PMID- 35242141
OWN - NLM
STAT- MEDLINE
DCOM- 20220502
LR  - 20220502
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - ​Circulating Cytokines in Myocardial Infarction Are Associated With Coronary 
      Blood Flow.
PG  - 837642
LID - 10.3389/fimmu.2022.837642 [doi]
LID - 837642
AB  - BACKGROUND: The level of systemic inflammation correlates with the severity of 
      the clinical course of acute myocardial infarction (AMI). It has been shown that 
      circulating cytokines and endothelial dysfunction play an important role in the 
      process of clot formation. The aim of our study was to assess the concentration 
      of various circulating cytokines, endothelial function and blood clotting in AMI 
      patients depending on the blood flow through the infarction-related artery (IRA). 
      METHODS: We included 75 patients with AMI. 58 presented with ST-elevation 
      myocardial infarction (STEMI) and 17 had non-ST-elevation myocardial infarction 
      (non-STEMI). A flow-mediated dilation test (FMD test), thrombodynamics and 
      rotational thromboelastometry as well as assessment of 14 serum cytokines using 
      xMAP technology were performed. FINDINGS: Non-STEMI-patients were characterized 
      by higher levels of MDC, MIP-1beta, TNF-alpha. Moreover, we observed that patients with 
      impaired blood flow through the IRA (TIMI flow 0-1) had higher average and 
      initial clot growth rates, earlier onset of spontaneous clots, C-reactive protein 
      (CRP) and IL-10 compared to patients with preserved blood flow through the IRA 
      (TIMI flow 2-3). Patients with TIMI 2-3 blood flow had higher level of IP-10. 
      IL-10 correlated with CRP and pro-inflammatory cytokines levels, initial clot 
      growth rate and clot lysis time in TIMI 0-1 patients. All these differences were 
      statistically significant. INTERPRETATION: We demonstrated that concentrations of 
      the inflammatory cytokines correlate not only with the form of myocardial 
      infarction (STEMI or non-STEMI), but also with the blood flow through the 
      infarct-related artery. Inflammatory response, functional state of endothelium, 
      and clot formation are closely linked with each other. A combination of these 
      parameters affects the patency of the infarct-related artery.
CI  - Copyright (c) 2022 Kalinskaya, Dukhin, Lebedeva, Maryukhnich, Rusakovich, 
      Vorobyeva, Shpektor, Margolis and Vasilieva.
FAU - Kalinskaya, Anna
AU  - Kalinskaya A
AD  - Laboratory of Atherothrombosis, Cardiology Department, Moscow State University of 
      Medicine and Dentistry, Moscow, Russia.
AD  - Clinical City Hospital named after I.V. Davydovsky, Moscow Department of 
      Healthcare, Moscow, Russia.
FAU - Dukhin, Oleg
AU  - Dukhin O
AD  - Laboratory of Atherothrombosis, Cardiology Department, Moscow State University of 
      Medicine and Dentistry, Moscow, Russia.
AD  - Clinical City Hospital named after I.V. Davydovsky, Moscow Department of 
      Healthcare, Moscow, Russia.
FAU - Lebedeva, Anna
AU  - Lebedeva A
AD  - Laboratory of Atherothrombosis, Cardiology Department, Moscow State University of 
      Medicine and Dentistry, Moscow, Russia.
FAU - Maryukhnich, Elena
AU  - Maryukhnich E
AD  - Laboratory of Atherothrombosis, Cardiology Department, Moscow State University of 
      Medicine and Dentistry, Moscow, Russia.
FAU - Rusakovich, Georgy
AU  - Rusakovich G
AD  - Laboratory of Atherothrombosis, Cardiology Department, Moscow State University of 
      Medicine and Dentistry, Moscow, Russia.
FAU - Vorobyeva, Daria
AU  - Vorobyeva D
AD  - Laboratory of Atherothrombosis, Cardiology Department, Moscow State University of 
      Medicine and Dentistry, Moscow, Russia.
FAU - Shpektor, Alexander
AU  - Shpektor A
AD  - Laboratory of Atherothrombosis, Cardiology Department, Moscow State University of 
      Medicine and Dentistry, Moscow, Russia.
AD  - Clinical City Hospital named after I.V. Davydovsky, Moscow Department of 
      Healthcare, Moscow, Russia.
FAU - Margolis, Leonid
AU  - Margolis L
AD  - Eunice Kennedy Shriver National Institute of Child Health and Human Development, 
      National Institutes of Health, Bethesda, MD, United States.
FAU - Vasilieva, Elena
AU  - Vasilieva E
AD  - Laboratory of Atherothrombosis, Cardiology Department, Moscow State University of 
      Medicine and Dentistry, Moscow, Russia.
AD  - Clinical City Hospital named after I.V. Davydovsky, Moscow Department of 
      Healthcare, Moscow, Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220215
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Cytokines)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Cytokines
MH  - Humans
MH  - Infarction
MH  - Interleukin-10
MH  - *Myocardial Infarction
MH  - *Non-ST Elevated Myocardial Infarction
MH  - *ST Elevation Myocardial Infarction
PMC - PMC8886043
OTO - NOTNLM
OT  - *clot formation
OT  - *cytokines
OT  - *endothelium
OT  - *inflammation
OT  - *myocardial infarction
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/05 06:00
MHDA- 2022/05/03 06:00
PMCR- 2022/02/15
CRDT- 2022/03/04 05:40
PHST- 2021/12/16 00:00 [received]
PHST- 2022/01/21 00:00 [accepted]
PHST- 2022/03/04 05:40 [entrez]
PHST- 2022/03/05 06:00 [pubmed]
PHST- 2022/05/03 06:00 [medline]
PHST- 2022/02/15 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.837642 [doi]
PST - epublish
SO  - Front Immunol. 2022 Feb 15;13:837642. doi: 10.3389/fimmu.2022.837642. eCollection 
      2022.