PMID- 35224027 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220502 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 8 DP - 2021 TI - Hyperhomocysteinemia Increases Risk of Metabolic Syndrome and Cardiovascular Death in an Elderly Chinese Community Population of a 7-Year Follow-Up Study. PG - 811670 LID - 10.3389/fcvm.2021.811670 [doi] LID - 811670 AB - BACKGROUND: Hyperhomocysteinemia (HHcy) and abdominal obesity are risk factors for metabolic syndrome (MetS) and death from cardiovascular disease (CVD). Recent studies have shown a correlation between HHcy and abdominal obesity, suggesting that they may have a combined effect on the risk of MetS and CVD mortality. However, this suspicion remains to be confirmed, particularly in the elderly population. We explored their combined effects on the risk of MetS and CVD mortality among the community population aged 65 and above in China. METHODS AND RESULTS: This prospective study enrolled 3,675 Chinese community residents aged 65 and above in May 2013 with 7-year follow-up of all-cause and CVD mortality. HHcy was defined as the blood homocysteine (Hcy) level >15 mumol/L and abdominal obesity as waist circumference (WC) >/=90 cm for men and >/=80 cm for women (HWC). All participants were grouped into four categories by WC and the blood level of Hcy: NWC (normal WC) /HHcy(-), NWC/HHcy(+), HWC/HHcy(-), and HWC/HHcy(+). The relationship of combined HHcy and abdominal obesity with MetS and metabolic profile was evaluated by logistic regression analysis and the association of combined HHcy and abdominal obesity with CVD and all-cause mortality evaluated by Cox regression analysis. The prevalence of HHcy, abdominal obesity and MetS in elderly Chinese community residents was 40.1, 59.3, and 41.4%, respectively. Using group without HHcy and abdominal obesity [NWC/HHcy(-)] as reference, the participants of other three groups had significantly higher risk of MetS and its component abnormalities, with HWC/HHcy(+) group having the highest risk (OR = 13.52; 95% CI = 8.61-14.55). After a median of 6.94 (+/-1.48) years follow-up, 454 deaths occurred with 135 CVD deaths. Compared with NWC/HHcy(-) group, the risk of 7-year follow-up CVD mortality (HR = 1.75; 95% CI = 1.02-3.03) and all-cause mortality (HR = 1.23; 95% CI = 1.04-2.18) of HWC/HHcy(+) group increased considerably after adjustment for major MetS and CVD risk factors. CONCLUSIONS: There is high prevalence of HHcy, abdominal obesity, and MetS in the elderly Chinese community population. HHcy increases risk of MetS, CVD, and all-cause mortality, especially in the populations with abdominal obesity. CI - Copyright (c) 2022 Liu, Liu, Wang, Chen, Liu, Peng, Pi, Zhang, Tomlinson, Chan, Zhang, Fan, Zheng, Liu and Zhang. FAU - Liu, Chang AU - Liu C AD - Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Liu, Liping AU - Liu L AD - Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Wang, Yinglu AU - Wang Y AD - Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Chen, Xiaoli AU - Chen X AD - Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Liu, Jie AU - Liu J AD - Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Peng, Sheng AU - Peng S AD - Department of Emergency Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Pi, Jingjiang AU - Pi J AD - Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Zhang, Qi AU - Zhang Q AD - Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Tomlinson, Brain AU - Tomlinson B AD - Faculty of Medicine, Macau University of Science and Technology, Macau, China. FAU - Chan, Paul AU - Chan P AD - Division of Cardiology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. FAU - Zhang, Lin AU - Zhang L AD - Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Fan, Huimin AU - Fan H AD - Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Zheng, Liang AU - Zheng L AD - Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Liu, Zhongmin AU - Liu Z AD - Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Zhang, Yuzhen AU - Zhang Y AD - Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. LA - eng PT - Journal Article DEP - 20220210 PL - Switzerland TA - Front Cardiovasc Med JT - Frontiers in cardiovascular medicine JID - 101653388 PMC - PMC8870623 OTO - NOTNLM OT - Chinese elderly population OT - abdominal obesity OT - cardiovascular death OT - hyperhomocysteinemia OT - metabolic syndrome COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/03/01 06:00 MHDA- 2022/03/01 06:01 PMCR- 2021/01/01 CRDT- 2022/02/28 05:40 PHST- 2021/11/17 00:00 [received] PHST- 2021/12/23 00:00 [accepted] PHST- 2022/02/28 05:40 [entrez] PHST- 2022/03/01 06:00 [pubmed] PHST- 2022/03/01 06:01 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fcvm.2021.811670 [doi] PST - epublish SO - Front Cardiovasc Med. 2022 Feb 10;8:811670. doi: 10.3389/fcvm.2021.811670. eCollection 2021.