PMID- 35248875
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20220606
IS  - 1873-622X (Electronic)
IS  - 0005-7967 (Linking)
VI  - 152
DP  - 2022 May
TI  - Mindfulness-Oriented Recovery Enhancement reduces opioid craving, pain, and 
      negative affect among chronic pain patients on long-term opioid therapy: An 
      analysis of within- and between-person state effects.
PG  - 104066
LID - S0005-7967(22)00037-7 [pii]
LID - 10.1016/j.brat.2022.104066 [doi]
AB  - Mindfulness-Oriented Recovery Enhancement (MORE) is an integrative treatment that 
      simultaneously addresses chronic pain and opioid misuse. MORE has been found to 
      produce sustained reductions in opioid craving, pain, and negative affect-key 
      risk mechanisms precipitating opioid misuse for patients on long-term opioid 
      therapy (LTOT). However, less is known about MORE's impact on state measures of 
      acute symptoms. We examined the impact of MORE versus a supportive psychotherapy 
      group (SG) among chronic pain patients on LTOT. Mixed models examined session and 
      momentary effects of MORE (n = 50) versus SG (n = 45) on state measures of 
      craving, pain, and negative affect. Decentering, curiosity, and time spent 
      engaging in daily mindfulness practice were examined as session effect 
      predictors. For session effects, statistically significant medium-to-large 
      effects of treatment group were observed in favor of MORE for craving, pain, and 
      negative affect. Higher levels of curiosity predicted improvements in craving, 
      whereas greater decentering and mindfulness practice were associated with 
      improvements in negative affect. For momentary effects, a significant group by 
      time interaction was observed for craving and pain. Findings suggest that MORE 
      provides immediate symptom relief on therapeutic targets in daily life among 
      chronic pain patients receiving LTOT.
CI  - Copyright (c) 2022. Published by Elsevier Ltd.
FAU - Parisi, Anna
AU  - Parisi A
AD  - Center on Mindfulness and Integrative Health Intervention Development, University 
      of Utah, United States; College of Social Work, University of Utah, United 
      States.
FAU - Hanley, Adam Wesley
AU  - Hanley AW
AD  - Center on Mindfulness and Integrative Health Intervention Development, University 
      of Utah, United States; College of Social Work, University of Utah, United 
      States.
FAU - Garland, Eric L
AU  - Garland EL
AD  - Center on Mindfulness and Integrative Health Intervention Development, University 
      of Utah, United States; College of Social Work, University of Utah, United 
      States. Electronic address: eric.garland@socwk.utah.edu.
LA  - eng
GR  - R01 DA042033/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220228
PL  - England
TA  - Behav Res Ther
JT  - Behaviour research and therapy
JID - 0372477
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/therapeutic use
MH  - *Chronic Pain/drug therapy
MH  - Craving
MH  - Humans
MH  - *Mindfulness
MH  - *Opioid-Related Disorders/complications/drug therapy
OTO - NOTNLM
OT  - Chronic pain
OT  - Craving
OT  - Mindfulness
OT  - Negative affect
OT  - Opioid
OT  - Pain
EDAT- 2022/03/07 06:00
MHDA- 2022/04/13 06:00
CRDT- 2022/03/06 20:32
PHST- 2021/11/17 00:00 [received]
PHST- 2022/02/16 00:00 [revised]
PHST- 2022/02/18 00:00 [accepted]
PHST- 2022/03/07 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2022/03/06 20:32 [entrez]
AID - S0005-7967(22)00037-7 [pii]
AID - 10.1016/j.brat.2022.104066 [doi]
PST - ppublish
SO  - Behav Res Ther. 2022 May;152:104066. doi: 10.1016/j.brat.2022.104066. Epub 2022 
      Feb 28.