PMID- 35243868
OWN - NLM
STAT- MEDLINE
DCOM- 20220826
LR  - 20220826
IS  - 1699-5198 (Electronic)
IS  - 0212-1611 (Linking)
VI  - 39
IP  - 4
DP  - 2022 Aug 25
TI  - Effects of very low-carbohydrate ketogenic diet on lipid metabolism in patients 
      with type II diabetes mellitus: a meta-analysis.
PG  - 916-923
LID - 10.20960/nh.03987 [doi]
AB  - Objective: to evaluate the lipid metabolism of patients with type 2 diabetes 
      mellitus (T2DM) after very low-carbohydrate ketogenic (VLCK) diet treatment, so 
      as to provide an evidence-based basis for better dietary management and 
      comprehensive treatment of diabetic patients. Methods: PubMed, Cochrane Library, 
      Embase, and Web of Science databases were searched for randomized controlled 
      trial about VLCK diet on lipid metabolism of T2DM up to September 2021. The data 
      were analyzed using the Stata 15.0; standardized mean difference (SMD) was used 
      as effect size. Results: ten articles were included in this meta-analysis. There 
      were no significant differences between the two groups in total cholesterol (SMD 
      = -0.07, 95 % CI: -0.06-0.20, p > 0.05), HDL (SMD = 0.13, 95 % CI: -0.05-0.31, p 
      > 0.05) and LDL (SMD = 0.07, 95 % CI: -0.06-0.20, p > 0.05) levels after 
      treatment. No difference was found in total cholesterol, HDL, and LDL levels 
      between the two groups after 3, 6, and 12 months of treatment (p > 0.05). 
      Triglyceride levels decreased after VLCK diet compared with control (SMD = -0.49, 
      95 % CI: -0.82 to -0.17, p = 0.003). A marked reduction of triglyceride levels 
      was identified after 3 months of VLCK diet treatment (SMD = -0.69, 95 % CI: -1.00 
      to -0.38), without significant difference after 6 and 12 months. Conclusion: T2DM 
      patients who receive a VLCK diet to lower blood glucose are not associated with 
      increased levels of total cholesterol and LDL, and decreased levels of HDL. 
      Additionally, this diet can achieve a short-term reduction of triglyceride 
      levels.
FAU - Li, Meijuan
AU  - Li M
AD  - Department of Endocrinology. The First Affiliated Hospital Zhejiang University 
      School of Medicine.
FAU - Yuan, Jingyun
AU  - Yuan J
AD  - Department of Endocrinology. The First Affiliated Hospital Zhejiang University 
      School of Medicine.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
TT  - Efectos de la dieta cetogenica muy baja en carbohidratos sobre el metabolismo de 
      los lipidos en pacientes con diabetes mellitus de tipo II: un metaanalisis.
PL  - Spain
TA  - Nutr Hosp
JT  - Nutricion hospitalaria
JID - 9100365
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Blood Glucose/analysis
MH  - Cholesterol
MH  - *Diabetes Mellitus, Type 2
MH  - *Diet, Ketogenic
MH  - Humans
MH  - Lipid Metabolism
MH  - Lipids
MH  - Triglycerides
OTO - NOTNLM
OT  - Dieta cetogenica muy baja en carbohidratos. VLCK. Diabetes mellitus. 
      Trigliceridos. Metaanalisis.
EDAT- 2022/03/05 06:00
MHDA- 2022/08/27 06:00
CRDT- 2022/03/04 08:43
PHST- 2022/03/05 06:00 [pubmed]
PHST- 2022/08/27 06:00 [medline]
PHST- 2022/03/04 08:43 [entrez]
AID - 10.20960/nh.03987 [doi]
PST - ppublish
SO  - Nutr Hosp. 2022 Aug 25;39(4):916-923. doi: 10.20960/nh.03987.