PMID- 35237232
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220502
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 13
DP  - 2022
TI  - Erythrocyte Indices in Creutzfeldt-Jakob Disease Predict Survival Time.
PG  - 839081
LID - 10.3389/fneur.2022.839081 [doi]
LID - 839081
AB  - BACKGROUND: Creutzfeldt-Jakob disease (CJD) is a devastating neurodegenerative 
      disease caused by propagation of abnormally folded prion proteins (PrP(Sc)). Some 
      fluid biomarkers have been reported to be associated with disease duration in 
      CJD. Based on studies which have found that prion protein (PrP(C)) played a role 
      in erythrocytic hematopoiesis, we evaluated the association between peripheral 
      red blood cell indices and survival time in CJD. METHODS: We retrospectively 
      collected data on peripheral red blood cell indices, including red blood cell 
      (RBC) count, hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), 
      mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration 
      (MCHC), and red cell distribution width (RDW), from 125 CJD patients. Cox 
      proportional hazard models were generated to determine whether red cell indices 
      correlated with survival time of patients with CJD. RESULTS: Of the 125 included 
      participants, 70 (56%) were male, and the mean age at diagnosis (SD) was 60.3 
      (9.5) years. Hemoglobin levels (hazard ratio 1.710, 95% CI 1.124-2.600, p = 
      0.012) and HCT (hazard ratio 1.689, 95% CI 1.112-2.565, p=0.014) were 
      significantly associated with survival time after controlling for sex, age, and 
      Barthel Index. Red blood cell count, MCV, MCH, MCHC, and RDW were not associated 
      with survival time before or after adjusting for covariates. CONCLUSIONS: Our 
      study found that Hb and HCT were significantly associated with survival time in 
      patients with CJD. These results may inform evaluation of the mechanisms of 
      interaction between prion disease and hematopoiesis, and indicate that Hb and HCT 
      may be potential prognostic biomarkers.
CI  - Copyright (c) 2022 Kong, Chen, Zhang and Wu.
FAU - Kong, Yu
AU  - Kong Y
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
FAU - Chen, Zhongyun
AU  - Chen Z
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
FAU - Zhang, Jing
AU  - Zhang J
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
FAU - Wu, Liyong
AU  - Wu L
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220214
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC8884143
OTO - NOTNLM
OT  - Creutzfeldt-Jakob disease
OT  - erythrocyte indices
OT  - hematocrit
OT  - hemoglobin
OT  - red cell indices
OT  - survival time
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/04 06:00
MHDA- 2022/03/04 06:01
PMCR- 2022/02/14
CRDT- 2022/03/03 05:34
PHST- 2021/12/19 00:00 [received]
PHST- 2022/01/21 00:00 [accepted]
PHST- 2022/03/03 05:34 [entrez]
PHST- 2022/03/04 06:00 [pubmed]
PHST- 2022/03/04 06:01 [medline]
PHST- 2022/02/14 00:00 [pmc-release]
AID - 10.3389/fneur.2022.839081 [doi]
PST - epublish
SO  - Front Neurol. 2022 Feb 14;13:839081. doi: 10.3389/fneur.2022.839081. eCollection 
      2022.