PMID- 35231034
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20220310
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 3
DP  - 2022
TI  - Towards better reliability in fetal heart rate variability using time domain and 
      spectral domain analyses. A new method for assessing fetal neurological state?
PG  - e0263272
LID - 10.1371/journal.pone.0263272 [doi]
LID - e0263272
AB  - OBJECTIVES: Fetal heart rate variability (FHRV) has shown potential in fetal 
      surveillance. Therefore, we aimed to evaluate the reliability of time domain and 
      spectral domain parameters based on non-invasive fetal electrocardiography 
      (NI-FECG). METHOD: NI-FECG, with a sampling frequency of 1 kHz, was obtained in 
      75 healthy, singleton pregnant women between gestational age (GA) 20+0 to 41+0. 
      The recording was divided into a) heart rate pattern (HRP) and b) periods 
      fulfilling certain criteria of stationarity of RR-intervals, termed stationary 
      heart rate pattern (SHRP). Within each recording, the first and the last time 
      series from each HRP with less than 5% artifact correction were analyzed and 
      compared. Standard deviation of normal-to-normal RR-intervals (SDNN), root mean 
      square of successive differences (RMSSD), high frequency power (HF-power), low 
      frequency power (LF-power), and LF-power/HF-power were performed. A multivariate 
      mixed model was used and acceptable reliability was defined as intraclass 
      correlation coefficient (ICC) >/= 0.80 and a coefficient of variation (CV) </= 15%. 
      Based on these results, the CV and ICC were computed if the average of two to six 
      time series was used. RESULTS: For GA 28+0 to 34+6, SDNN and RMSSD exhibited 
      acceptable reliability (CV < 15%; ICC > 90%), whereas GA 35+0 to 41+0and 20+0 to 
      27+6 showed higher CVs. Spectral domain parameters also showed high CVs However, 
      by using the mean value of two to six time series, acceptable reliability in 
      SDNN, RMSSD and HF-power from GA 28+0 was achieved. Stationarity of RR-intervals 
      showed high influence on reliability and SHRP was superior to HRP, whereas the 
      length of the time series showed minor influence. CONCLUSION: Acceptable 
      reliability seems achievable in SDNN, RMSSD and HF-power from gestational week 
      28. However, stationarity of RR-intervals should be considered when selecting 
      time series for analyses.
FAU - Zizzo, Anne Rahbek
AU  - Zizzo AR
AUID- ORCID: 0000-0003-0342-0708
AD  - Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus N, 
      Denmark.
FAU - Kirkegaard, Ida
AU  - Kirkegaard I
AD  - Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus N, 
      Denmark.
FAU - Uldbjerg, Niels
AU  - Uldbjerg N
AD  - Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus N, 
      Denmark.
FAU - Hansen, John
AU  - Hansen J
AD  - Department of Health Science and Technology, Aalborg University, Aalborg, 
      Denmark.
FAU - Molgaard, Henning
AU  - Molgaard H
AD  - Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220301
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - *Heart Rate, Fetal
PMC - PMC8887753
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/03/02 06:00
MHDA- 2022/03/11 06:00
PMCR- 2022/03/01
CRDT- 2022/03/01 17:12
PHST- 2021/06/22 00:00 [received]
PHST- 2022/01/14 00:00 [accepted]
PHST- 2022/03/01 17:12 [entrez]
PHST- 2022/03/02 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2022/03/01 00:00 [pmc-release]
AID - PONE-D-21-20436 [pii]
AID - 10.1371/journal.pone.0263272 [doi]
PST - epublish
SO  - PLoS One. 2022 Mar 1;17(3):e0263272. doi: 10.1371/journal.pone.0263272. 
      eCollection 2022.