PMID- 35232804
OWN - NLM
STAT- MEDLINE
DCOM- 20221025
LR  - 20221109
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 49
IP  - 9
DP  - 2022 Sep
TI  - Frequency of Symptomatic Adverse Events in Rheumatoid Arthritis: An Exploratory 
      Online Survey.
PG  - 998-1005
LID - 10.3899/jrheum.210688 [doi]
AB  - OBJECTIVE: To generate initial data on the frequency and effect of symptomatic 
      adverse events (AEs) associated with rheumatoid arthritis (RA) drug therapy from 
      the patient perspective. METHODS: We conducted an exploratory online survey 
      asking patients with RA to indicate whether they currently or had ever 
      experienced the 80 different symptomatic AEs included in the Patient-Reported 
      Outcomes of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). 
      Results were summarized to report their frequency, and regression models were 
      used to estimate their associations with RA medication use and overall bother. 
      RESULTS: The 560 patients who completed the survey and reported taking >/= 1 RA 
      medication (disease-modifying antirheumatic drugs [DMARDs], steroids, 
      nonsteroidal antiinflammatory drugs [NSAIDs]), had a mean disease duration of 8 
      years, and were on a wide range of DMARDs. The number of symptomatic AEs 
      experienced in the past 7 days was none (6%), 1-10 (28%), 11-20 (28%), and > 
      20 (38%). Overall, most participants reported that side effects bothered them 
      somewhat (28%), quite a bit (24%), or very much (15%). In multivariable 
      regression analyses, current prednisone and NSAID use were associated with the 
      greatest number of current side effects (26 and 22, respectively). Many of the 
      strongest associations between current symptomatic AEs and medication use aligned 
      with known side effect profiles. CONCLUSION: In this exploratory online survey, 
      patients with RA reported frequent symptomatic AEs with their medications that 
      are bothersome. Further work is needed to develop and validate a measure for use 
      in patients with rheumatic disease.
CI  - Copyright (c) 2022 by the Journal of Rheumatology.
FAU - Hazlewood, Glen S
AU  - Hazlewood GS
AUID- ORCID: 0000-0001-7709-3741
AD  - G.S. Hazlewood, MD, PhD, Associate Professor, Department of Medicine, and 
      Department of Community Health Sciences, Cumming School of Medicine, University 
      of Calgary, Calgary, Alberta, and Arthritis Research Canada, Richmond, British 
      Columbia, Canada; gshazlew@ucalgary.ca.
FAU - Schieir, Orit
AU  - Schieir O
AUID- ORCID: 0000-0002-5217-9028
AD  - O. Schieir, PhD, Canadian Early Arthritis Cohort Study, Toronto, Ontario, Canada.
FAU - Bykerk, Vivian
AU  - Bykerk V
AUID- ORCID: 0000-0002-1219-3845
AD  - V. Bykerk, MD, Professor, Hospital for Special Surgery, Weill Cornell Medical 
      College, New York, New York, USA.
FAU - Mujaab, Kamso
AU  - Mujaab K
AUID- ORCID: 0000-0003-0436-1850
AD  - K. Mujaab, MSc, P.M. Hull, PGCE PGDip (BJTC), Department of Community Health 
      Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, 
      Canada.
FAU - Tugwell, Peter
AU  - Tugwell P
AD  - P. Tugwell, MD, Professor, Department of Medicine, Faculty of Medicine, 
      University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research 
      Institute, Ottawa, Ontario, Canada.
FAU - Wells, George
AU  - Wells G
AD  - G. Wells, PhD, Professor, Cardiovascular Research Methods Centre, Ottawa Heart 
      Institute and School of Epidemiology and Public Health, University of Ottawa, 
      Ottawa, Ontario, Canada.
FAU - Richards, Dawn
AU  - Richards D
AD  - D. Richards, PhD, L. Proulx, B.Com, Canadian Arthritis Patient Alliance, Toronto, 
      Ontario, Canada.
FAU - Proulx, Laurie
AU  - Proulx L
AUID- ORCID: 0000-0003-1656-0371
AD  - D. Richards, PhD, L. Proulx, B.Com, Canadian Arthritis Patient Alliance, Toronto, 
      Ontario, Canada.
FAU - Hull, Pauline M
AU  - Hull PM
AUID- ORCID: 0000-0002-2954-6811
AD  - K. Mujaab, MSc, P.M. Hull, PGCE PGDip (BJTC), Department of Community Health 
      Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, 
      Canada.
FAU - Bartlett, Susan J
AU  - Bartlett SJ
AUID- ORCID: 0000-0001-9755-2490
AD  - S.J. Bartlett, PhD, Professor, Arthritis Research Canada, Richmond, British 
      Columbia, Department of Medicine, McGill University, and Research 
      Institute-McGill University Health Center, McGill University, Montreal, Quebec, 
      Canada.
LA  - eng
GR  - FRN 156267/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220301
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - VB0R961HZT (Prednisone)
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
CIN - J Rheumatol. 2022 Sep;49(9):967-970. PMID: 35705245
CIN - J Rheumatol. 2022 Sep;49(9):971-973. PMID: 35840147
MH  - Humans
MH  - Prednisone/therapeutic use
MH  - *Arthritis, Rheumatoid/drug therapy
MH  - *Antirheumatic Agents/adverse effects
MH  - Surveys and Questionnaires
MH  - Anti-Inflammatory Agents, Non-Steroidal/adverse effects
OTO - NOTNLM
OT  - adverse effects
OT  - antirheumatic agents
OT  - drug-related side effects and adverse reactions
OT  - patient-reported outcome measures
OT  - rheumatoid arthritis
EDAT- 2022/03/03 06:00
MHDA- 2022/10/26 06:00
CRDT- 2022/03/02 06:11
PHST- 2022/02/09 00:00 [accepted]
PHST- 2022/03/03 06:00 [pubmed]
PHST- 2022/10/26 06:00 [medline]
PHST- 2022/03/02 06:11 [entrez]
AID - jrheum.210688 [pii]
AID - 10.3899/jrheum.210688 [doi]
PST - ppublish
SO  - J Rheumatol. 2022 Sep;49(9):998-1005. doi: 10.3899/jrheum.210688. Epub 2022 Mar 
      1.