PMID- 35239096
OWN - NLM
STAT- MEDLINE
DCOM- 20220609
LR  - 20220823
IS  - 1128-045X (Electronic)
IS  - 1123-6337 (Linking)
VI  - 26
IP  - 7
DP  - 2022 Jul
TI  - The impact of bowel dysfunction on health-related quality of life after rectal 
      cancer surgery: a systematic review.
PG  - 515-527
LID - 10.1007/s10151-022-02594-0 [doi]
AB  - BACKGROUND: Symptoms of bowel dysfunction after sphincter-preserving rectal 
      cancer surgery have an important impact on health-related quality of life 
      (HRQOL), but that relationship is complex. A better understanding of this 
      relationship allows for better informed shared decision-making about surgery. Our 
      objective was to perform a systematic review to determine which HRQOL domains are 
      most affected by postoperative bowel dysfunction. METHODS: A systematic review of 
      the CINAHL, Cochrane Library, Embase, Medline, PsycInfo, PubMed, Web of Science, 
      and Scopus databases was performed according to Preferred Reporting Items for 
      Systematic Reviews and Meta-Analyses guidelines. We included studies that 
      evaluated bowel function after sphincter-preserving rectal cancer surgery and 
      assessed HRQOL using a validated instrument. The quality of HRQOL analysis was 
      assessed using an 11-item checklist. The main outcome was the impact bowel 
      dysfunction had on global and domain specific quality-of-life indices. The impact 
      was evaluated for clinical relevance using the Minimum Clinical Important 
      Difference (MCID) for each specific HRQOL instrument. RESULTS: Out of 952 unique 
      citations, 103 studies were full-text reviews. Eighteen studies met the inclusion 
      criteria (4 prospective cohorts and 9 cross-sectional studies). Of the 15 studies 
      with long-term follow-up, the time to assessment after surgery ranged from 1.2 to 
      14.6 years. The low anterior resection syndrome score and European Organization 
      for Research and Treatment core quality-of-life questionnaire (EORTC QLQ-C30) 
      were the most commonly used instruments. Medium and large magnitudes in MCID were 
      seen for global health, social functioning, emotional functioning, fatigue, 
      diarrhea, and financial difficulties. Among included studies, the most 
      consistently reported functional domains affected by bowel function were social 
      functioning and emotional functioning. CONCLUSIONS: Following 
      sphincter-preserving rectal cancer surgery, poor bowel function mainly affects 
      the social and emotional functional domains of HRQOL, which in turn impact global 
      scores. This finding can help inform patients about expected changes in HRQOL 
      after rectal cancer surgery and facilitate individualized treatment decisions.
CI  - (c) 2022. Springer Nature Switzerland AG.
FAU - Al Rashid, F
AU  - Al Rashid F
AUID- ORCID: 0000-0002-1243-2228
AD  - Department of Surgery, McGill University Health Centre, 1001 boulevard Decarie 
      DS1-3310, Montreal, QC, H4A 3J1, Canada. F.alrashid@gmail.com.
FAU - Liberman, A S
AU  - Liberman AS
AD  - Department of Surgery, McGill University Health Centre, 1001 boulevard Decarie 
      DS1-3310, Montreal, QC, H4A 3J1, Canada.
FAU - Charlebois, P
AU  - Charlebois P
AD  - Department of Surgery, McGill University Health Centre, 1001 boulevard Decarie 
      DS1-3310, Montreal, QC, H4A 3J1, Canada.
FAU - Stein, B
AU  - Stein B
AD  - Department of Surgery, McGill University Health Centre, 1001 boulevard Decarie 
      DS1-3310, Montreal, QC, H4A 3J1, Canada.
FAU - Feldman, L S
AU  - Feldman LS
AD  - Steinberg-Bernstein Centre for Minimally Invasive Surgery and Innovation, McGill 
      University Health Centre, Montreal, QC, Canada.
FAU - Fiore, J F Jr
AU  - Fiore JF Jr
AD  - Steinberg-Bernstein Centre for Minimally Invasive Surgery and Innovation, McGill 
      University Health Centre, Montreal, QC, Canada.
FAU - Lee, L
AU  - Lee L
AD  - Department of Surgery, McGill University Health Centre, 1001 boulevard Decarie 
      DS1-3310, Montreal, QC, H4A 3J1, Canada.
AD  - Steinberg-Bernstein Centre for Minimally Invasive Surgery and Innovation, McGill 
      University Health Centre, Montreal, QC, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20220303
PL  - Italy
TA  - Tech Coloproctol
JT  - Techniques in coloproctology
JID - 9613614
SB  - IM
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Postoperative Complications/etiology
MH  - Prospective Studies
MH  - *Quality of Life
MH  - *Rectal Neoplasms/surgery
MH  - Surveys and Questionnaires
MH  - Syndrome
OTO - NOTNLM
OT  - Bowel dysfunction
OT  - Health-related quality of life
OT  - Low anterior resection syndrome
OT  - Postoperative outcomes
OT  - Rectal cancer
EDAT- 2022/03/04 06:00
MHDA- 2022/06/10 06:00
CRDT- 2022/03/03 12:19
PHST- 2021/06/13 00:00 [received]
PHST- 2022/02/04 00:00 [accepted]
PHST- 2022/03/04 06:00 [pubmed]
PHST- 2022/06/10 06:00 [medline]
PHST- 2022/03/03 12:19 [entrez]
AID - 10.1007/s10151-022-02594-0 [pii]
AID - 10.1007/s10151-022-02594-0 [doi]
PST - ppublish
SO  - Tech Coloproctol. 2022 Jul;26(7):515-527. doi: 10.1007/s10151-022-02594-0. Epub 
      2022 Mar 3.