PMID- 35247838
OWN - NLM
STAT- MEDLINE
DCOM- 20220415
LR  - 20221202
IS  - 1876-7753 (Electronic)
IS  - 1873-5061 (Linking)
VI  - 60
DP  - 2022 Apr
TI  - Generation of human induced pluripotent stem cell (iPSC) lines derived from five 
      patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and 
      three non-carrier family members.
PG  - 102737
LID - S1873-5061(22)00086-1 [pii]
LID - 10.1016/j.scr.2022.102737 [doi]
AB  - The R14del pathogenic variant in the phospholamban (PLN) gene (PLN-R14del), has 
      been identified in families with hereditary cardiomyopathy, including dilated and 
      arrhythmogenic cardiomyopathies. Here we have generated human iPSC lines from 
      five PLN-R14del carriers and three non-carrier family members. Peripheral blood 
      mononuclear cells (PBMC) were obtained from the eight individuals and 
      reprogrammed using Sendai viral vector system carrying the Yamanaka factors. All 
      eight lines show typical iPSC morphology, normal karyotype, high expression of 
      pluripotency markers, and possess the ability to differentiate into all three 
      germ layers. These lines represent valuable resources for studying the 
      pathophysiological mechanisms of PLN-R14del associated cardiomyopathy.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Mittal, Nishka
AU  - Mittal N
AD  - Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New 
      York, NY, USA.
FAU - Dave, Jaydev
AU  - Dave J
AD  - Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New 
      York, NY, USA.
FAU - Harakalova, Magdalena
AU  - Harakalova M
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands; Regenerative Medicine Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - van Tintelen, J Peter
AU  - van Tintelen JP
AD  - Department of Genetics, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - Asselbergs, Folkert W
AU  - Asselbergs FW
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - Doevendans, Pieter A
AU  - Doevendans PA
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands; Netherlands Heart Foundation, Utrecht, The Netherlands.
FAU - Costa, Kevin D
AU  - Costa KD
AD  - Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New 
      York, NY, USA.
FAU - Turnbull, Irene C
AU  - Turnbull IC
AD  - Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New 
      York, NY, USA.
FAU - Stillitano, Francesca
AU  - Stillitano F
AD  - Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New 
      York, NY, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220301
PL  - England
TA  - Stem Cell Res
JT  - Stem cell research
JID - 101316957
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (phospholamban)
SB  - IM
MH  - Calcium-Binding Proteins/genetics
MH  - *Cardiomyopathies/metabolism
MH  - Humans
MH  - *Induced Pluripotent Stem Cells/metabolism
MH  - Leukocytes, Mononuclear/metabolism
MH  - Mutation
EDAT- 2022/03/06 06:00
MHDA- 2022/04/16 06:00
CRDT- 2022/03/05 20:18
PHST- 2022/02/09 00:00 [received]
PHST- 2022/02/20 00:00 [revised]
PHST- 2022/02/26 00:00 [accepted]
PHST- 2022/03/06 06:00 [pubmed]
PHST- 2022/04/16 06:00 [medline]
PHST- 2022/03/05 20:18 [entrez]
AID - S1873-5061(22)00086-1 [pii]
AID - 10.1016/j.scr.2022.102737 [doi]
PST - ppublish
SO  - Stem Cell Res. 2022 Apr;60:102737. doi: 10.1016/j.scr.2022.102737. Epub 2022 Mar 
      1.