PMID- 35227230
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220318
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Feb 28
TI  - Elevated blood urea nitrogen-to-creatinine ratio increased the risk of Coronary 
      Artery Disease in patients living with type 2 diabetes mellitus.
PG  - 50
LID - 10.1186/s12902-022-00954-3 [doi]
LID - 50
AB  - BACKGROUND: High Blood Urea Nitrogen (BUN) and high Serum Creatinine (SCr) levels 
      are risk factors for Coronary Artery Disease (CAD). However, the relationship 
      between the Blood Urea Nitrogen to Creatinine (BUN/SCr) ratio (UCR) and the risk 
      of CAD in patients living with new-onset diabetes is unclear. This study aimed to 
      examine the relationship between blood UCR and the risk of CAD in patients living 
      with new-onset type 2 diabetes mellitus (T2DM). METHODS: We analyzed the data 
      from the cohort of 12,299 patients living with type 2 diabetes mellitus. Primary 
      endpoints were the events of CAD. The ANOVA test (continuous indicators) and chi(2) 
      test (categorical indicators) were used to assess the differences of baseline 
      characteristics across the groups of UCR. In order to understand the correlation 
      between variables, we performed correlation analysis on variables that have 
      significant differences between CAD group and non-CAD group. 
      Multivariate-adjusted Cox proportional hazard regression models were applied to 
      estimate the association of the blood UCR with the risk of CAD in patients living 
      with T2DM. The Kaplan-Meier survival function plotting and the log-rank test were 
      used to evaluate the event-free survival according to the groups of UCR. The 
      restricted cubic spline model was used to show the adjusted association between 
      blood UCR and risk of CAD in patients living with T2DM. RESULTS: During a median 
      follow-up of 2.66 years, 1173 CAD were recorded with an event rate of 28.49 
      events per 1000 person-years. In multivariate-adjusted Cox regression models, 
      elevated blood urea nitrogen to creatinine ratio (UCR) was associated with higher 
      risk of CAD in patients living with T2DM [hazard ratio (HR), 1.782; 95% 
      confidence interval (CI), 1.237-2.567]. The Kaplan-Meier survival curves 
      indicated that the high group of UCR tended to have a lower event-free survival 
      than the low group and medium group. There was a nonlinear trend toward 
      increasing risk of CAD across the groups of UCR. And cubic spline function graph 
      suggested that the influence of UCR level on HR for CAD increased significantly 
      at UCR levels above 6.67. CONCLUSIONS: An elevated UCR was significantly 
      associated with an increased risk for CAD in patients living with T2DM.
CI  - (c) 2022. The Author(s).
FAU - Liu, Feng
AU  - Liu F
AD  - Center for Quality Control and Improvement of Physical Examination, Beijing 
      Physical Examination Center, No. 1, Yard 81, Fucheng Road, Beijing, Haidian 
      District, China. liufeng@bjtjzx.com.
FAU - Ma, Guanhui
AU  - Ma G
AD  - Research Center of Digital Health China, Health and Medical Research Institute, 
      Jinan, China.
AD  - Department of Big Data, Kangping Medical Health Co. Ltd, Jinan, China.
FAU - Tong, Chao
AU  - Tong C
AD  - School of Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen, 
      Beijing, 100069, China.
FAU - Zhang, Shan
AU  - Zhang S
AD  - School of Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen, 
      Beijing, 100069, China.
FAU - Yang, Xinghua
AU  - Yang X
AD  - School of Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen, 
      Beijing, 100069, China. xinghuayang@ccmu.edu.cn.
FAU - Xu, Cong
AU  - Xu C
AD  - Department of Big Data, Kangping Medical Health Co. Ltd, Jinan, China.
FAU - Yang, Weihao
AU  - Yang W
AD  - Research Center of Digital Health China, Health and Medical Research Institute, 
      Jinan, China.
FAU - Xia, Guobao
AU  - Xia G
AD  - Center for Quality Control and Improvement of Physical Examination, Beijing 
      Physical Examination Center, No. 1, Yard 81, Fucheng Road, Beijing, Haidian 
      District, China.
FAU - Li, Mingliang
AU  - Li M
AD  - Center for Quality Control and Improvement of Physical Examination, Beijing 
      Physical Examination Center, No. 1, Yard 81, Fucheng Road, Beijing, Haidian 
      District, China.
LA  - eng
GR  - 2018-1-2241/Research Special Fund of Capital Health Development/
PT  - Journal Article
DEP - 20220228
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Blood Urea Nitrogen
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Coronary Artery Disease/*blood/*epidemiology
MH  - Creatinine/*blood
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Survival Analysis
PMC - PMC8883664
OTO - NOTNLM
OT  - CAD
OT  - Cox regression
OT  - Cubic spline function
OT  - Kaplan-Meier survival
OT  - T2DM
OT  - UCR
COIS- The authors declare that they have no competing interests.
EDAT- 2022/03/02 06:00
MHDA- 2022/03/19 06:00
PMCR- 2022/02/28
CRDT- 2022/03/01 05:42
PHST- 2021/07/05 00:00 [received]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/03/01 05:42 [entrez]
PHST- 2022/03/02 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2022/02/28 00:00 [pmc-release]
AID - 10.1186/s12902-022-00954-3 [pii]
AID - 954 [pii]
AID - 10.1186/s12902-022-00954-3 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2022 Feb 28;22(1):50. doi: 10.1186/s12902-022-00954-3.