PMID- 35246529
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 2058-7716 (Print)
IS  - 2058-7716 (Electronic)
IS  - 2058-7716 (Linking)
VI  - 8
IP  - 1
DP  - 2022 Mar 4
TI  - Osteopontin aggravates acute lung injury in influenza virus infection by 
      promoting macrophages necroptosis.
PG  - 97
LID - 10.1038/s41420-022-00904-x [doi]
LID - 97
AB  - Infection with influenza A virus (IAV) can trigger pulmonary inflammation and 
      lung damage. Osteopontin (OPN) is an essential regulator of cell death and 
      immunity. However, the role and underlying mechanism of OPN in cell death in 
      IAV-induced pulmonary injury remain poorly understood. Here, we demonstrated that 
      OPN-deficient (OPN(-/-)) mice were insensitive to IAV, exhibiting decreased viral 
      loads and attenuated lung injury after IAV infection compared to those in 
      wild-type (WT) mice. Moreover, macrophage necroptosis was significantly reduced 
      in OPN(-/-) mice infected with IAV compared to that in infected WT mice. OPN 
      increased the expression of necroptosis-related genes and exacerbated macrophage 
      necroptosis in IAV-infected THP1 cells. Notably, adoptive transfer of WT bone 
      marrow-derived macrophages (BMDMs) or OPN(-/-) BMDMs into mice restored 
      resistance to influenza infection, and the rescue effect of OPN(-/-) BMDMs was 
      better than that of WT BMDMs. Collectively, these results suggest that OPN 
      deficiency in macrophages reduces necroptosis, which leads to a decrease in viral 
      titers and protects against IAV infection. Therefore, OPN is a potential target 
      for the treatment of IAV infection.
CI  - (c) 2022. The Author(s).
FAU - Wang, Jinping
AU  - Wang J
AD  - School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 
      Wenzhou, China.
FAU - Li, Xuehui
AU  - Li X
AD  - State Key Laboratory for Diagnosis & Treatment of Infectious Diseases, National 
      Clinical Research Center for Infectious Disease, Collaborative Innovation Center 
      for Diagnosis & Treatment of Infectious Diseases, The First Affiliated Hospital, 
      College of Medicine, Zhejiang University, Hangzhou, China.
FAU - Wang, Yuchong
AU  - Wang Y
AD  - State Key Laboratory for Diagnosis & Treatment of Infectious Diseases, National 
      Clinical Research Center for Infectious Disease, Collaborative Innovation Center 
      for Diagnosis & Treatment of Infectious Diseases, The First Affiliated Hospital, 
      College of Medicine, Zhejiang University, Hangzhou, China.
FAU - Li, Yuyu
AU  - Li Y
AD  - State Key Laboratory for Diagnosis & Treatment of Infectious Diseases, National 
      Clinical Research Center for Infectious Disease, Collaborative Innovation Center 
      for Diagnosis & Treatment of Infectious Diseases, The First Affiliated Hospital, 
      College of Medicine, Zhejiang University, Hangzhou, China.
FAU - Shi, Fan
AU  - Shi F
AD  - State Key Laboratory for Diagnosis & Treatment of Infectious Diseases, National 
      Clinical Research Center for Infectious Disease, Collaborative Innovation Center 
      for Diagnosis & Treatment of Infectious Diseases, The First Affiliated Hospital, 
      College of Medicine, Zhejiang University, Hangzhou, China.
FAU - Diao, Hongyan
AU  - Diao H
AUID- ORCID: 0000-0002-7197-4051
AD  - School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 
      Wenzhou, China. diaohy@zju.edu.cn.
AD  - State Key Laboratory for Diagnosis & Treatment of Infectious Diseases, National 
      Clinical Research Center for Infectious Disease, Collaborative Innovation Center 
      for Diagnosis & Treatment of Infectious Diseases, The First Affiliated Hospital, 
      College of Medicine, Zhejiang University, Hangzhou, China. diaohy@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220304
PL  - United States
TA  - Cell Death Discov
JT  - Cell death discovery
JID - 101665035
PMC - PMC8897470
COIS- The authors declare no competing interests.
EDAT- 2022/03/06 06:00
MHDA- 2022/03/06 06:01
PMCR- 2022/03/04
CRDT- 2022/03/05 05:28
PHST- 2021/11/12 00:00 [received]
PHST- 2022/02/14 00:00 [accepted]
PHST- 2022/01/26 00:00 [revised]
PHST- 2022/03/05 05:28 [entrez]
PHST- 2022/03/06 06:00 [pubmed]
PHST- 2022/03/06 06:01 [medline]
PHST- 2022/03/04 00:00 [pmc-release]
AID - 10.1038/s41420-022-00904-x [pii]
AID - 904 [pii]
AID - 10.1038/s41420-022-00904-x [doi]
PST - epublish
SO  - Cell Death Discov. 2022 Mar 4;8(1):97. doi: 10.1038/s41420-022-00904-x.