PMID- 35223885 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220502 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 8 DP - 2021 TI - Comparison of a New Optical Biometer That Combines Scheimpflug Imaging With Partial Coherence Interferometry With That of an Optical Biometer Based on Swept-Source Optical Coherence Tomography and Placido-Disk Topography. PG - 814519 LID - 10.3389/fmed.2021.814519 [doi] LID - 814519 AB - PURPOSE: To evaluate measurement precision and to compare the Pentacam AXL (Oculus Optikgerate, Wetzlar, German), a new optical biometer based on Scheimpflug imaging and partial coherence interferometry (PCI) with that of the OA-2000 biometer (Tomey, Nagoya, Japan), which combines swept-source optical coherence tomography (SS-OCT) and Placido-disk topography. METHODS: Axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), aqueous depth (AQD), mean keratometry (Km), astigmatism vectors J0, J45, and corneal diameter (CD) were measured in triplicate by two technical operators. Within-subject standard deviation (Sw), repeatability and reproducibility (2.77 Sw), coefficient of variation (CoV), and intraclass correlation coefficient (ICC) were used to assess the Pentacam AXL intra-observer repeatability and inter-observer reproducibility. Paired t-test and Bland-Altman plots were used to determine the agreement between the two biometers. RESULTS: The new optical biometer had high intra-observer repeatability [all parameters evaluated had low CoV (<0.71%) and high ICC (>0.88)]. Inter-observer reproducibility was also excellent, with high ICC (>0.95) and low CoV (<0.52%). The 95% LoA between the new biometer and OA-2000 were insignificant for most of the parameters evaluated, especially for AL. However, the measurement agreement was moderate for CCT. CONCLUSIONS: Intra-observer repeatability and inter-observer reproducibility were excellent for all parameters evaluated using the new optical biometer based on Scheimpflug imaging and PCI. There was a high agreement between the two devices and hence could be clinically interchangeable for the measurement of most ocular parameters. CI - Copyright (c) 2022 Chen, Zhang, Savini, Zhang, Huang, Yu, Wang, Ning, Huang and Tu. FAU - Chen, Shihao AU - Chen S AD - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University; State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, China. FAU - Zhang, Qiaoyue AU - Zhang Q AD - Department of Ophthalmology, Air Force Medical Center, Beijing, China. FAU - Savini, Giacomo AU - Savini G AD - IRCCS G.B. Bietti Foundation, Rome, Italy. FAU - Zhang, Shuangzhe AU - Zhang S AD - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University; State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, China. FAU - Huang, Xiaomin AU - Huang X AD - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University; State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, China. FAU - Yu, Jinjin AU - Yu J AD - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University; State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, China. FAU - Wang, Yirang AU - Wang Y AD - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University; State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, China. FAU - Ning, Rui AU - Ning R AD - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University; State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, China. FAU - Huang, Jinhai AU - Huang J AD - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University; State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, China. AD - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China. AD - Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China. FAU - Tu, Ruixue AU - Tu R AD - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University; State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, China. LA - eng PT - Journal Article DEP - 20220210 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC8866319 OTO - NOTNLM OT - Scheimpflug imaging OT - agreement OT - repeatability OT - reproducibility OT - swept source optical coherence tomography COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/03/01 06:00 MHDA- 2022/03/01 06:01 PMCR- 2022/02/10 CRDT- 2022/02/28 05:39 PHST- 2021/11/13 00:00 [received] PHST- 2021/12/16 00:00 [accepted] PHST- 2022/02/28 05:39 [entrez] PHST- 2022/03/01 06:00 [pubmed] PHST- 2022/03/01 06:01 [medline] PHST- 2022/02/10 00:00 [pmc-release] AID - 10.3389/fmed.2021.814519 [doi] PST - epublish SO - Front Med (Lausanne). 2022 Feb 10;8:814519. doi: 10.3389/fmed.2021.814519. eCollection 2021.