PMID- 35227320
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220308
IS  - 2056-9920 (Print)
IS  - 2056-9920 (Electronic)
IS  - 2056-9920 (Linking)
VI  - 8
IP  - 1
DP  - 2022 Feb 28
TI  - Optical coherence tomography in diagnosing polypoidal choroidal vasculopathy. 
      Looking into the future: a systematic review and meta-analysis.
PG  - 14
LID - 10.1186/s40942-022-00365-5 [doi]
LID - 14
AB  - BACKGROUND: Polypoidal choroidal vasculopathy (PCV) is an exudative maculopathy 
      with features similar to wet age macular degeneration. The incidence of PCV is 
      known to be higher in the Asian population compared to Caucasians. Imaging 
      modality is needed to make the diagnosis of PCV. Although Indocyanine green 
      angiography (ICGA) is still the gold standard, it is not routinely performed in 
      vitreoretinal practice. Thus another imaging modality is currently a popular 
      research area. Spectral domain optical coherence tomography (SD-OCT) has emerged 
      as a new imaging modality mostly available in clinics. Some studies have reported 
      the sensitivity and specificity of SD-OCT in diagnosing PCV with different 
      results and thresholds. METHODS: Relevant studies from PubMed, Science Direct and 
      Google Scholar databases were systematically searched. In random effect models 
      using STATA 14 software, a meta-analysis was performed to determine the pooled 
      diagnostic accuracy. QUADAS 2 was used to evaluate the risk of bias of each study 
      by Revman 5.4 software. RESULTS: Seven eligible studies which met the inclusion 
      and exclusion criteria were enrolled in this study. A total of 911 eyes were 
      included to investigate the diagnostic accuracy of SD-OCT. As a result, the 
      pooled sensitivity was 0.91 (95% CI 0.87-0.93), specificity 0.88 (95% 0.83-0.92), 
      positive likelihood ratio 8, negative likelihood ratio 11, the area under the 
      summary receiver operating characteristic curve 0.95 (95% CI 0.93-0.97), and 
      diagnostic odds ratio 71.81 (95% CI 38.89-132.74). CONCLUSION: SD-OCT provided a 
      high diagnostic value for detecting PCV. Sharply peaked pigment epithelial 
      detachment (PED), notched PED, bubble sign, multiple PED, and double-layer sign 
      were the most common features found in PCV.
CI  - (c) 2022. The Author(s).
FAU - Permadi, Annisa C
AU  - Permadi AC
AUID- ORCID: 0000-0001-9385-4264
AD  - Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Cipto 
      Mangunkusumo Kirana Eye Hospital, Jakarta, Indonesia. annpermadi@gmail.com.
FAU - Djatikusumo, Ari
AU  - Djatikusumo A
AD  - Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Cipto 
      Mangunkusumo Kirana Eye Hospital, Jakarta, Indonesia.
FAU - Adriono, Gitalisa Andayani
AU  - Adriono GA
AD  - Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Cipto 
      Mangunkusumo Kirana Eye Hospital, Jakarta, Indonesia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220228
PL  - England
TA  - Int J Retina Vitreous
JT  - International journal of retina and vitreous
JID - 101677897
PMC - PMC8883730
OTO - NOTNLM
OT  - Diagnosis
OT  - Indocyanine green angiography (ICGA)
OT  - Meta-analysis
OT  - Optical coherence tomography (OCT)
OT  - Polypoidal choroidal vasculopathy
COIS- We would like to give the following facts which may be considered as potential 
      conflict to this work. We wish to confirm that there are no known conflict of 
      interest in our publication, therefore we ensures that the publisher has the 
      author's license of copyright and permission to publish the studies.
EDAT- 2022/03/02 06:00
MHDA- 2022/03/02 06:01
PMCR- 2022/02/28
CRDT- 2022/03/01 05:43
PHST- 2021/11/25 00:00 [received]
PHST- 2022/02/14 00:00 [accepted]
PHST- 2022/03/01 05:43 [entrez]
PHST- 2022/03/02 06:00 [pubmed]
PHST- 2022/03/02 06:01 [medline]
PHST- 2022/02/28 00:00 [pmc-release]
AID - 10.1186/s40942-022-00365-5 [pii]
AID - 365 [pii]
AID - 10.1186/s40942-022-00365-5 [doi]
PST - epublish
SO  - Int J Retina Vitreous. 2022 Feb 28;8(1):14. doi: 10.1186/s40942-022-00365-5.