PMID- 35221612
OWN - NLM
STAT- MEDLINE
DCOM- 20220301
LR  - 20220502
IS  - 2413-7170 (Electronic)
IS  - 1029-1857 (Print)
IS  - 1029-1857 (Linking)
VI  - 31
IP  - 5
DP  - 2021 Sep
TI  - Clinical Presentation of Retinoblastoma in Ethiopia: A Case of Jimma University 
      Medical Center Pediatric Oncology Unit, Southwest Ethiopia.
PG  - 963-968
LID - 10.4314/ejhs.v31i5.7 [doi]
AB  - BACKGROUND: Retinoblastoma (RB) is one of the most curable childhood cancers if 
      early detected and treated. Late presentation complicates the management of RB 
      results in dismal treatment outcome. Objective: The aim of this study is to 
      report the clinical presentation pattern of retinoblastoma patients seen at Jimma 
      University Medical center (JUMC). METHODS: The study was a retrospective review 
      of retinoblastoma cases managed at JUMC between August 2016 and July 2020. 
      RESULTS: Among pediatric oncology cases registered retinoblastoma, accounting 8.5 
      % (36/423) of all childhood cancer patients in the study period, 29 (90.6%) of 
      them had unilateral retinoblastoma and 3(9.4%) of them had bilateral 
      retinoblastoma. The average age at presentation for bilateral and unilateral 
      retinoblastoma patients was 17 (range 3-30) months and 37.5 months (range 8-84) 
      respectively. The first symptom observed by the family was leukocoria in 21 
      (65.6%) of the patients but 24(75%) of the patients presented with advanced stage 
      (proptosis and fungating orbital mass) of the disease. The longest and the 
      shortest lag time of presentation from the first symptom was 17 months and 2 
      weeks respectively with the mean lag time of 1.4 months in bilateral and 6 months 
      in unilateral cases. Clinically, the majority of the eyes 24/35(68.6%) were 
      extraocular tumors involving orbital tissues at presentation. CONCLUSION: Most of 
      retinoblastoma patients presented at advanced stage of the disease and presented 
      very late after the family observed the disease. Early detection strategies must 
      be designed by the government and responsible stakeholders in mitigating the 
      effects of late presentation.
CI  - (c) 2021 Diriba Fufa Hordofa, et al.
FAU - Hordofa, Diriba Fufa
AU  - Hordofa DF
AD  - Jimma University, Departement of Pediatrics, Jimma, Ethiopia.
FAU - Daba, Kumale Tolesa
AU  - Daba KT
AD  - Jimma University Departement of ophthalmology. Jimma, Ethiopia.
FAU - Mengesha, Aemero Abateneh
AU  - Mengesha AA
AD  - Bahir Dar University Departement of Ophthalmology, Bahir Dar, Ethiopia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Ethiopia
TA  - Ethiop J Health Sci
JT  - Ethiopian journal of health sciences
JID - 101224773
SB  - IM
MH  - Academic Medical Centers
MH  - Child
MH  - Child, Preschool
MH  - Ethiopia/epidemiology
MH  - Eye/pathology
MH  - Humans
MH  - Infant
MH  - *Retinal Neoplasms/diagnosis/epidemiology/therapy
MH  - *Retinoblastoma/diagnosis/epidemiology/therapy
MH  - Retrospective Studies
PMC - PMC8843152
OTO - NOTNLM
OT  - Retinoblastoma
OT  - leukocoria
OT  - orbital disease
EDAT- 2022/03/01 06:00
MHDA- 2022/03/03 06:00
PMCR- 2021/09/01
CRDT- 2022/02/28 05:31
PHST- 2021/05/21 00:00 [received]
PHST- 2021/05/26 00:00 [accepted]
PHST- 2022/02/28 05:31 [entrez]
PHST- 2022/03/01 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/09/01 00:00 [pmc-release]
AID - jEJHS.v31.i5.pg963 [pii]
AID - 10.4314/ejhs.v31i5.7 [doi]
PST - ppublish
SO  - Ethiop J Health Sci. 2021 Sep;31(5):963-968. doi: 10.4314/ejhs.v31i5.7.