PMID- 35242808
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220502
IS  - 2296-875X (Print)
IS  - 2296-875X (Electronic)
IS  - 2296-875X (Linking)
VI  - 9
DP  - 2022
TI  - Major Risk Factors Analysis of Pruritus Complicated by Type 2 Diabetes Mellitus 
      and the Effect of Comprehensive Nursing Intervention.
PG  - 842884
LID - 10.3389/fsurg.2022.842884 [doi]
LID - 842884
AB  - OBJECTIVE: To observe the main risk factors for pruritic skin evidence 
      complicating type 2 diabetes mellitus (T2DM) and the effectiveness of 
      interventions with comprehensive care measures. METHODS: Two hundred and twenty 
      four patients with T2DM admitted to our hospital from June 2020 to November 2021 
      were selected and divided into Diabetic pruritus group (DP group, n = 71) and 
      T2DM group (n = 153) according to the patients' complications of pruritus. 
      General information such as gender, age, body mass index (BMI), duration of 
      illness, family history, treatment modalities, other comorbidities, underlying 
      illnesses were collected from all patients. Fasting plasma glucose (FPG), renal 
      function [Serum creatinine (Scr), urea nitrogen (BUN), uric acid (BUA)], lipid 
      levels [total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein 
      cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)] were measured 
      in all patients on day 2 after admission. Risk factors for pruritus complicating 
      T2DM were identified by single multifactorial analysis. Meanwhile, patients in 
      the DP group were divided into group A (n = 35) and group B (n = 36) using the 
      random number table method. Group A adopted the conventional care mode and group 
      B patients adopted the comprehensive care interventions to compare the care 
      effects [visual analog score (VAS) before and after care, treatment efficiency, 
      care satisfaction rate] of patients in groups A and B; the levels of pruritus 
      mediator indicators [substance P,beta-endorphin (beta-EP) and gamma-interferon (INF-gamma)] 
      before and after care. RESULTS: Risk factors for pruritus in T2DM were age, 
      duration of DM, combined Diabetic peripheral neuropathy (DPN), combined diabetic 
      retinopathy (DR), combined diabetic kidney disease (DKD) and serum FPG levels (P 
      <0.05). Satisfaction rate of nursing care, treatment efficiency, post-care 
      improvement in VAS scores, serum substance P, beta-EP and INF-gamma levels and other 
      mediators of pruritus were better in Group B with integrated nursing intervention 
      than in group A with conventional care only (P < 0.05). CONCLUSION: Pruritus in 
      T2DM is associated with age, duration of DM, combined DPN, combined DR, combined 
      DKD and FPG levels. Comprehensive care according to the above risk factors can 
      effectively relieve patients' clinical symptoms and signs, improve the level of 
      pruritus mediators and patient-care relationship.
CI  - Copyright (c) 2022 Yang, Chen, Li and Xu.
FAU - Yang, Qiu Ping
AU  - Yang QP
AD  - Endocrinology Ward, Shenzhen Traditional Chinese Medicine Hospital (The Fourth 
      Clinical Medical School of Guangzhou University of Chinese Medicine), Shenzhen, 
      China.
FAU - Chen, Yuan Yuan
AU  - Chen YY
AD  - Nursing Department, Shenzhen Traditional Chinese Medicine Hospital (The Fourth 
      Clinical Medical School of Guangzhou University of Chinese Medicine), Shenzhen, 
      China.
FAU - Li, Zhenzhen
AU  - Li Z
AD  - Surgery Ward 3-4, Shenzhen Traditional Chinese Medicine Hospital (The Fourth 
      Clinical Medical School of Guangzhou University of Chinese Medicine), Shenzhen, 
      China.
FAU - Xu, Mingming
AU  - Xu M
AD  - Nursing Department, Shenzhen Traditional Chinese Medicine Hospital (The Fourth 
      Clinical Medical School of Guangzhou University of Chinese Medicine), Shenzhen, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220215
PL  - Switzerland
TA  - Front Surg
JT  - Frontiers in surgery
JID - 101645127
PMC - PMC8887712
OTO - NOTNLM
OT  - comprehensive care
OT  - pruritic medium
OT  - pruritus
OT  - risk factors
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/05 06:00
MHDA- 2022/03/05 06:01
PMCR- 2022/02/15
CRDT- 2022/03/04 05:42
PHST- 2021/12/24 00:00 [received]
PHST- 2022/01/17 00:00 [accepted]
PHST- 2022/03/04 05:42 [entrez]
PHST- 2022/03/05 06:00 [pubmed]
PHST- 2022/03/05 06:01 [medline]
PHST- 2022/02/15 00:00 [pmc-release]
AID - 10.3389/fsurg.2022.842884 [doi]
PST - epublish
SO  - Front Surg. 2022 Feb 15;9:842884. doi: 10.3389/fsurg.2022.842884. eCollection 
      2022.