PMID- 35238614
OWN - NLM
STAT- MEDLINE
DCOM- 20220610
LR  - 20220616
IS  - 2768-3613 (Electronic)
IS  - 2768-3605 (Linking)
VI  - 28
IP  - 6
DP  - 2022 Jun
TI  - Therapeutic Phlebotomy in Patients with Grade 1 Hypertension: A 
      Randomized-Controlled Trial.
PG  - 530-539
LID - 10.1089/jicm.2021.0396 [doi]
AB  - Aim: Study aim was to investigate the effects of therapeutic phlebotomy on 
      ambulatory blood pressure in patients with grade 1 hypertension. Methods: In this 
      randomized-controlled intervention study, patients with unmedicated hypertension 
      grade 1 were randomized into an intervention group (phlebotomy group; 500 mL 
      bloodletting at baseline and after 6 weeks) and a control group (waiting list) 
      and followed up for 8 weeks. Primary endpoint was the 24-h ambulatory mean 
      arterial pressure between the intervention and control groups after 8 weeks. 
      Secondary outcome parameters included ambulatory/resting systolic/diastolic blood 
      pressure, heart rate, and selected laboratory parameters (e.g., hemoglobin, 
      hematocrit, erythrocytes, and ferritin). Resting systolic/diastolic blood 
      pressure/heart rate and blood count were also assessed at 6 weeks before the 
      second phlebotomy to ensure safety. A per-protocol analysis was performed. 
      Results: Fifty-three hypertension participants (56.7 +/- 10.5 years) were included 
      in the analysis (n = 25 intervention group, n = 28 control group). The ambulatory 
      measured mean arterial pressure decreased by -1.12 +/- 5.16 mmHg in the 
      intervention group and increased by 0.43 +/- 3.82 mmHg in the control group 
      (between-group difference: -1.55 +/- 4.46, p = 0.22). Hemoglobin, hematocrit, 
      erythrocytes, and ferritin showed more pronounced reductions in the intervention 
      group in comparison with the control group, with significant between-group 
      differences. Subgroup analysis showed trends regarding the effects on different 
      groups classified by serum ferritin concentration, body mass index, age, and sex. 
      Two adverse events (AEs) (anemia and dizziness) occurred in association with the 
      phlebotomy, but no serious AEs. Conclusions: Study results showed that 
      therapeutic phlebotomy resulted in only minimal reductions of 24-h ambulatory 
      blood pressure measurement values in patients with unmedicated grade 1 
      hypertension. Further high-quality clinical studies are warranted, as this 
      finding contradicts the results of other studies.
FAU - Jeitler, Michael
AU  - Jeitler M
AUID- ORCID: 0000-0003-3277-9090
AD  - Institute of Social Medicine, Epidemiology and Health Economics, 
      Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin 
      and Humboldt-Universitaat zu Berlin, Berlin, Germany.
AD  - Department of Internal and Integrative Medicine, Immanuel Hospital Berlin, 
      Berlin, Germany.
FAU - Roth, Sandra
AU  - Roth S
AD  - Institute of Social Medicine, Epidemiology and Health Economics, 
      Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin 
      and Humboldt-Universitaat zu Berlin, Berlin, Germany.
FAU - Steckhan, Nico
AU  - Steckhan N
AD  - Institute of Social Medicine, Epidemiology and Health Economics, 
      Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin 
      and Humboldt-Universitaat zu Berlin, Berlin, Germany.
AD  - Hasso Plattner Institute, Digital Health Center, University of Potsdam, Potsdam, 
      Germany.
FAU - Meier, Larissa
AU  - Meier L
AD  - Institute of Social Medicine, Epidemiology and Health Economics, 
      Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin 
      and Humboldt-Universitaat zu Berlin, Berlin, Germany.
FAU - Koppold-Liebscher, Daniela A
AU  - Koppold-Liebscher DA
AUID- ORCID: 0000-0003-3367-3327
AD  - Institute of Social Medicine, Epidemiology and Health Economics, 
      Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin 
      and Humboldt-Universitaat zu Berlin, Berlin, Germany.
AD  - Department of Internal and Integrative Medicine, Immanuel Hospital Berlin, 
      Berlin, Germany.
FAU - Kandil, Farid I
AU  - Kandil FI
AD  - Institute of Social Medicine, Epidemiology and Health Economics, 
      Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin 
      and Humboldt-Universitaat zu Berlin, Berlin, Germany.
FAU - Ostermann, Thomas
AU  - Ostermann T
AUID- ORCID: 0000-0003-2695-0701
AD  - Department of Psychology and Psychotherapy, Witten/Herdecke University, Witten, 
      Germany.
FAU - Stange, Rainer
AU  - Stange R
AD  - Institute of Social Medicine, Epidemiology and Health Economics, 
      Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin 
      and Humboldt-Universitaat zu Berlin, Berlin, Germany.
AD  - Department of Internal and Integrative Medicine, Immanuel Hospital Berlin, 
      Berlin, Germany.
FAU - Kessler, Christian S
AU  - Kessler CS
AUID- ORCID: 0000-0001-7794-8375
AD  - Institute of Social Medicine, Epidemiology and Health Economics, 
      Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin 
      and Humboldt-Universitaat zu Berlin, Berlin, Germany.
AD  - Department of Internal and Integrative Medicine, Immanuel Hospital Berlin, 
      Berlin, Germany.
FAU - Brinkhaus, Benno
AU  - Brinkhaus B
AD  - Institute of Social Medicine, Epidemiology and Health Economics, 
      Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin 
      and Humboldt-Universitaat zu Berlin, Berlin, Germany.
FAU - Michalsen, Andreas
AU  - Michalsen A
AD  - Institute of Social Medicine, Epidemiology and Health Economics, 
      Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin 
      and Humboldt-Universitaat zu Berlin, Berlin, Germany.
AD  - Department of Internal and Integrative Medicine, Immanuel Hospital Berlin, 
      Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220302
PL  - United States
TA  - J Integr Complement Med
JT  - Journal of integrative and complementary medicine
JID - 9918283075806676
SB  - IM
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Humans
MH  - *Hypertension/blood/pathology/therapy
MH  - *Phlebotomy
OTO - NOTNLM
OT  - bloodletting
OT  - complementary medicine
OT  - hypertension
OT  - phlebotomy
EDAT- 2022/03/04 06:00
MHDA- 2022/06/11 06:00
CRDT- 2022/03/03 12:16
PHST- 2022/03/04 06:00 [pubmed]
PHST- 2022/06/11 06:00 [medline]
PHST- 2022/03/03 12:16 [entrez]
AID - 10.1089/jicm.2021.0396 [doi]
PST - ppublish
SO  - J Integr Complement Med. 2022 Jun;28(6):530-539. doi: 10.1089/jicm.2021.0396. 
      Epub 2022 Mar 2.