - *Migraine without Aura
OTO - NOTNLM
OT  - Electroacupuncture
OT  - Functional magnetic resonance imaging
OT  - Functional status
OT  - Migraine
OT  - Shuaigu (GB8)
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/02/28 06:00
MHDA- 2022/05/10 06:00
CRDT- 2022/02/27 20:28
PHST- 2020/12/24 00:00 [received]
PHST- 2022/01/06 00:00 [accepted]
PHST- 2022/02/28 06:00 [pubmed]
PHST- 2022/05/10 06:00 [medline]
PHST- 2022/02/27 20:28 [entrez]
AID - S2095-4964(22)00009-7 [pii]
AID - 10.1016/j.joim.2022.01.009 [doi]
PST - ppublish
SO  - J Integr Med. 2022 May;20(3):237-243. doi: 10.1016/j.joim.2022.01.009. Epub 2022 
      Jan 31.