PMID- 35247819
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220407
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 243
DP  - 2022 Jun 1
TI  - Covalent organic framework-based solid phase microextraction coupled with 
      electrospray ionization mass spectrometry for sensitive screening and 
      quantitative evaluation of carbamazepine and its metabolite in mice.
PG  - 123341
LID - S0039-9140(22)00137-0 [pii]
LID - 10.1016/j.talanta.2022.123341 [doi]
AB  - Carbamazepine (CBZ) and its metabolite carbamazepine-10,11-epoxide (CBZEP) play 
      vital role in the treatment of epilepsy. It is of great importance to develop a 
      method for rapid and sensitive monitoring of CBZ and CBZEP due to their narrow 
      therapeutic index. Herein, an imine-linked-based covalent organic framework was 
      synthesized by using 1,3,5-tris (4-aminophenyl) benzene (TPB) and 
      1,3,5-triformylbenzene (TFB) (denoted as TPB-TFB-COF)，and applied as a 
      solid-phase microextraction (SPME) probe for extracting CBZ and CBZEP. The 
      TPB-TFB-COF showed large surface areas (371 m(2) g(-1)), high regular porosity 
      (1.23 nm) and extraordinary stability, which rendered it an ideal adsorbent for 
      highly efficient enrichment of CBZ and CBZEP. Accordingly, an attractive strategy 
      of the combination of the TPB-TFB-COF-based SPME probe and electrospray 
      ionization mass spectrometry system (ESI/MS) was proposed for rapid screening and 
      sensitive monitoring of CBZ and CBZEP. Under the optimized parameters, the 
      developed method exhibited good linearity for CBZ and CBZEP in the range of 
      4-1000 mug L(-1) with correlation coefficient (r) no less than 0.9953, and the 
      corresponding limits of detection (LODs) were 0.4 and 2.5 mug L(-1), respectively. 
      Moreover, high enrichment factors (EFs, 202-351 folds) and satisfactory relative 
      standard deviations (RSDs) of one probe (3.3-5.1%) and probe-to-probe (4.8-5.6%) 
      were obtained. By using the proposed method, sensitive screening and quantitative 
      evaluation of CBZ and CBZEP in mice whole blood and tissue homogenates were 
      successfully achieved, indicating the promising applicability of the 
      TPB-TFB-COF-SPME-AMIS as a powerful tool for drug monitoring.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Huang, Weini
AU  - Huang W
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, 
      China.
FAU - Shao, Wenya
AU  - Shao W
AD  - Department of Preventive Medicine, School of Public Health, Fujian Medical 
      University, Fuzhou, 350122, China.
FAU - Ji, Yin
AU  - Ji Y
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, 
      China.
FAU - Li, Heming
AU  - Li H
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, 
      China.
FAU - Chen, Jiajing
AU  - Chen J
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, 
      China.
FAU - Lin, Zian
AU  - Lin Z
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, 
      China. Electronic address: zianlin@fzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220301
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Metal-Organic Frameworks)
RN  - 33CM23913M (Carbamazepine)
SB  - IM
MH  - Animals
MH  - Carbamazepine
MH  - Limit of Detection
MH  - *Metal-Organic Frameworks/chemistry
MH  - Mice
MH  - *Solid Phase Microextraction/methods
MH  - Spectrometry, Mass, Electrospray Ionization
OTO - NOTNLM
OT  - Carbamazepine
OT  - Carbamazepine-10,11-epoxide
OT  - Covalent organic frameworks
OT  - Electrospray ionization mass spectrometry
OT  - Mice
OT  - Solid phase microextraction
EDAT- 2022/03/06 06:00
MHDA- 2022/04/08 06:00
CRDT- 2022/03/05 20:17
PHST- 2021/12/21 00:00 [received]
PHST- 2022/02/24 00:00 [revised]
PHST- 2022/02/28 00:00 [accepted]
PHST- 2022/03/06 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
PHST- 2022/03/05 20:17 [entrez]
AID - S0039-9140(22)00137-0 [pii]
AID - 10.1016/j.talanta.2022.123341 [doi]
PST - ppublish
SO  - Talanta. 2022 Jun 1;243:123341. doi: 10.1016/j.talanta.2022.123341. Epub 2022 Mar 
      1.