PMID- 35247789
OWN - NLM
STAT- MEDLINE
DCOM- 20220603
LR  - 20220603
IS  - 1532-3072 (Electronic)
IS  - 0040-8166 (Linking)
VI  - 76
DP  - 2022 Jun
TI  - The melatonin MT(2) receptor is involved in the anti-apoptotic effects of 
      melatonin in rats with type 2 diabetes mellitus.
PG  - 101763
LID - S0040-8166(22)00035-0 [pii]
LID - 10.1016/j.tice.2022.101763 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a widely prevalent chronic disease and risk 
      factor for several other diseases, such as cardiovascular diseases, neuropathy, 
      nephropathy, and retinopathy. Apoptosis is a homeostatic mechanism to maintain 
      cell numbers at a certain level in tissues. Chronic high blood glucose levels 
      might lead to mitochondrial dysfunction and trigger undesirable apoptosis in 
      T2DM. The pineal hormone melatonin has been shown to regulate apoptosis. The aim 
      of this study was to investigate the impact of the melatonin MT(2) receptor in 
      the role of melatonin to prevent undesirable apotosis in different tissues of 
      diabetic rats. Male Sprague Dawley rats were randomly divided into 4 groups; 1. 
      Control group (only vehicle), 2. Diabetic group (streptozotozin/nicotinamide 
      treated), 3. Diabetic group treated with melatonin (500mug/kg/day), and 4. 
      Diabetic group treated with melatonin (500 mug/kg/day for 6 weeks) and the 
      selective MT(2) receptor antagonist luzindole (0.25 g/kg/day for 6 weeks). 
      Various tissue samples (kidney, liver, adipose tissue, pancreas) were removed 
      after 6 weeks for immunohistochemistry and western blot analysis. Our results 
      demonstrated an increased rate of apoptosis in different tissues of diabetic rats 
      compared to controls with melatonin reducing the apoptotic rate in the tissues of 
      rats with T2DM. Furthermore, the anti-apoptotic effects of melatonin were partly 
      mediated by the melatonin MT(2) receptor.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Yapislar, Hande
AU  - Yapislar H
AD  - Acibadem University, School of Medicine, Department of Physiology, 34684, 
      Istanbul, Turkey. Electronic address: handeyapislar@gmail.com.
FAU - Haciosmanoglu, Ebru
AU  - Haciosmanoglu E
AD  - Faculty of Medicine, Department of Biophysics, Bezmialem Vakif University, 
      Istanbul, Turkey.
FAU - Sarioglu, Turkan
AU  - Sarioglu T
AD  - Department of Histology and Embryology, Fundamental Sciences, Faculty of 
      Dentistry, Istanbul Kent University Istanbul, Turkey.
FAU - Ekmekcioglu, Cem
AU  - Ekmekcioglu C
AD  - Department of Environmental Health, Center for Public Health, Medical University 
      of Vienna, 1090, Vienna, Austria.
LA  - eng
PT  - Journal Article
DEP - 20220222
PL  - Scotland
TA  - Tissue Cell
JT  - Tissue & cell
JID - 0214745
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Adipose Tissue
MH  - Animals
MH  - *Diabetes Mellitus, Experimental/drug therapy
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Male
MH  - *Melatonin/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Apoptosis
OT  - Experimental diabetes mellitus
OT  - Luzindole
OT  - MT(2)
OT  - Melatonin
OT  - T2DM
EDAT- 2022/03/06 06:00
MHDA- 2022/06/07 06:00
CRDT- 2022/03/05 20:16
PHST- 2021/09/23 00:00 [received]
PHST- 2022/02/10 00:00 [revised]
PHST- 2022/02/18 00:00 [accepted]
PHST- 2022/03/06 06:00 [pubmed]
PHST- 2022/06/07 06:00 [medline]
PHST- 2022/03/05 20:16 [entrez]
AID - S0040-8166(22)00035-0 [pii]
AID - 10.1016/j.tice.2022.101763 [doi]
PST - ppublish
SO  - Tissue Cell. 2022 Jun;76:101763. doi: 10.1016/j.tice.2022.101763. Epub 2022 Feb 
      22.