PMID- 35223694
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220301
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 10
DP  - 2022
TI  - Correlation Between Matrix Metalloproteinases With Coronary Artery Lesion Caused 
      by Kawasaki Disease.
PG  - 802217
LID - 10.3389/fped.2022.802217 [doi]
LID - 802217
AB  - This study was designed to clarify the role of matrix metalloproteinases (MMPs) 
      in coronary artery lesions (CAL). Serum samples were acquired from healthy, 
      febrile, and Kawasaki disease (KD) children with or without CAL. Standard blood 
      parameters were examined and enzyme-linked immunosorbent assay (ELISA) was used 
      to assess the levels of MMP-2 and MMP-9. Intravenous immunoglobulin (IVIG) 
      therapy was conducted on the KD patients and the changes of MMPs before and after 
      treatment were compared. The correlations between MMP levels and clinical 
      parameters were also evaluated. Compared to febrile and healthy controls, KD 
      patients demonstrated clinical signs characteristic of abnormal immunoregulation. 
      However, the clinical parameters of KD patients with or without CAL were not 
      significantly different. MMP-2 and MMP-9 levels, however, were significantly 
      higher in KD patients with CAL than those without CAL. IVIG treatment effectively 
      downregulated the levels of MMPs in KD patients, which was more prominent in 
      those with CAL. Significant correlations were found between MMP levels and some 
      clinical parameters of KD, such as fever time, white blood cell count, etc. The 
      upregulation of MMPs significantly correlates with coronary artery aneurysms 
      (CAAs) in KD patients, making it important biomarkers of CAL in KD patients.
CI  - Copyright (c) 2022 Tian, Ma, Zhao, Ji, Wang, Sun and Jiang.
FAU - Tian, Fang
AU  - Tian F
AD  - Heart Center of Women and Children Hospital of Qingdao University, Qingdao, 
      China.
AD  - Department of Pediatric, Maternal and Child Health Hospital, Zibo, China.
FAU - Ma, Linxi
AU  - Ma L
AD  - Nanchang University Queen Mary School, Nanchang, China.
FAU - Zhao, Renbing
AU  - Zhao R
AD  - Department of Pediatric, Maternal and Child Health Hospital, Zibo, China.
FAU - Ji, Lijuan
AU  - Ji L
AD  - Department of Pediatric, Maternal and Child Health Hospital, Zibo, China.
FAU - Wang, Xiufen
AU  - Wang X
AD  - Department of Pediatric, Maternal and Child Health Hospital, Zibo, China.
FAU - Sun, Wenli
AU  - Sun W
AD  - Department of Pediatric, Maternal and Child Health Hospital, Zibo, China.
FAU - Jiang, Yu
AU  - Jiang Y
AD  - Department of Pediatric, Maternal and Child Health Hospital, Zibo, China.
LA  - eng
PT  - Journal Article
DEP - 20220211
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC8874123
OTO - NOTNLM
OT  - IVIG therapy
OT  - KD patients
OT  - Kawasaki disease
OT  - coronary artery lesions
OT  - matrix metalloproteinases
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/01 06:00
MHDA- 2022/03/01 06:01
PMCR- 2022/02/11
CRDT- 2022/02/28 05:39
PHST- 2021/11/01 00:00 [received]
PHST- 2022/01/17 00:00 [accepted]
PHST- 2022/02/28 05:39 [entrez]
PHST- 2022/03/01 06:00 [pubmed]
PHST- 2022/03/01 06:01 [medline]
PHST- 2022/02/11 00:00 [pmc-release]
AID - 10.3389/fped.2022.802217 [doi]
PST - epublish
SO  - Front Pediatr. 2022 Feb 11;10:802217. doi: 10.3389/fped.2022.802217. eCollection 
      2022.