PMID- 35241287
OWN - NLM
STAT- MEDLINE
DCOM- 20220919
LR  - 20220922
IS  - 1875-595X (Electronic)
IS  - 0020-6539 (Print)
IS  - 0020-6539 (Linking)
VI  - 72
IP  - 5
DP  - 2022 Oct
TI  - Functional Impairment and Periodontitis in Rheumatoid Arthritis.
PG  - 641-647
LID - S0020-6539(22)00022-3 [pii]
LID - 10.1016/j.identj.2022.01.002 [doi]
AB  - BACKGROUND: This study explored the association of functional impairment due to 
      rheumatoid arthritis (RA) and RA disease activity with periodontal disease in 
      patients with RA. METHODS: Ninety-three patients with RA were included. Their RA 
      functional status was assessed using the Steinbrocker classification. The serum 
      level of matrix metalloproteinase-3 (MMP-3) was used as an indicator of RA 
      disease activity. Probing depth (PD) and clinical attachment level (CAL) were 
      used as indicators of periodontal status. We examined the association of RA 
      severity and MMP-3 levels with periodontal status using a generalised linear 
      model (GLM). RESULTS: In a multivariate GLM, the coefficient for the mean PD was 
      significantly positive in those with RA severity classes III or IV (reference: 
      class I; beta = 0.14; 95% confidence interval [CI], 0.03-0.25; P = .02) independent 
      of other confounding variables. In multivariate GLM using the mean CAL as the 
      dependent variable, the coefficient was significant in patients with high MMP-3 
      levels (10 ng/mL; beta = 0.005; 95% CI, 0.001-0.008; P = .02). CONCLUSIONS: 
      Functional impairment due to RA may affect PD, and high serum levels of MMP-3 may 
      affect CAL.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Hashimoto, Hiroko
AU  - Hashimoto H
AD  - Department of Preventive Dentistry and Dental Public Health, School of Dentistry, 
      Aichi Gakuin University, Nagoya, Japan.
FAU - Hashimoto, Shimpei
AU  - Hashimoto S
AD  - Hashimoto Orthopedic Surgery Clinic, Nagoya, Japan.
FAU - Shimazaki, Yoshihiro
AU  - Shimazaki Y
AD  - Department of Preventive Dentistry and Dental Public Health, School of Dentistry, 
      Aichi Gakuin University, Nagoya, Japan. Electronic address: shima@dpc.agu.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20220228
PL  - England
TA  - Int Dent J
JT  - International dental journal
JID - 0374714
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - *Arthritis, Rheumatoid/complications
MH  - Humans
MH  - Matrix Metalloproteinase 3
MH  - Periodontal Index
MH  - *Periodontitis/complications
PMC - PMC9485534
OTO - NOTNLM
OT  - Epidemiology
OT  - Functional impairment
OT  - Periodontitis
OT  - Rheumatoid arthritis
OT  - Serum MMP-3
COIS- Conflict of interest None disclosed.
EDAT- 2022/03/05 06:00
MHDA- 2022/09/20 06:00
PMCR- 2022/02/28
CRDT- 2022/03/04 05:35
PHST- 2021/10/22 00:00 [received]
PHST- 2022/01/18 00:00 [revised]
PHST- 2022/01/19 00:00 [accepted]
PHST- 2022/03/05 06:00 [pubmed]
PHST- 2022/09/20 06:00 [medline]
PHST- 2022/03/04 05:35 [entrez]
PHST- 2022/02/28 00:00 [pmc-release]
AID - S0020-6539(22)00022-3 [pii]
AID - 10.1016/j.identj.2022.01.002 [doi]
PST - ppublish
SO  - Int Dent J. 2022 Oct;72(5):641-647. doi: 10.1016/j.identj.2022.01.002. Epub 2022 
      Feb 28.