PMID- 35245549 OWN - NLM STAT- MEDLINE DCOM- 20221223 LR - 20221223 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 827 DP - 2022 Jun 25 TI - Persistent organic pollutant exposures among Greenlandic adults in relation to lifestyle and diet: New data from the ACCEPT cohort. PG - 154270 LID - S0048-9697(22)01362-6 [pii] LID - 10.1016/j.scitotenv.2022.154270 [doi] AB - High concentrations of persistent organic pollutants (POPs) in blood of the Greenlandic population are well known. The exposure is mainly through traditional food intake, including marine mammals and seabirds. The present study aimed to follow up on POP concentrations (organochlorine pesticides, polychlorinated biphenyls, per- and polyfluoroalkyl substances, and halogenated flame retardants (HFRs)) and relations to lifestyle and diet of the mothers included in the Greenlandic ACCEPT cohort (3-5 years after inclusion in 2013-15) and to include the children's fathers. This new data collection in 2019-20 included blood samples for measurement of POP concentrations and lifestyle and food frequency questionnaires from 101 mothers and 76 fathers aged 24-55 years living in Nuuk, Sisimiut, and Ilulissat, Greenland. The mothers' intra-individual median percentage decrease in POP concentrations from inclusion to this follow-up (3-5 years later) was 16-58%, except for mirex (0% change). Median concentrations of POPs were 1.4-4.6 times higher in fathers than in mothers. The POPs differed by residential town with generally higher concentrations in Ilulissat compared to Sisimiut and Nuuk. We report, for the first time, novel HFRs in human samples from Greenland. However, concentrations were low and only dechlorane plus (with its anti-isomer) was detected in >50% of the samples. Most POPs correlated positively with age and n-3/n-6 fatty acid ratio. The lipophilic POPs correlated positively with the percentage of life lived in Greenland, whereas few POPs correlated positively with BMI, income (personal and household), education, and alcohol intake. The POPs generally associated positively with the intake of marine mammals, seabirds, and dried fish, while few POPs associated positively with Greenlandic fish intake. In contrast, POPs generally associated negatively with imported meat products intake. The study findings may be of interest for future dietary recommendations in Greenland. We discuss the potential explanations for the findings and suggestions for future research. CI - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Wielsoe, Maria AU - Wielsoe M AD - Centre for Arctic Health & Molecular Epidemiology, Department of Public Health, Aarhus University, Bartholins Alle 2, 8000 Aarhus, Denmark. Electronic address: mwielsoe@ph.au.dk. FAU - Long, Manhai AU - Long M AD - Centre for Arctic Health & Molecular Epidemiology, Department of Public Health, Aarhus University, Bartholins Alle 2, 8000 Aarhus, Denmark. FAU - Bossi, Rossana AU - Bossi R AD - Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark. FAU - Vorkamp, Katrin AU - Vorkamp K AD - Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark. FAU - Bonefeld-Jorgensen, Eva Cecilie AU - Bonefeld-Jorgensen EC AD - Centre for Arctic Health & Molecular Epidemiology, Department of Public Health, Aarhus University, Bartholins Alle 2, 8000 Aarhus, Denmark; Greenland Centre for Health Research, University of Greenland, Manutooq 1, 3905 Nuussuaq, Greenland. Electronic address: ebj@ph.au.dk. LA - eng PT - Journal Article DEP - 20220301 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Environmental Pollutants) RN - 0 (Halogenated Diphenyl Ethers) RN - 0 (Persistent Organic Pollutants) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Animals MH - Humans MH - Diet MH - *Environmental Pollutants/analysis MH - Halogenated Diphenyl Ethers MH - Life Style MH - Mammals MH - Persistent Organic Pollutants MH - *Polychlorinated Biphenyls OTO - NOTNLM OT - Arctic OT - Halogenated flame retardants (HFRs) OT - Organochlorine pesticides OT - Per- and polyfluoroalkyl substances (PFAS) OT - Polybrominated diphenyl ethers (PBDEs) OT - Polychlorinated biphenyls (PCBs) COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/03/05 06:00 MHDA- 2022/05/11 06:00 CRDT- 2022/03/04 20:09 PHST- 2021/12/17 00:00 [received] PHST- 2022/02/20 00:00 [revised] PHST- 2022/02/27 00:00 [accepted] PHST- 2022/03/05 06:00 [pubmed] PHST- 2022/05/11 06:00 [medline] PHST- 2022/03/04 20:09 [entrez] AID - S0048-9697(22)01362-6 [pii] AID - 10.1016/j.scitotenv.2022.154270 [doi] PST - ppublish SO - Sci Total Environ. 2022 Jun 25;827:154270. doi: 10.1016/j.scitotenv.2022.154270. Epub 2022 Mar 1.