PMID- 35231090
OWN - NLM
STAT- MEDLINE
DCOM- 20220428
LR  - 20220428
IS  - 1468-2834 (Electronic)
IS  - 0002-0729 (Linking)
VI  - 51
IP  - 3
DP  - 2022 Mar 1
TI  - Functional health index of intrinsic capacity: multi-domain operationalisation 
      and validation in the Singapore Longitudinal Ageing Study (SLAS2).
LID - afac011 [pii]
LID - 10.1093/ageing/afac011 [doi]
AB  - BACKGROUND: ad hoc approaches are used to create composite indexes of intrinsic 
      capacity (IC) based on five domains recommended by the World Health Organization 
      for healthy ageing. We examined how combinations of domain-specific measures 
      determine measurement performances of composite IC indexes. METHODS: in this 
      population-based prospective cohort study, community-dwelling older persons 
      (N = 2,906) aged 55 years and above were recruited. We used 12 domain-specific 
      measures: cognition (Mini-Mental State Examination, MMSE), psychological 
      (Geriatric Depression Scale, GDS), locomotion (Timed Up-and Go [TUG], GV, Knee 
      Extension Strength, Performance Orientated Mobility Assessment), sensory 
      (logarithm of the Minimum Angle of Resolution [LogMAR] vision and Whisper Test 
      hearing) and vitality (forced expiratory volume in 1 second pulmonary function, 
      Elderly Nutritional Indicators for Geriatric Malnutrition Assessment [ENIGMA], 
      Nutritional Screening Initiative) to derive 144 composite 2- to 5-domain 
      functional health indexes (FHI), and evaluated their abilities to predict 9-year 
      mortality and their associations with health determinants. RESULTS: with 5-domain 
      FHI, TUG, logMAR and MMSE showed the largest factor loadings (0.65-0.75). All 
      single-domain FHI were significantly associated with mortality risks. Area under 
      the receiver operating characteristic curve (AUC) values of mortality prediction 
      increased with the number of domains (from mean 0.615 for single-domain FHI to 
      mean 0.705 for 5-domain FHI), but the difference between 3-domain versus 4-domain 
      FHI (P = 0.082) or versus 5-domain FHI (P = 0.109) was not statistically 
      significant. Highest AUCs (P < 0.001) of best performing FHI were single-domain 
      TUG: 0.735; 2-domain TUG + ENIGMA: 0.743; 3-domain TUG + LogMAR + ENIGMA: 0.762; 
      4-domain TUG + MMSE + LogMAR + ENIGMA: 0.757; 5-domain 
      TUG + MMSE + GDS + LogMAR + ENIGMA: 0.751. FHI showed excellent construct 
      validity based on correlations with known health determinants. CONCLUSIONS: among 
      Singaporean older adults, cognition, sensory and locomotion are predominant IC 
      domains. A multi-domain IC index performs better with more domain measures, but a 
      minimalist 3-domain index performs just as robustly as a 4- or 5-domain index.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      British Geriatrics Society. All rights reserved. For permissions, please email: 
      journals.permissions@oup.com.
FAU - Cheong, Chin Yee
AU  - Cheong CY
AD  - Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore, Singapore.
FAU - Yap, Philip
AU  - Yap P
AD  - Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore, Singapore.
FAU - Nyunt, Ma Shwe Zin
AU  - Nyunt MSZ
AD  - Gerontology Research Programme, Department of Psychological Medicine, Yong Loo 
      Lin School of Medicine, National University of Singapore, Singapore, Singapore.
FAU - Qi, Gao
AU  - Qi G
AD  - Gerontology Research Programme, Department of Psychological Medicine, Yong Loo 
      Lin School of Medicine, National University of Singapore, Singapore, Singapore.
FAU - Gwee, Xinyi
AU  - Gwee X
AD  - Gerontology Research Programme, Department of Psychological Medicine, Yong Loo 
      Lin School of Medicine, National University of Singapore, Singapore, Singapore.
FAU - Wee, Shiou Liang
AU  - Wee SL
AD  - Health and Social Sciences Cluster, Singapore Institute of Technology, Singapore, 
      Singapore.
FAU - Yap, Keng Bee
AU  - Yap KB
AD  - Department of Medicine, Ng Teng Fong Hospital, Singapore, Singapore.
FAU - Ng, Tze Pin
AU  - Ng TP
AD  - Gerontology Research Programme, Department of Psychological Medicine, Yong Loo 
      Lin School of Medicine, National University of Singapore, Singapore, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Age Ageing
JT  - Age and ageing
JID - 0375655
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging
MH  - Geriatric Assessment
MH  - Humans
MH  - *Malnutrition
MH  - *Nutrition Assessment
MH  - Nutritional Status
MH  - Prospective Studies
MH  - Singapore/epidemiology
OTO - NOTNLM
OT  - community-dwelling
OT  - healthy ageing
OT  - intrinsic capacity
OT  - older people
OT  - validation
EDAT- 2022/03/02 06:00
MHDA- 2022/04/29 06:00
CRDT- 2022/03/01 17:12
PHST- 2021/08/21 00:00 [received]
PHST- 2022/03/01 17:12 [entrez]
PHST- 2022/03/02 06:00 [pubmed]
PHST- 2022/04/29 06:00 [medline]
AID - 6540133 [pii]
AID - 10.1093/ageing/afac011 [doi]
PST - ppublish
SO  - Age Ageing. 2022 Mar 1;51(3):afac011. doi: 10.1093/ageing/afac011.