PMID- 35227147
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20220726
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 63
IP  - 7
DP  - 2022 Jul
TI  - Characterization of low-grade arthralgia, myalgia, and musculoskeletal pain with 
      ibrutinib therapy: pooled analysis of clinical trials in patients with chronic 
      lymphocytic leukemia and mantle cell lymphoma.
PG  - 1580-1588
LID - 10.1080/10428194.2022.2038372 [doi]
AB  - Joint and muscle pain, including arthralgia, myalgia, and musculoskeletal pain, 
      are among the common adverse events (AEs) reported for ibrutinib, a once-daily 
      Bruton's tyrosine kinase inhibitor approved for the treatment of various B-cell 
      malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell 
      lymphoma (MCL). This pooled analysis from nine clinical trials of ibrutinib in 
      CLL and MCL (N = 1178) evaluated patterns of these AEs. Any grade arthralgia, 
      myalgia, and musculoskeletal pain occurred in 18%, 10%, and 6% of patients, 
      respectively. AEs were primarily low-grade (grade 1/2: 97‒99%) and occurred 
      during the first year of treatment; most resolved (67%-80%) at first occurrence. 
      Few (<5%) patients required ibrutinib dose modification; no patients discontinued 
      ibrutinib due to these AEs. Among patients evaluated for concomitant medication 
      use, all those receiving concomitant medications after the first AE occurrence 
      experienced AE resolution. These data suggest that these AEs were not 
      treatment-limiting during ibrutinib therapy.
FAU - Siddiqi, Tanya
AU  - Siddiqi T
AD  - City of Hope National Medical Center, Duarte, CA, USA.
FAU - Coutre, Steven
AU  - Coutre S
AUID- ORCID: 0000-0001-8420-5748
AD  - Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA, 
      USA.
FAU - McKinney, Matthew
AU  - McKinney M
AD  - Duke University, Durham, NC, USA.
FAU - Barr, Paul M
AU  - Barr PM
AUID- ORCID: 0000-0002-9733-401X
AD  - Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, 
      USA.
FAU - Rogers, Kerry
AU  - Rogers K
AD  - Ohio State University, Columbus, OH, USA.
FAU - Mokatrin, Ahmad
AU  - Mokatrin A
AD  - Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA, USA.
FAU - Valentino, Rudy
AU  - Valentino R
AD  - Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA, USA.
FAU - Szoke, Anita
AU  - Szoke A
AD  - Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA, USA.
FAU - Deshpande, Sanjay
AU  - Deshpande S
AD  - Johnson & Johnson, Raritan, NJ, USA.
FAU - Zhu, Angeline
AU  - Zhu A
AD  - Johnson & Johnson, Raritan, NJ, USA.
FAU - Arango-Hisijara, Israel
AU  - Arango-Hisijara I
AD  - Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA, USA.
FAU - Osei-Bonsu, Kojo
AU  - Osei-Bonsu K
AD  - Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA, USA.
FAU - Wang, Michael
AU  - Wang M
AUID- ORCID: 0000-0001-9748-5486
AD  - The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
FAU - O'Brien, Susan
AU  - O'Brien S
AD  - UC Irvine, Chao Family Comprehensive Cancer Center, Irvine, CA, USA.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220228
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Piperidines)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Pyrazoles)
RN  - 0 (Pyrimidines)
RN  - 1X70OSD4VX (ibrutinib)
RN  - JAC85A2161 (Adenine)
SB  - IM
MH  - Adenine/analogs & derivatives
MH  - Adult
MH  - Arthralgia/chemically induced/drug therapy
MH  - Humans
MH  - *Leukemia, Lymphocytic, Chronic, B-Cell/complications/diagnosis/drug therapy
MH  - *Lymphoma, Mantle-Cell/drug therapy/pathology
MH  - *Musculoskeletal Pain/chemically induced/diagnosis
MH  - Myalgia/chemically induced/diagnosis
MH  - Piperidines
MH  - Protein Kinase Inhibitors/adverse effects
MH  - Pyrazoles/adverse effects
MH  - Pyrimidines/adverse effects
OTO - NOTNLM
OT  - Ibrutinib
OT  - arthralgia
OT  - chronic lymphocytic leukemia
OT  - mantle cell lymphoma
OT  - musculoskeletal pain
OT  - myalgia
EDAT- 2022/03/02 06:00
MHDA- 2022/07/14 06:00
CRDT- 2022/03/01 05:42
PHST- 2022/03/02 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/03/01 05:42 [entrez]
AID - 10.1080/10428194.2022.2038372 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2022 Jul;63(7):1580-1588. doi: 10.1080/10428194.2022.2038372. Epub 
      2022 Feb 28.