PMID- 35236020
OWN - NLM
STAT- MEDLINE
DCOM- 20220304
LR  - 20220304
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 429
DP  - 2022 May 5
TI  - Nanocomposites of boronic acid-functionalized magnetic multi-walled carbon 
      nanotubes with flexible branched polymers as a novel desorption/ionization matrix 
      for the capture and direct detection of cis-diol-flavonoid compounds coupled with 
      MALDI-TOF-MS.
PG  - 128055
LID - S0304-3894(21)03024-7 [pii]
LID - 10.1016/j.jhazmat.2021.128055 [doi]
AB  - Novel boronic acid-functionalized magnetic multi-walled carbon nanotubes with 
      flexible branched polymer (Fe(3)O(4)@MWCNTs@epsilon-PL@BA) nanocomposites were 
      fabricated and applied as the desorption/ionization matrix for the MALDI-TOF-MS 
      determination of low molecular weight flavonoids. The prepared nanocomposite was 
      systematically characterized by various techniques. Compared to the traditional 
      organic matrix, the proposed Fe(3)O(4)@MWCNTs@epsilon-PL@BA matrix has excellent 
      ionization efficiency and low-background noise interference due to the MWCNTs 
      unique electron-phonon interaction and the high introduction density of boronic 
      acid functional groups. Good sensitivity and ultra-high salt tolerance of the 
      Fe(3)O(4)@MWCNTs@epsilon-PL@BA-assisted MALDI-TOF-MS were permitted for the 
      determination and quantification of flavonoids in actual samples. Noticeably, the 
      limits of detection (LODs) for the target flavonoids were in the range 17-33 nM. 
      The relative standard deviations (RSDs) of spot-to-spot and sample-to-sample 
      (n = 10) were </= 9.8% and </= 10.1%, respectively. Furthermore, the wide linear 
      ranges (0.1 - 500 microg/mL) and satisfactory calibration plot coefficients (R(2) > 
      0.99) of flavonoids were achieved by MALDI-TOF-MS with the 
      Fe(3)O(4)@MWCNTs@epsilon-PL@BA matrix. Good recoveries (92-105.5%) were achieved for 
      the target flavonoids in practical food samples. Hence, the prepared 
      Fe(3)O(4)@MWCNTs@epsilon-PL@BA nanocomposites have applications in the selective and 
      efficient capture of target flavonoids active biomolecules coupled with 
      MALDI-TOF-MS determination in actual samples.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Li, FuKai
AU  - Li F
AD  - Institute of Quality Standard and Testing Technology for Agro-products, Chinese 
      Academy of Agricultural Sciences (CAAS), Beijing 100081, PR China; Key Laboratory 
      of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, 
      Beijing 100081, PR China.
FAU - Wang, Min
AU  - Wang M
AD  - Institute of Quality Standard and Testing Technology for Agro-products, Chinese 
      Academy of Agricultural Sciences (CAAS), Beijing 100081, PR China; Key Laboratory 
      of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, 
      Beijing 100081, PR China. Electronic address: wangmin@caas.cn.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Institute of Quality Standard and Testing Technology for Agro-products, Chinese 
      Academy of Agricultural Sciences (CAAS), Beijing 100081, PR China; Key Laboratory 
      of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, 
      Beijing 100081, PR China.
FAU - Yang, MengRui
AU  - Yang M
AD  - Institute of Quality Standard and Testing Technology for Agro-products, Chinese 
      Academy of Agricultural Sciences (CAAS), Beijing 100081, PR China; Key Laboratory 
      of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, 
      Beijing 100081, PR China. Electronic address: yangmengrui2014@163.com.
FAU - Wang, TongTong
AU  - Wang T
AD  - Institute of Quality Standard and Testing Technology for Agro-products, Chinese 
      Academy of Agricultural Sciences (CAAS), Beijing 100081, PR China; Key Laboratory 
      of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, 
      Beijing 100081, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211209
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Boronic Acids)
RN  - 0 (Flavonoids)
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Polymers)
SB  - IM
MH  - Boronic Acids
MH  - Flavonoids
MH  - Magnetic Phenomena
MH  - *Nanocomposites
MH  - *Nanotubes, Carbon
MH  - Polymers
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
OTO - NOTNLM
OT  - Boronic acid
OT  - Flavonoids
OT  - MALDI-TOF-MS
OT  - Nanocomposite
OT  - Small biomolecules
EDAT- 2022/03/04 06:00
MHDA- 2022/03/05 06:00
CRDT- 2022/03/03 01:00
PHST- 2021/09/16 00:00 [received]
PHST- 2021/11/18 00:00 [revised]
PHST- 2021/12/07 00:00 [accepted]
PHST- 2022/03/03 01:00 [entrez]
PHST- 2022/03/04 06:00 [pubmed]
PHST- 2022/03/05 06:00 [medline]
AID - S0304-3894(21)03024-7 [pii]
AID - 10.1016/j.jhazmat.2021.128055 [doi]
PST - ppublish
SO  - J Hazard Mater. 2022 May 5;429:128055. doi: 10.1016/j.jhazmat.2021.128055. Epub 
      2021 Dec 9.