PMID- 35247483
OWN - NLM
STAT- MEDLINE
DCOM- 20220420
LR  - 20220420
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 305
DP  - 2022 May 15
TI  - Determinants of family functioning in caregivers of persons with 
      obsessive-compulsive disorder.
PG  - 179-187
LID - S0165-0327(22)00214-2 [pii]
LID - 10.1016/j.jad.2022.02.065 [doi]
AB  - BACKGROUND: Obsessive-compulsive disorder (OCD) is known to cause significant 
      burden to patients and their caregivers. However, there is limited data on its 
      impact on family functioning, especially from families with an adult member 
      having OCD. METHODS: Four hundred subjects, which included treatment-seeking 
      adult OCD patients (n = 200) and their caregivers (n = 200) were recruited. 
      Patients were evaluated using the Mini International Neuropsychiatric Interview 
      (MINI) and the Yale-Brown Obsessive-Compulsive Scale (YBOCS). Caregivers were 
      evaluated using the MINI, the Caregiver Strain Index (CSI), the Hamilton Anxiety 
      Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), the 
      Socio-Occupational Functioning Assessment Scale (SOFAS), the Family Accommodation 
      Scale (FAS) and the Connor-David Resilience scale (CD-RISC) in a cross-sectional 
      interview. Family functioning was measured using the OCD Family Functioning (OFF) 
      Scale. Structural equation modeling (SEM) was carried out to evaluate the 
      relationships between the patient and caregiver variables to predict family 
      functioning. RESULTS: From the best-fitting path model, we ascertained that OCD 
      symptoms did not have a direct relationship with family dysfunction. Their 
      effects were in turn was mediated by family accommodation, anxiety, caregiver 
      stress/burden and depression. "Contamination & washing" was the only significant 
      symptom dimension within the model. Caregiver resilience was found to predict 
      only their individual functioning, and not family functioning. LIMITATIONS: Study 
      sample included patients from a tertiary care OCD service, only one caregiver 
      from each patient's family was interviewed. CONCLUSIONS: Evaluating family 
      functioning, addressing it as part of interventional modules for patients and 
      caregivers may help improving treatment outcomes.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Murthy, Nithyananda S
AU  - Murthy NS
AD  - OCD Clinic, National Institute of Mental Health & Neuro-Sciences (NIMHANS), 
      Bangalore, India; Department of Psychiatric Social Work, NIMHANS, Bangalore, 
      India.
FAU - Balachander, Srinivas
AU  - Balachander S
AD  - OCD Clinic, National Institute of Mental Health & Neuro-Sciences (NIMHANS), 
      Bangalore, India; Department of Psychiatry, NIMHANS, Bangalore, India.
FAU - Nirmala, B P
AU  - Nirmala BP
AD  - Department of Psychiatric Social Work, NIMHANS, Bangalore, India.
FAU - Pandian, R Dhanasekara
AU  - Pandian RD
AD  - Department of Psychiatric Social Work, NIMHANS, Bangalore, India.
FAU - Cherian, Anish V
AU  - Cherian AV
AD  - OCD Clinic, National Institute of Mental Health & Neuro-Sciences (NIMHANS), 
      Bangalore, India; Department of Psychiatric Social Work, NIMHANS, Bangalore, 
      India.
FAU - Arumugham, Shyam Sundar
AU  - Arumugham SS
AD  - OCD Clinic, National Institute of Mental Health & Neuro-Sciences (NIMHANS), 
      Bangalore, India; Department of Psychiatry, NIMHANS, Bangalore, India.
FAU - Reddy, Y C Janardhan
AU  - Reddy YCJ
AD  - OCD Clinic, National Institute of Mental Health & Neuro-Sciences (NIMHANS), 
      Bangalore, India; Department of Psychiatry, NIMHANS, Bangalore, India. Electronic 
      address: ycjreddy@gmail.com.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220303
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Anxiety/psychology
MH  - Anxiety Disorders
MH  - *Caregivers/psychology
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Obsessive-Compulsive Disorder/psychology
OTO - NOTNLM
OT  - Accommodation
OT  - Burden
OT  - Caregivers
OT  - Family functioning
OT  - OCD
EDAT- 2022/03/06 06:00
MHDA- 2022/04/21 06:00
CRDT- 2022/03/05 20:12
PHST- 2021/11/24 00:00 [received]
PHST- 2022/01/16 00:00 [revised]
PHST- 2022/02/22 00:00 [accepted]
PHST- 2022/03/06 06:00 [pubmed]
PHST- 2022/04/21 06:00 [medline]
PHST- 2022/03/05 20:12 [entrez]
AID - S0165-0327(22)00214-2 [pii]
AID - 10.1016/j.jad.2022.02.065 [doi]
PST - ppublish
SO  - J Affect Disord. 2022 May 15;305:179-187. doi: 10.1016/j.jad.2022.02.065. Epub 
      2022 Mar 3.