PMID- 35221600
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220301
IS  - 2005-3894 (Electronic)
IS  - 1013-9087 (Print)
IS  - 1013-9087 (Linking)
VI  - 34
IP  - 1
DP  - 2022 Feb
TI  - A Case of Primary Cutaneous Extraskeletal Ewing Sarcoma on the Abdomen.
PG  - 72-75
LID - 10.5021/ad.2022.34.1.72 [doi]
AB  - Primary cutaneous extraskeletal Ewing sarcoma (EWS) is a primitive 
      neuroectodermal tumor that usually occurs as a small, localized tumor on the 
      trunk or extremities of young adults. The prognosis is typically reported to be 
      quite favorable. It is extremely rare; only three cases of primary cutaneous EWS 
      have been reported in Korea. In the first report, molecular genetic testing was 
      not performed to make a definitive diagnosis. In the second report, reverse 
      transcription polymerase chain reaction (RT-PCR) for EWS-FLI1 gene arrangement 
      was done, but the result was negative. Although RT-PCR and fluorescence in situ 
      hybridization (FISH) were performed in the third report, none of the results were 
      shown in the article. Considering that genetic testing is an essential diagnostic 
      tool for certain diseases, such as some brain tumors, we report a case of primary 
      cutaneous extraskeletal EWS, including the result of RT-PCR. A 36-year-old Korean 
      female presented with a cutaneous mass on the abdomen. Histological evaluation 
      revealed solid sheets of primitive, small, uniform cells with hyperchromatic 
      nuclei and scant cytoplasm. Immunohistochemistry stains were positive for CD99 
      and FLI1. RT-PCR showed a t(11;22) EWSR1 (Ewing sarcoma region 1)-FLI1 (Friend 
      leukemia virus integration 1) translocation.
CI  - Copyright (c) The Korean Dermatological Association and The Korean Society for 
      Investigative Dermatology.
FAU - Lee, Jin Wook
AU  - Lee JW
AUID- ORCID: 0000-0002-7956-2860
AD  - Department of Dermatology, Chungbuk National University Hospital, Cheongju, 
      Korea.
FAU - Kim, Dong Min
AU  - Kim DM
AUID- ORCID: 0000-0001-5246-5449
AD  - Department of Dermatology, College of Medicine, Chungbuk National University, 
      Cheongju, Korea.
FAU - Lee, Ji Yeoun
AU  - Lee JY
AUID- ORCID: 0000-0001-9269-6591
AD  - Department of Dermatology, College of Medicine, Chungbuk National University, 
      Cheongju, Korea.
FAU - Yoon, Tae Young
AU  - Yoon TY
AUID- ORCID: 0000-0001-6947-1853
AD  - Department of Dermatology, College of Medicine, Chungbuk National University, 
      Cheongju, Korea.
LA  - eng
PT  - Case Reports
DEP - 20220127
PL  - Korea (South)
TA  - Ann Dermatol
JT  - Annals of dermatology
JID - 8916577
PMC - PMC8831299
OTO - NOTNLM
OT  - EWS protein
OT  - Ewing sarcoma
OT  - Fli-1 transcription factor
OT  - Reverse transcription polymerase chain reaction
COIS- CONFLICTS OF INTEREST: The authors have nothing to disclose.
EDAT- 2022/03/01 06:00
MHDA- 2022/03/01 06:01
PMCR- 2022/02/01
CRDT- 2022/02/28 05:31
PHST- 2020/11/25 00:00 [received]
PHST- 2021/08/29 00:00 [revised]
PHST- 2021/09/01 00:00 [accepted]
PHST- 2022/02/28 05:31 [entrez]
PHST- 2022/03/01 06:00 [pubmed]
PHST- 2022/03/01 06:01 [medline]
PHST- 2022/02/01 00:00 [pmc-release]
AID - 10.5021/ad.2022.34.1.72 [doi]
PST - ppublish
SO  - Ann Dermatol. 2022 Feb;34(1):72-75. doi: 10.5021/ad.2022.34.1.72. Epub 2022 Jan 
      27.