PMID- 35248457
OWN - NLM
STAT- MEDLINE
DCOM- 20220524
LR  - 20230602
IS  - 1879-1972 (Electronic)
IS  - 1054-139X (Print)
IS  - 1054-139X (Linking)
VI  - 70
IP  - 6
DP  - 2022 Jun
TI  - Longitudinal Evidence of a Vicious Cycle Between Nucleus Accumbens Microstructure 
      and Childhood Weight Gain.
PG  - 961-969
LID - S1054-139X(22)00002-7 [pii]
LID - 10.1016/j.jadohealth.2022.01.002 [doi]
AB  - PURPOSE: Pediatric obesity is a growing public health concern. Previous work has 
      observed diet to impact nucleus accumbens (NAcc) inflammation in rodents, 
      measured by the reactive proliferation of glial cells. Recent work in humans has 
      demonstrated a relationship between NAcc cell density-a proxy for 
      neuroinflammation-and weight gain in youth; however, the directionality of this 
      relationship in the developing brain and association with diet remains unknown. 
      METHODS: Waist circumference (WC) and NAcc cell density were collected in a large 
      cohort of children (n > 2,000) participating in the Adolescent Brain Cognitive 
      Development (ABCD) Study (release 3.0) at baseline (9-10 y) and at a Year 2 
      follow-up (11-12 y). Latent change score modeling (LCSM) was used to disentangle 
      contributions of baseline measures to two-year changes in WC percentile and NAcc 
      cellularity. In addition, the role of NAcc cellularity in mediating the 
      relationship between diet and WC percentile was assessed using dietary intake 
      data collected at Year 2. RESULTS: LCSM indicates that baseline WC percentile 
      influences change in NAcc cellularity and that baseline NAcc cell density 
      influences change in WC percentile. NAcc cellularity was significantly associated 
      with WC percentile at Year 2 and mediated the relationship between dietary fat 
      consumption and WC percentile. CONCLUSIONS: These results implicate a vicious 
      cycle whereby NAcc cell density biases longitudinal changes in WC percentile and 
      vice versa. Moreover, NAcc cell density may mediate the relationship between diet 
      and weight gain in youth. These findings suggest that diet-induced inflammation 
      of reward circuitry may lead to behavioral changes that further contribute to 
      weight gain.
CI  - Copyright (c) 2022 Society for Adolescent Health and Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Rapuano, Kristina M
AU  - Rapuano KM
AD  - Department of Psychology, Yale University, New Haven, Connecticut. Electronic 
      address: kristina.rapuano@yale.edu.
FAU - Berrian, Nia
AU  - Berrian N
AD  - Department of Psychology, Yale University, New Haven, Connecticut.
FAU - Baskin-Sommers, Arielle
AU  - Baskin-Sommers A
AD  - Department of Psychology, Yale University, New Haven, Connecticut.
FAU - Decarie-Spain, Lea
AU  - Decarie-Spain L
AD  - Department of Biological Sciences, University of Southern California, Los 
      Angeles, California.
FAU - Sharma, Sandeep
AU  - Sharma S
AD  - Department of Comparative Biology and Experimental Medicine, University of 
      Calgary, Calgary, Alberta, Canada.
FAU - Fulton, Stephanie
AU  - Fulton S
AD  - Department of Nutrition, University of Montreal & Centre de Recherche du CHUM, 
      Montreal, Quebec, Canada.
FAU - Casey, B J
AU  - Casey BJ
AD  - Department of Psychology, Yale University, New Haven, Connecticut.
FAU - Watts, Richard
AU  - Watts R
AD  - Department of Psychology, Yale University, New Haven, Connecticut.
LA  - eng
GR  - U24 DA041147/DA/NIDA NIH HHS/United States
GR  - U01 DA051039/DA/NIDA NIH HHS/United States
GR  - U01 DA041120/DA/NIDA NIH HHS/United States
GR  - U01 DA051018/DA/NIDA NIH HHS/United States
GR  - U24 DA041123/DA/NIDA NIH HHS/United States
GR  - U01 DA051038/DA/NIDA NIH HHS/United States
GR  - U01 DA051037/DA/NIDA NIH HHS/United States
GR  - U01 DA051016/DA/NIDA NIH HHS/United States
GR  - U01 DA041106/DA/NIDA NIH HHS/United States
GR  - U01 DA041117/DA/NIDA NIH HHS/United States
GR  - U01 DA041148/DA/NIDA NIH HHS/United States
GR  - U01 DA041174/DA/NIDA NIH HHS/United States
GR  - U01 DA041093/DA/NIDA NIH HHS/United States
GR  - R01 DK097399/DK/NIDDK NIH HHS/United States
GR  - U01 DA041134/DA/NIDA NIH HHS/United States
GR  - U01 DA041022/DA/NIDA NIH HHS/United States
GR  - U01 DA041156/DA/NIDA NIH HHS/United States
GR  - U01 DA050987/DA/NIDA NIH HHS/United States
GR  - U01 DA041025/DA/NIDA NIH HHS/United States
GR  - U01 DA050989/DA/NIDA NIH HHS/United States
GR  - U01 DA041089/DA/NIDA NIH HHS/United States
GR  - U01 DA050988/DA/NIDA NIH HHS/United States
GR  - U01 DA041028/DA/NIDA NIH HHS/United States
GR  - U01 DA041048/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20220302
PL  - United States
TA  - J Adolesc Health
JT  - The Journal of adolescent health : official publication of the Society for 
      Adolescent Medicine
JID - 9102136
SB  - IM
MH  - Adolescent
MH  - Body Mass Index
MH  - Child
MH  - Humans
MH  - Inflammation
MH  - *Nucleus Accumbens
MH  - *Pediatric Obesity
MH  - Waist Circumference
MH  - Weight Gain
PMC - PMC9133207
MID - NIHMS1785681
OTO - NOTNLM
OT  - Adolescent health
OT  - Diet
OT  - Neuroinflammation
OT  - Nucleus accumbens
OT  - Pediatric obesity
OT  - Restriction spectrum imaging
COIS- Conflict of interest statements All authors declare no conflicts of interest.
EDAT- 2022/03/07 06:00
MHDA- 2022/05/25 06:00
PMCR- 2023/06/01
CRDT- 2022/03/06 20:28
PHST- 2021/04/30 00:00 [received]
PHST- 2021/12/27 00:00 [revised]
PHST- 2022/01/04 00:00 [accepted]
PHST- 2022/03/07 06:00 [pubmed]
PHST- 2022/05/25 06:00 [medline]
PHST- 2022/03/06 20:28 [entrez]
PHST- 2023/06/01 00:00 [pmc-release]
AID - S1054-139X(22)00002-7 [pii]
AID - 10.1016/j.jadohealth.2022.01.002 [doi]
PST - ppublish
SO  - J Adolesc Health. 2022 Jun;70(6):961-969. doi: 10.1016/j.jadohealth.2022.01.002. 
      Epub 2022 Mar 2.