PMID- 35226898
OWN - NLM
STAT- MEDLINE
DCOM- 20220421
LR  - 20240517
IS  - 1421-9824 (Electronic)
IS  - 1420-8008 (Print)
IS  - 1420-8008 (Linking)
VI  - 51
IP  - 1
DP  - 2022
TI  - The Link between APOE4 Presence and Neuropsychological Test Performance among 
      Mexican Americans and Non-Hispanic Whites of the Multiethnic Health & Aging 
      Brain Study - Health Disparities Cohort.
PG  - 26-31
LID - 10.1159/000521898 [doi]
AB  - INTRODUCTION: The APOEepsilon4 allele is the single strongest genetic risk for 
      late-onset Alzheimer's disease (AD). Prior work demonstrates that not only the 
      APOEepsilon4 allele varies by race/ethnicity but also the risk for AD and cognitive 
      impairment conveyed by the APOEepsilon4 allele varies by the racial/ethnic group as 
      well as genetic ancestry. Here, we sought to examine the link between the APOEepsilon4 
      and neuropsychological functioning among Mexican Americans (MAs). METHODS: Data 
      were examined from 1,633 (852 MAs and 781 non-Hispanic Whites [NHWs]) 
      participants of the Health & Aging Brain Study - Health Disparities (HABS-HD) 
      and were enrolled with all requisite data to be included into the current 
      analyses. RESULTS: The frequency of both epsilon4 and epsilon2 alleles was significantly 
      lower among MAs as compared to NHWs. Among MAs, APOEepsilon4 allele presence was 
      associated specifically with poorer immediate and delayed memory (Wechsler Memory 
      Scale - Third Edition [WMS-III] Logical Memory and Spanish-English Verbal 
      Learning Test [SEVLT]). Among NHWs, APOEepsilon4 allele presence was associated with 
      poorer immediate and delayed memory as well as worse executive functioning 
      (Trials B) and verbal fluency (Animal naming). DISCUSSION/CONCLUSION: The APOEepsilon4 
      allele was associated with poorer cognition across multiple domains among NHWs; 
      however, allele presence was specifically associated with poorer memory 
      performance among MAs. When combined with prior work, the current findings 
      demonstrate that the risk factors associated with cognitive dysfunction differ 
      among MAs as compared to NHWs and require additional investigation.
CI  - (c) 2022 S. Karger AG, Basel.
FAU - O'Bryant, Sid E
AU  - O'Bryant SE
AD  - Institute for Translational Research, University of North Texas Health Science 
      Center, Fort Worth, Texas, USA.
FAU - Barber, Robert C
AU  - Barber RC
AD  - Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center, Fort Worth, Texas, USA.
FAU - Philips, Nicole
AU  - Philips N
AD  - Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center, Fort Worth, Texas, USA.
FAU - Johnson, Leigh A
AU  - Johnson LA
AD  - Institute for Translational Research, University of North Texas Health Science 
      Center, Fort Worth, Texas, USA.
AD  - Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center, Fort Worth, Texas, USA.
FAU - Hall, James R
AU  - Hall JR
AD  - Institute for Translational Research, University of North Texas Health Science 
      Center, Fort Worth, Texas, USA.
FAU - Subasinghe, Kumudu
AU  - Subasinghe K
AD  - Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center, Fort Worth, Texas, USA.
FAU - Petersen, Melissa
AU  - Petersen M
AD  - Institute for Translational Research, University of North Texas Health Science 
      Center, Fort Worth, Texas, USA.
AD  - Department of Family Medicine, University of North Texas Health Science Center, 
      Fort Worth, Texas, USA.
FAU - Toga, Arthur W
AU  - Toga AW
AD  - Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, 
      Keck School of Medicine of USC, University of Southern California, Las Angeles, 
      California, USA.
FAU - Yaffe, Kristine
AU  - Yaffe K
AD  - Department of Psychiatry, Neurology, and Epidemiology and Biostatistics, 
      University of California, San Francisco, California, USA.
AD  - San Francisco VA Medical Center, San Francisco, California, USA.
FAU - Rissman, Robert A
AU  - Rissman RA
AD  - Department of Neurosciences, University of California, San Diego, La Jolla, 
      California, USA.
AD  - Veterans Affairs San Diego Healthcare System, San Diego, California, USA.
CN  - HABS-HD Study Team
LA  - eng
GR  - R01 AG054073/AG/NIA NIH HHS/United States
GR  - P30 AG066530/AG/NIA NIH HHS/United States
GR  - R01 AG058533/AG/NIA NIH HHS/United States
GR  - U19 AG078109/AG/NIA NIH HHS/United States
GR  - R35 AG071916/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220228
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
RN  - 0 (Apolipoprotein E4)
SB  - IM
MH  - Aging/genetics
MH  - *Alzheimer Disease/genetics/psychology
MH  - *Apolipoprotein E4/genetics
MH  - Brain
MH  - Ethnicity
MH  - Humans
MH  - Mexican Americans/genetics
MH  - Neuropsychological Tests
PMC - PMC9175651
MID - NIHMS1804508
OTO - NOTNLM
OT  - APOE4
OT  - Alzheimer's disease
OT  - Cognition
OT  - Health disparities
OT  - Mexican American
COIS- Conflict of Interest Statement SEO has multiple patents on precision medicine for 
      neurodegenerative diseases and is the founding scientist of Cx Precision 
      Medicine. No other authors reported any potential conflicts of interest.
EDAT- 2022/03/01 06:00
MHDA- 2022/04/22 06:00
PMCR- 2022/06/08
CRDT- 2022/02/28 20:03
PHST- 2021/12/07 00:00 [received]
PHST- 2022/01/01 00:00 [accepted]
PHST- 2022/03/01 06:00 [pubmed]
PHST- 2022/04/22 06:00 [medline]
PHST- 2022/02/28 20:03 [entrez]
PHST- 2022/06/08 00:00 [pmc-release]
AID - 000521898 [pii]
AID - 10.1159/000521898 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2022;51(1):26-31. doi: 10.1159/000521898. Epub 2022 
      Feb 28.