PMID- 35233992
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240220
IS  - 2192-6506 (Electronic)
IS  - 2192-6506 (Linking)
VI  - 87
IP  - 3
DP  - 2022 Feb 14
TI  - Smart Drug Delivery Systems Based on DNA Nanotechnology.
PG  - e202100548
LID - 10.1002/cplu.202100548 [doi]
AB  - The development of DNA nanotechnology has attracted tremendous attention in 
      biotechnological and biomedical fields involving biosensing, bioimaging and 
      disease therapy. In particular, precise control over size and shape, easy 
      modification, excellent programmability and inherent homology make the 
      sophisticated DNA nanostructures vital for constructing intelligent drug 
      carriers. Recent advances in the design of multifunctional DNA-based drug 
      delivery systems (DDSs) have demonstrated the effectiveness and advantages of DNA 
      nanostructures, showing the unique benefits and great potential in enhancing the 
      delivery of pharmaceutical compounds and reducing systemic toxicity. This Review 
      aims to overview the latest researches on DNA nanotechnology-enabled nanomedicine 
      and give a perspective on their future opportunities.
CI  - (c) 2022 Wiley-VCH GmbH.
FAU - Fan, Qin
AU  - Fan Q
AD  - Key Laboratory for Organic Electronics & Information Displays (KLOEID), Jiangsu 
      Key Laboratory for Biosensors, Institute of Advanced Materials (IAM) and School 
      of Materials Science and Engineering, Nanjing University of Posts & 
      Telecommunications, Nanjing, 210000, P. R. China.
FAU - He, Zhimei
AU  - He Z
AD  - Smart Health Big Data Analysis and Location Services Engineering Research Center 
      of Jiangsu Province, School of Geographic and Biologic Information, Nanjing 
      University of Posts & Telecommunications, Nanjing, 210000, P. R. China.
FAU - Xiong, Jinxin
AU  - Xiong J
AD  - Key Laboratory for Organic Electronics & Information Displays (KLOEID), Jiangsu 
      Key Laboratory for Biosensors, Institute of Advanced Materials (IAM) and School 
      of Materials Science and Engineering, Nanjing University of Posts & 
      Telecommunications, Nanjing, 210000, P. R. China.
FAU - Chao, Jie
AU  - Chao J
AUID- ORCID: 0000-0003-1030-9944
AD  - Key Laboratory for Organic Electronics & Information Displays (KLOEID), Jiangsu 
      Key Laboratory for Biosensors, Institute of Advanced Materials (IAM) and School 
      of Materials Science and Engineering, Nanjing University of Posts & 
      Telecommunications, Nanjing, 210000, P. R. China.
AD  - Smart Health Big Data Analysis and Location Services Engineering Research Center 
      of Jiangsu Province, School of Geographic and Biologic Information, Nanjing 
      University of Posts & Telecommunications, Nanjing, 210000, P. R. China.
LA  - eng
GR  - 21922408/NSFC/
GR  - 61771253/NSFC/
GR  - BK20190038/Natural Science Foundation of Jiangsu Province for Distinguished Young 
      Scholars/
GR  - BK20212012/Leading-edge Technology Program of Jiangsu Natural Science Foundation/
GR  - 19KJA360007/Key Program of Natural Science Research in Universities of Jiangsu 
      Province/
PT  - Journal Article
PT  - Review
DEP - 20220214
PL  - Germany
TA  - Chempluschem
JT  - ChemPlusChem
JID - 101580948
SB  - IM
OTO - NOTNLM
OT  - DNA nanotechnology
OT  - DNA origami
OT  - drug delivery
OT  - nanomedicine
OT  - therapy
EDAT- 2022/03/03 06:00
MHDA- 2022/03/03 06:01
CRDT- 2022/03/02 06:20
PHST- 2022/02/13 00:00 [revised]
PHST- 2021/12/15 00:00 [received]
PHST- 2022/03/03 06:01 [medline]
PHST- 2022/03/03 06:00 [pubmed]
PHST- 2022/03/02 06:20 [entrez]
AID - 10.1002/cplu.202100548 [doi]
PST - aheadofprint
SO  - Chempluschem. 2022 Feb 14;87(3):e202100548. doi: 10.1002/cplu.202100548.