PMID- 35246117 OWN - NLM STAT- MEDLINE DCOM- 20220308 LR - 20220531 IS - 1472-6963 (Electronic) IS - 1472-6963 (Linking) VI - 22 IP - 1 DP - 2022 Mar 4 TI - Establishing and evaluating physician-pharmacist collaborative clinics to manage patients with type 2 diabetes in primary hospitals in Hunan province: study protocol of a multi-site randomized controlled trial in the era of COVID-19 pandemic. PG - 299 LID - 10.1186/s12913-022-07653-8 [doi] LID - 299 AB - BACKGROUND: The COVID-19 pandemic has exerted an unprecedented and universal impact on global health system, resulting in noticeable challenges in traditional chronic disease care, of which diabetes was reported to be most influenced by the reduction in healthcare resources in the pandemic. China has the world's largest diabetes population, and current diabetes management in China is unsatisfactory, particularly in rural areas. Studies in developed countries have demonstrated that physician-pharmacist collaborative clinics are efficient and cost-effective for diabetes management, but little is known if this mode could be adapted in primary hospitals in China. The aim of this proposed study is to develop and evaluate physician-pharmacist collaborative clinics to manage type 2 diabetes mellitus (T2DM) in primary hospitals in Hunan province. METHODS: A multi-site randomized controlled trial will be conducted to evaluate the effectiveness and cost-effectiveness of the physician-pharmacist collaborative clinics compared with usual care for Chinese patients with T2DM. Six primary hospitals will participate in the study, which will recruit 600 eligible patients. Patients in the intervention group will receive services from both physicians and pharmacists in the collaborative clinics, while the control group will receive usual care from physicians. Patients will be followed up at the 3rd, 6th, 9th and 12th month. Comparison between the two groups will be conducted by assessing the clinical parameters, process indicators and costs on diabetes. A satisfaction survey will also be carried out at the end of the study. DISCUSSION: If effective, the physician-pharmacist collaborative clinics can be adapted and used in primary hospitals of China to improve glycemic control, enhance medication adherence, decrease incidence of complications and reduce patients' dependence on physicians. Findings from the present study are meaningful for developing evidence-based diabetes care policy in rural China, especially in the COVID-19 pandemic era. TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2000031839 , Registered 12 April 2020. CI - (c) 2022. The Author(s). FAU - Tan, Sheng-Lan AU - Tan SL AD - Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. AD - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. FAU - Xiao, Jie AU - Xiao J AD - Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. AD - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. FAU - Yuan, Hai-Yan AU - Yuan HY AD - Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. AD - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. FAU - Chen, Lei AU - Chen L AD - Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. AD - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. FAU - Wang, Qing AU - Wang Q AD - Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. AD - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. FAU - Xiang, Da-Xiong AU - Xiang DX AD - Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. AD - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. FAU - Li, Xia AU - Li X AD - Department of Endocrine, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. FAU - Zhou, Yan-Gang AU - Zhou YG AD - Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. AD - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. FAU - Guo, Yan AU - Guo Y AD - Department of Pharmacy, Taoyuan People's Hospital, Changde, 415700, China. FAU - Huang, Hai-Ying AU - Huang HY AD - Department of Pharmacy, The People's Hospital of Liuyang, Changsha, 410300, China. FAU - Zhao, Dan-Hui AU - Zhao DH AD - Department of Pharmacy, The First People's Hospital of Pingjiang, Yueyang, 410400, China. FAU - Li, Yue AU - Li Y AD - Department of Pharmacy, People's Hospital of Ningxiang, Changsha, 410600, China. FAU - Wang, Li AU - Wang L AD - Department of Pharmacy, Yueyang Central Hospital, Yueyang, 414020, China. FAU - Li, Qun AU - Li Q AD - Department of Pharmacy, The Second People's Hospital of Huaihua, Huaihua, 418000, China. FAU - Liu, Juan AU - Liu J AD - Department of Pharmacy, Yiyang Central Hospital, Yiyang, 413000, China. FAU - Xu, Ping AU - Xu P AUID- ORCID: 0000-0001-8692-0219 AD - Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. xuping1109@csu.edu.cn. AD - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. xuping1109@csu.edu.cn. LA - eng GR - 18-292/China Medical Board/ GR - 2019158/Hunan Provincial Health Commission/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20220304 PL - England TA - BMC Health Serv Res JT - BMC health services research JID - 101088677 SB - IM MH - *COVID-19/epidemiology MH - China/epidemiology MH - *Diabetes Mellitus, Type 2/drug therapy/epidemiology MH - Hospitals MH - Humans MH - *Interprofessional Relations MH - Multicenter Studies as Topic MH - Pandemics MH - *Pharmacists MH - *Physicians MH - Randomized Controlled Trials as Topic PMC - PMC8894569 OTO - NOTNLM OT - Collaborative clinics OT - Diabetes OT - Pharmacist OT - RCT OT - Rural area COIS- The authors declare that they have no competing interests. EDAT- 2022/03/06 06:00 MHDA- 2022/03/09 06:00 PMCR- 2022/03/04 CRDT- 2022/03/05 05:25 PHST- 2022/01/24 00:00 [received] PHST- 2022/02/18 00:00 [accepted] PHST- 2022/03/05 05:25 [entrez] PHST- 2022/03/06 06:00 [pubmed] PHST- 2022/03/09 06:00 [medline] PHST- 2022/03/04 00:00 [pmc-release] AID - 10.1186/s12913-022-07653-8 [pii] AID - 7653 [pii] AID - 10.1186/s12913-022-07653-8 [doi] PST - epublish SO - BMC Health Serv Res. 2022 Mar 4;22(1):299. doi: 10.1186/s12913-022-07653-8.