PMID- 35228576
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20220412
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Feb 28
TI  - Brain lipidomics and neurodevelopmental outcomes in intrauterine growth 
      restricted piglets fed dairy or vegetable fat diets.
PG  - 3303
LID - 10.1038/s41598-022-07133-3 [doi]
LID - 3303
AB  - Breast milk has neurodevelopmental advantages compared to infant formula, 
      especially in low-birth-weight infants, which may in part relate to the fat 
      source. This study compared neurodevelopmental outcomes in three-day-old normal 
      birth weight (NBW) and intrauterine growth restricted (IUGR) piglets fed a 
      formula diet with either vegetable oil (VEG) or bovine milk fat sources (MILK) 
      for three weeks in a 2 x 2 factorial design. Behavioural tests, lipidomics, MRI 
      and RNA sequencing analyses of plasma and brain tissue were conducted. The 
      absolute levels of 82% and 11% of lipid molecules were different between dietary 
      groups in plasma and hippocampus, respectively. Of the lipid molecules with 
      differential abundance in the hippocampus, the majority were upregulated in MILK 
      versus VEG, and they mainly belonged to the group of glycerophospholipids. Lower 
      absolute brain weights, absolute grey and white matter volumes and behaviour and 
      motor function scores, and higher relative total brain weights were present in 
      IUGR compared to NBW with minor influence of diet. Cognitive function and 
      cerebellar gene expression profiles were similar for dietary and weight groups, 
      and overall only minor interactive effects between diet and birth weight were 
      observed. Overall, we show that the dietary fat source influences the plasma and 
      to a lesser degree the hippocampal lipidome and is unable to improve on 
      IUGR-induced brain structural and functional impairments.
CI  - (c) 2022. The Author(s).
FAU - Henriksen, Nicole L
AU  - Henriksen NL
AD  - Section of Comparative Pediatrics and Nutrition, Department of Veterinary and 
      Animal Sciences, University of Copenhagen, Dyrlaegevej 68, 1870, Frederiksberg C, 
      Denmark.
FAU - Asmussen, Karina S
AU  - Asmussen KS
AD  - Section of Comparative Pediatrics and Nutrition, Department of Veterinary and 
      Animal Sciences, University of Copenhagen, Dyrlaegevej 68, 1870, Frederiksberg C, 
      Denmark.
FAU - Pan, Xiaoyu
AU  - Pan X
AD  - Section of Comparative Pediatrics and Nutrition, Department of Veterinary and 
      Animal Sciences, University of Copenhagen, Dyrlaegevej 68, 1870, Frederiksberg C, 
      Denmark.
FAU - Jiang, Ping-Ping
AU  - Jiang PP
AD  - Section of Comparative Pediatrics and Nutrition, Department of Veterinary and 
      Animal Sciences, University of Copenhagen, Dyrlaegevej 68, 1870, Frederiksberg C, 
      Denmark.
FAU - Mori, Yuki
AU  - Mori Y
AD  - Center for Translational Neuromedicine, University of Copenhagen, Blegdamsvej 3B, 
      2200, Copenhagen N, Denmark.
FAU - Christiansen, Line I
AU  - Christiansen LI
AD  - Section of Comparative Pediatrics and Nutrition, Department of Veterinary and 
      Animal Sciences, University of Copenhagen, Dyrlaegevej 68, 1870, Frederiksberg C, 
      Denmark.
FAU - Sprenger, Richard R
AU  - Sprenger RR
AD  - Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical 
      Sciences, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
FAU - Ejsing, Christer S
AU  - Ejsing CS
AD  - Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical 
      Sciences, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
FAU - Pankratova, Stanislava
AU  - Pankratova S
AD  - Section of Comparative Pediatrics and Nutrition, Department of Veterinary and 
      Animal Sciences, University of Copenhagen, Dyrlaegevej 68, 1870, Frederiksberg C, 
      Denmark.
FAU - Thymann, Thomas
AU  - Thymann T
AD  - Section of Comparative Pediatrics and Nutrition, Department of Veterinary and 
      Animal Sciences, University of Copenhagen, Dyrlaegevej 68, 1870, Frederiksberg C, 
      Denmark. thomas.thymann@sund.ku.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220228
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Animals
MH  - Birth Weight
MH  - Brain/diagnostic imaging/metabolism
MH  - Diet
MH  - Dietary Fats
MH  - Fetal Growth Retardation/metabolism
MH  - Humans
MH  - *Lipidomics
MH  - Swine
MH  - *Vegetables
PMC - PMC8885751
COIS- The authors declare no competing interests.
EDAT- 2022/03/02 06:00
MHDA- 2022/04/13 06:00
PMCR- 2022/02/28
CRDT- 2022/03/01 05:55
PHST- 2021/11/05 00:00 [received]
PHST- 2022/02/14 00:00 [accepted]
PHST- 2022/03/01 05:55 [entrez]
PHST- 2022/03/02 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2022/02/28 00:00 [pmc-release]
AID - 10.1038/s41598-022-07133-3 [pii]
AID - 7133 [pii]
AID - 10.1038/s41598-022-07133-3 [doi]
PST - epublish
SO  - Sci Rep. 2022 Feb 28;12(1):3303. doi: 10.1038/s41598-022-07133-3.