PMID- 35225854
OWN - NLM
STAT- MEDLINE
DCOM- 20220309
LR  - 20230923
IS  - 1536-3708 (Electronic)
IS  - 0148-7043 (Linking)
VI  - 88
IP  - 1s Suppl 1
DP  - 2022 Mar 1
TI  - The Effect of Biological Scaffold (Biodesign) in Postmastectomy Direct-to-Implant 
      Breast Reconstruction: A 5-Year Single-Institution Experience.
PG  - S92-S98
LID - 10.1097/SAP.0000000000003104 [doi]
AB  - BACKGROUND: Direct-to-implant (DTI) breast reconstruction is one of the immediate 
      implant-based breast reconstruction methods. If the amount of soft tissue (eg, 
      muscle or fascia) is insufficient to completely cover the implant, biological 
      scaffold or acellular dermal matrix can be safely used for implant coverage. In 
      this study, we used an acellular porcine small intestinal submucosa (SIS) mesh 
      (Biodesign; Cook Medical Inc, Bloomington, IN) for DTI reconstruction to explore 
      the impact of its use on breast reconstruction results. METHODS: We 
      retrospectively assessed cases involving DTI reconstruction at Taipei Veterans 
      General Hospital from 2015 to 2019. Women, 18 years or older, who underwent 
      immediate DTI reconstruction after mastectomy were included in the study. 
      Mastectomy may have been performed because of therapeutic or prophylactic 
      reasons. Patients who did and did not use SIS mesh for reconstruction were 
      studied separately, and the 2 groups were compared in terms of clinical outcomes 
      and complications. The validated, self-administered BREAST-Q Reconstruction 
      Module version 2.0 survey was used to evaluate health-related quality of life and 
      satisfaction among patients who underwent breast reconstruction. RESULTS: A total 
      of 30 DTI breast reconstructions were enrolled. The mean age was 49.2 years, and 
      the mean body mass index was 22.3 kg/m2. The mean postoperative follow-up 
      duration was 17.1 months. Nipple-sparing mastectomy was performed for 26 cases 
      (86.7%), and DTI breast reconstructions using SIS mesh for implant coverage were 
      done in 14 cases (46.7%). The overall complication rate was 53.3% in 30 
      reconstructions, with nipple complications being the most common complication. 
      The non-SIS and SIS-using groups had a similar overall complication rate 
      postoperatively. As for the quality-of-life assessment, the SIS group obtained a 
      higher score on BREAST-Q than those for whom SIS was not used. CONCLUSIONS: 
      Porcine SIS mesh might be a safe and effective alternative to biological 
      scaffolds in immediate 1-stage implant-based breast reconstruction to improve the 
      quality of life after surgery.
CI  - Copyright (c) 2022 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Sou, Weng-Kit
AU  - Sou WK
FAU - Perng, Cherng-Kang
AU  - Perng CK
FAU - Ma, Hsu
AU  - Ma H
FAU - Tseng, Ling-Ming
AU  - Tseng LM
FAU - Tsai, Yi-Fang
AU  - Tsai YF
FAU - Lin, Yen-Shu
AU  - Lin YS
FAU - Lien, Pei-Ju
AU  - Lien PJ
FAU - Hsiao, Fu-Yin
AU  - Hsiao FY
FAU - Feng, Chin-Jung
AU  - Feng CJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Plast Surg
JT  - Annals of plastic surgery
JID - 7805336
SB  - IM
MH  - *Acellular Dermis
MH  - Animals
MH  - *Breast Implantation/methods
MH  - *Breast Implants/adverse effects
MH  - *Breast Neoplasms/complications
MH  - Female
MH  - Humans
MH  - *Mammaplasty/methods
MH  - Mastectomy/methods
MH  - Middle Aged
MH  - Postoperative Complications/epidemiology/etiology
MH  - Quality of Life
MH  - Retrospective Studies
MH  - Swine
COIS- Conflicts of interest and sources of funding: none declared.
EDAT- 2022/03/01 06:00
MHDA- 2022/03/11 06:00
CRDT- 2022/02/28 12:15
PHST- 2022/02/28 12:15 [entrez]
PHST- 2022/03/01 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
AID - 00000637-202203001-00016 [pii]
AID - 10.1097/SAP.0000000000003104 [doi]
PST - ppublish
SO  - Ann Plast Surg. 2022 Mar 1;88(1s Suppl 1):S92-S98. doi: 
      10.1097/SAP.0000000000003104.