PMID- 35225227 OWN - NLM STAT- MEDLINE DCOM- 20220301 LR - 20220405 IS - 0392-856X (Print) IS - 0392-856X (Linking) VI - 40 IP - 2 DP - 2022 Feb TI - Measuring change in inclusion body myositis: clinical assessments versus imaging. PG - 404-413 LID - 10.55563/clinexprheumatol/0q2voe [doi] AB - Sporadic inclusion body myositis (sIBM) is a heterogeneous progressive inflammatory muscle disease impacting skeletal muscles in the head, neck, and limbs. Use of valid, reliable, sensitive, and standardised clinical and paraclinical outcome assessments (COA) are critical to inform both proactive clinical care and clinical trial design. Here we review clinical and imaging methods used to quantify muscle strength, size, or function in sIBM, and discuss their application to clinical practice and use in clinical trials. Considerations for future work to validate measures in this population are also discussed. FAU - Alfano, Lindsay N AU - Alfano LN AD - The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Gene Therapy, Columbus, and the Department of Paediatrics, The Ohio State University College of Medicine, Columbus, OH, USA. lindsay.alfano@nationwidechildrens.org. FAU - Focht Garand, Kendrea L AU - Focht Garand KL AD - Department of Speech Pathology and Audiology, University of South Alabama, Mobile, AL, USA. FAU - Malandraki, Georgia A AU - Malandraki GA AD - Department of Speech, Language & Hearing Sciences, Purdue University, West Lafayette, and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. FAU - Salam, Sharfaraz AU - Salam S AD - Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK. FAU - Machado, Pedro M AU - Machado PM AD - Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; Centre for Rheumatology, UCL Division of Medicine, University College London; and NIHR University College London Hospitals Biomedical Research Centre, London, UK. FAU - Dimachkie, Mazen M AU - Dimachkie MM AD - Department of Neurology, The University of Kansas Medical Center, Kansas City, KS, USA. LA - eng PT - Journal Article PT - Review DEP - 20220207 PL - Italy TA - Clin Exp Rheumatol JT - Clinical and experimental rheumatology JID - 8308521 SB - IM MH - Diagnostic Imaging MH - Humans MH - Muscle Strength MH - Muscle, Skeletal/diagnostic imaging MH - *Myositis, Inclusion Body/diagnostic imaging/therapy EDAT- 2022/03/01 06:00 MHDA- 2022/03/03 06:00 CRDT- 2022/02/28 08:56 PHST- 2022/01/20 00:00 [received] PHST- 2022/01/31 00:00 [accepted] PHST- 2022/02/28 08:56 [entrez] PHST- 2022/03/01 06:00 [pubmed] PHST- 2022/03/03 06:00 [medline] AID - 18325 [pii] AID - 10.55563/clinexprheumatol/0q2voe [doi] PST - ppublish SO - Clin Exp Rheumatol. 2022 Feb;40(2):404-413. doi: 10.55563/clinexprheumatol/0q2voe. Epub 2022 Feb 7.