PMID- 35246806
OWN - NLM
STAT- MEDLINE
DCOM- 20220330
LR  - 20220727
IS  - 1976-3794 (Electronic)
IS  - 1225-8873 (Linking)
VI  - 60
IP  - 4
DP  - 2022 Apr
TI  - Gut microbiota metabolic characteristics in coronary artery disease patients with 
      hyperhomocysteine.
PG  - 419-428
LID - 10.1007/s12275-022-1451-2 [doi]
AB  - Hyperhomocysteine (HHcy) is known as a risk factor for coronary artery disease 
      (CAD). Despite the knowledge that gut microbiota related metabolism pathway 
      shares metabolites with that of Hcy, little has been shown concerning the 
      association between HHcy and gut microbiota. To explore their relationship in the 
      context of CAD, 105 patients and 14 healthy controls were recruited from one 
      single medical center located in Beijing, China. Their serum and fecal samples 
      were collected, with multi-omics analyses performed via LC/MS/MS and 16S rRNA 
      gene V3-V4 region sequencing, respectively. Participants from the prospective 
      cohort were divided into CAD, CAD & HHcy and healthy controls (HC) groups based 
      on the diagnosis and serum Hcy concentration. The results revealed significant 
      different metabolic signatures between CAD and CAD & HHcy groups. CAD patients 
      with HHcy suffered a heavier atherosclerotic burden compared to CAD patients, and 
      the difference was closely associated to betaine-homocysteine S-methyltransferase 
      (BHMT)-related metabolites and trimethylamine N-oxide (TMAO)-related metabolites. 
      Dimethylglycine (DMG) exhibited a strong positive correlation with serum total 
      Hcy (tHcy), and TMAO and trimethylysine (TML) were associated with heavier 
      atherosclerotic burden. Multiple other metabolites were also identified to be 
      related to distinct cardiovascular risk factors. Additionally, Clostridium 
      cluster IV and Butyricimonas were enriched in CAD patients with elevated tHcy. 
      Our study suggested that CAD patients with elevated tHcy were correlated with 
      higher atherosclerotic burden, and the impaired Hcy metabolism and cardiovascular 
      risk were closely associated with BHMT-related metabolites, TMAO-related 
      metabolites and impaired gut microbiota homeostasis.
CI  - (c) 2022. The Microbiological Society of Korea.
FAU - Tian, Ran
AU  - Tian R
AD  - Department of Cardiology, Peking Union Medical College Hospital, Beijing, 100730, 
      P. R. China.
FAU - Liu, Hong-Hong
AU  - Liu HH
AD  - Department of Cardiology, Peking Union Medical College Hospital, Beijing, 100730, 
      P. R. China.
FAU - Feng, Si-Qin
AU  - Feng SQ
AD  - Department of Cardiology, Peking Union Medical College Hospital, Beijing, 100730, 
      P. R. China.
FAU - Wang, Yi-Fei
AU  - Wang YF
AD  - School of Medicine, Tsinghua University, Beijing, 100084, P. R. China.
AD  - Department of Cardiology, Beijing Tsinghua Changgung Hospital, Tsinghua 
      University, Beijing, 102218, P. R. China.
FAU - Wang, Yi-Yang
AU  - Wang YY
AD  - School of Medicine, Tsinghua University, Beijing, 100084, P. R. China.
FAU - Chen, Yu-Xiong
AU  - Chen YX
AD  - Department of Cardiology, Peking Union Medical College Hospital, Beijing, 100730, 
      P. R. China.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Cardiology, Peking Union Medical College Hospital, Beijing, 100730, 
      P. R. China.
FAU - Zhang, Shu-Yang
AU  - Zhang SY
AD  - Department of Cardiology, Peking Union Medical College Hospital, Beijing, 100730, 
      P. R. China. shuyangzhang103@nrdrs.org.
LA  - eng
PT  - Journal Article
DEP - 20220304
PL  - Korea (South)
TA  - J Microbiol
JT  - Journal of microbiology (Seoul, Korea)
JID - 9703165
RN  - 0 (RNA, Ribosomal, 16S)
SB  - IM
MH  - *Coronary Artery Disease
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - Prospective Studies
MH  - RNA, Ribosomal, 16S/genetics
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - coronary artery disease
OT  - gut microbiota
OT  - hyperhomocysteine
OT  - trimethylamine n-oxide
OT  - trimethylysine
EDAT- 2022/03/06 06:00
MHDA- 2022/03/31 06:00
CRDT- 2022/03/05 05:31
PHST- 2021/08/30 00:00 [received]
PHST- 2021/12/23 00:00 [accepted]
PHST- 2021/12/13 00:00 [revised]
PHST- 2022/03/06 06:00 [pubmed]
PHST- 2022/03/31 06:00 [medline]
PHST- 2022/03/05 05:31 [entrez]
AID - 10.1007/s12275-022-1451-2 [pii]
AID - 10.1007/s12275-022-1451-2 [doi]
PST - ppublish
SO  - J Microbiol. 2022 Apr;60(4):419-428. doi: 10.1007/s12275-022-1451-2. Epub 2022 
      Mar 4.